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Method of Obtaining Ion Beam Irradiation Scheme Based on Nanodosimetry

An ion beam and dosimetry technology, applied in the field of radiation applications, can solve the problems of inability to meet the design and verification of ion beam irradiation schemes, inability to apply, and inappropriate accuracy.

Active Publication Date: 2020-12-01
INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the limitations of the basic assumptions of the theory, when the radiation quality of the radiation field changes, some of the radiation effect parameters calculated by the model do not change accordingly, so that the model cannot be more accurate under conditions such as high dose rate and large dose irradiation. Irradiation scheme design and effective dose calculation results
In addition, Scholz et al. also proposed a local effect model (LEM). However, this model only uses an approximate ion beam track structure for related calculations, and the radiation damage interaction occurs at the micron scale. Therefore, the calculation results are in some The situation is quite different from the actual
In addition, since the method must be applied on the premise of knowing the radiation composition of the radiation field, it cannot be applied in the unknown radiation field
Another example is in the field of radiation protection, in order to distinguish rays with different radiation qualities, parameters such as radiation weight factors are often introduced, but these parameters are not suitable for situations requiring high accuracy
So far, the known ion beam radiation effect calculation methods cannot meet the requirements of more accurate ion beam irradiation scheme design and verification in a wide range of radiation quality

Method used

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  • Method of Obtaining Ion Beam Irradiation Scheme Based on Nanodosimetry
  • Method of Obtaining Ion Beam Irradiation Scheme Based on Nanodosimetry
  • Method of Obtaining Ion Beam Irradiation Scheme Based on Nanodosimetry

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Experimental program
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Embodiment 1

[0060] In this example, taking proton beams with an initial energy of 175 MeV and carbon ion beams with an initial energy of 330 MeV / u as examples, 10% of HSG cells within a range of 6 cm along the beam flow direction are expected to survive at a certain water equivalent depth The method of the present invention is used to obtain the corresponding irradiation scheme for the irradiation effect.

[0061] figure 1 is a schematic flow diagram of one embodiment of a method for obtaining an ion beam irradiation regimen based on nanodosimetry according to the present invention.

[0062] First, in step S11, the calibration conditions and radiation effects are selected according to the application scenario of this embodiment. In this embodiment, the calibration condition is LET (22.5keV / μm-483keV / μm); the radiation effect takes the cell survival rate of HSG at different water equivalent depths of the carbon ion beam as the quantitative index of the radiation effect (see Furusawa Y, F...

Embodiment 2

[0070] In this embodiment, it is verified that the calculation results of ion beam radiation effects obtained by the method of the present invention are consistent with the experimental data of irradiated cell biology.

[0071] In this embodiment, 10% cell survival of HSG cells is taken as the biological endpoint, and X-rays are used as reference radiation to calculate the RBE values ​​of carbon ion beams with different LETs. The calculation formula of RBE is as follows:

[0072] RBE=D X射线 / D 碳离子 (8)

[0073] where D X射线 and D 碳离子 are the absorbed dose of X-ray required to make the survival rate of HSG cells reach 10% and the absorbed dose of carbon ion beam with the corresponding LET value, respectively. D. X射线 =4.08Gy (refer to Furusawa Y, Fukutsu K, Aoki M, Itsukaichi H, Eguchi-Kasai K, Ohara H, Yatagai F, Kanai T, Ando K (2000) Inactivation of Aerobic and Hypoxic Cells from Three Different Cell Lines by Accelerated3He-, 12C-and 20Ne-Ion Beams. Radiation Research. 1...

Embodiment 3

[0077] In this embodiment, the verification method of the present invention is tested.

[0078] In this embodiment, the method (T K, Y F, K F (1997) Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ionradiotherapy. Radiation Research. 147 (1): 78) will be applied to Kanai et al. A carbon ion beam with an initial energy of 260 MeV / u can be used to verify the 10% expected survival of HSG cells within a range of 6 cm along the beam direction at a certain water equivalent depth.

[0079] Figure 4 is a schematic flow diagram of an embodiment of the verification method of the present invention. Such as Figure 4 Shown in, in step S21, select calibration condition; In step S22, under calibration condition, carry out the acquisition of nanodosimetry and radiation effect quantification simultaneously; In step S23, determine radiation effect parameter according to formula (6) and (7) .

[0080] In this embodiment, the calibration conditions are first selected...

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Abstract

The invention relates to a method for obtaining an ion beam irradiation scheme based on nano dosimetry. The method comprises the following steps of obtaining calibrated nano dosimetry quantities and quantifying an irradiation effect simultaneously under a calibration condition; determining irradiation effect parameters; calculating corresponding nano dosimetry quantities, applying the irradiationeffect parameters and optimizing the irradiation scheme. The invention further provides a method for verifying whether an existing ion beam irradiation scheme needs to be adjusted or not and an activebeam distributing device and a passive beam distributing device which implement the obtained ion beam irradiation scheme.

Description

technical field [0001] The invention belongs to the field of radiation applications, and in particular relates to a method for obtaining an ion beam irradiation scheme based on nanodosimetry and a method for verifying an existing irradiation scheme through the method. The present invention also relates to a passive beam distribution device and an active beam distribution device for implementing an ion beam irradiation regimen obtained by the method of obtaining an ion beam irradiation regimen based on nanodosimetry of the present invention. Background technique [0002] Ion beam (hereinafter sometimes referred to as beam) refers to a high-energy ion beam composed of charged particles (including protons, heavy ions, etc.). Ion beams are usually artificially prepared by accelerators that generate and form ion beams. In addition, various ion beam rays also exist in nature (especially outer space). Due to the special physical properties of ion beams, it has important applicati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01T1/02G01T7/00
CPCG01T1/02G01T7/00
Inventor 戴天缘李强陈卫强刘新国戴中颖贺鹏博马圆圆申国盛张晖
Owner INST OF MODERN PHYSICS CHINESE ACADEMY OF SCI