Database for guiding individualized medicine taking of clinical tumor, constructing method and device thereof

Abstract

The invention provides a database for guiding individualized medicine taking of a clinical tumor, a constructing method, a searching method and a device thereof. The constructing method of the database comprises the steps of acquiring common data resources of information of a biomarker which is related to tumor chemotherapy, targeted and immunization medicine taking guidance; screening and classifying the common data resources, and obtaining key field and attribute of biomarker information; performing grade classification and dividing on clinical evidence information; establishing a deciphering database structure framework of the biomarker which is related with tumor chemotherapy, targeting and immunization; and recording the information which corresponds with the key field to the corresponding field position of the database structure framework for obtaining the database for guiding individualized medicine taking of the clinical tumor. According to the method, the multi-layer biomarkers which are detected through detecting technology such as high-flux sequencing and immunocytochemistry are comprehensively considered, thereby covering information at aspects of tumor chemotherapy, targeting and immunization medicine taking guidance, and making knowledge resource reserving for clinical medical guidance for individualized medicine taking of the tumor.

Description

technical field [0001] The present invention relates to the technical field of precision medicine, in particular to a database for guiding clinical tumor individualized medication and its construction method, retrieval method and device. Background technique [0002] With the completion of the Human Genome Project, the sequencing industry has developed rapidly in recent years, and the cost of sequencing has declined according to Moore's law. China is gradually entering the era of precision medicine. As genetic testing guides drug use is widely accepted by doctors, patients and their families, the market continues to expand, and more and more testing institutions are committed to providing individualized precision treatment testing and interpretation services for cancer patients. At present, in clinical practice, a large number of patients have begun to receive treatment programs tailored for them. [0003] The whole process of personalized precision treatment detection and ...

AI Technical Summary

Problems solved by technology

However, at present, most institutions on the market only provide targeted drug guidance for gene mutations, and the relevant databases for immune drug efficacy guidance are relatively scarce

[0005] At present, the information storage database (chemotherapy, targeting and immunization) for the guidance of precision medicine for tumors is relatively fragmented, and the database basically provides the relationship between gene variation and chemotherapy or / and targeted drugs, especially in the field of precision medicine for immunization. Few institutions collect multiple levels of biomarkers (multiple levels of biomarker labels detected based on high-throughput sequencing, immunohistochemistry and other detection technologies, etc.) to correlate and match immune drug information. In addition, in the introduction of related tumors, Various organizations have different standards for the classification of tumor pathology. There is no unified database record for the development of relevant chemotherapy, targeted and immune drugs in clinical tumor treatment, their mechanism of action, and toxic and side effects. The specific status of biomarkers and tumor Unclear elucidation of related relationships such as occurrence and development, etc., resulting in the need for relevant personnel to inquire about multiple information in the process of interpreting biomarkers related to individualized drug use for tumors

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