Synthetic immune receptors and methods of use thereof

An immunoreceptor and sequence technology, applied in medical preparations containing active ingredients, fusion polypeptides, antibody medical components, etc., can solve the problems of apoptosis, immunological depletion, excessive cytokine release, etc.

Pending Publication Date: 2019-10-18
UNIV OF SOUTHERN CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some CARs display tonic antigen-independent signaling that leads to unrestrained cellular activation, ultimately leading to apoptosis, excessive cytokine release independent of cognate antigens, and immunological exhaustion

Method used

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  • Synthetic immune receptors and methods of use thereof
  • Synthetic immune receptors and methods of use thereof
  • Synthetic immune receptors and methods of use thereof

Examples

Experimental program
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Effect test

Embodiment

[0569] The activity of SIRs can be tested by several in vitro and in vivo assays described herein and below. A general scheme for generating, selecting and using suitable SIRs is provided below.

[0570] Identification of targets for SIR generation Suitable targets for designing SIRs are selected based on searches of libraries or gene expression databases. In general, suitable targets of SIRs show higher expression on disease-causing or disease-associated cells compared to normal healthy cells.

[0571] Generation of SIRs. Once the candidate target antigens of the SIRs are identified, the antigen-binding domains of the SIRs are designed based on the information available in the library. In general, the antigen binding domains of SIRs are typically based on antibodies, antibody fragments, scFV, or camelid vHH domains. The sequences of antibodies, camelid vHH domains, and variable chains of the heavy (vH) and light (vL) chains of various receptors and ligands can be obtained b...

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Abstract

The disclosure provides synthetic immune receptors (SIRs), nucleic acids encoding the SIRs, methods of making and using the SIRs, in, for example, adoptive cell therapy.

Description

[0001] Cross References to Related Applications [0002] This application claims priority under 35 U.S.C. §119 to U.S. Provisional Patent Application Serial No. 62 / 429,619, filed December 2, 2016, and U.S. Provisional Patent Application Serial No. 62 / 429,597, filed December 2, 2016, which provisional patents The disclosure of the application is incorporated herein by reference in its entirety. technical field [0003] The present invention relates to synthetic immune receptor (SIR) polypeptides, polynucleotides, expression constructs and the use of immune effector cells (eg T cells, NKT cells) and stem cells engineered to express synthetic immune receptors (SIR). The present disclosure also provides methods of using such polypeptides, polynucleotides, expression constructs, and recombinant cells to treat diseases and conditions, including but not limited to cancer, infectious diseases, allergic diseases, autoimmune diseases, degenerative diseases, or the aforementioned The co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/00A61K39/00A61K39/395C07K14/725C12N15/09C12N15/12
CPCA61K38/00C07K14/7051C07K2319/03A61K39/39558C07K16/00C07K16/2803C07K16/2851C07K16/2863C07K16/2866C07K16/2869C07K16/2878C07K16/2887C07K16/2896C07K16/30C07K16/32C07K2317/31C07K2317/622C07K2319/30C07K2319/32C07K2319/33C07K2319/50A61P17/00A61P19/00A61P19/02A61P21/04A61P25/28A61P29/00A61P31/12A61P31/14A61P31/16A61P31/18A61P31/20A61P31/22A61P35/00A61P35/02A61P3/10A61P37/02A61P37/06A61P43/00A61P5/00A61P7/00Y02A50/30A61K39/0011A61K2039/5156A61K2039/5158A61K2300/00A61K35/17A61K45/06C07K14/70517
Inventor P·M·乔德哈利
Owner UNIV OF SOUTHERN CALIFORNIA
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