Sample desorption and ionization device, mass spectrometer and analysis method using the same

Abstract

The invention provides a sample desorption and ionization device, a mass spectrometer and an analysis method. The device has a first air pressure area and a second air pressure area lower than the first air pressure area; the device includes: a heating desorption device, located in the first air pressure area, used to carry a sample and perform heating, so that the analyte in the sample is desorbed from the sample under the action of heating and then enters the first air pressure area; a vacuum interface component connects the first air pressure area and the second air pressure area a pressure zone, used to make the analyte enter the second pressure zone from the first pressure zone driven by air flow; a soft ionization source, used to convert gas molecules in the second pressure zone into active gases Molecules, so that the analytes entering the second pressure zone can achieve soft ionization after interacting with the active gas molecules. The invention can significantly improve the introduction efficiency of ions after the analyte is ionized in the direct mass spectrometry analysis and the application range of the analyte.

Description

technical field [0001] The invention relates to the field of mass spectrometry, in particular to fast mass spectrometry, a method and an instrument for analyzing samples without chromatographic separation, ionization, and mass spectrometry. Background technique [0002] Chromatography-mass spectrometry technology has the characteristics of high selectivity and high sensitivity, thus becoming the gold standard in the field of chemical analysis. However, chromatography-mass spectrometry has disadvantages such as the need for complex sample preparation and the long time required for one analysis. For the purpose of simplifying sample preparation and removing chromatographic separation, direct mass spectrometry has developed rapidly since 2004. The core technology of this yyif is a type of ionization source that is ionized by the environment (Ambient Ionization), in which desorption electrospray ionization (DESI , "Science", volume 306, page 471, 2004) and direct real-time anal...

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Problems solved by technology

US8704170 discloses another two-step electric technology, which adopts the solution of normal pressure desorption and low pressure ionization, but this method fails to obtain the optimal ionization zone pressure to achieve soft ionization of weakly polar to polar substances

[0004] In the one-step ionization method and the two-step ionization method described above, both desorption and ionization occur under normal pressure. This scheme has the following disadvantages: 1. The analyte ions generated under normal pressure need to pass through the vacuum interface, and will be in the vacuum interface. Collision with the interface wall and loss, resulting in a decrease in sensitivity; 2. Failure to obtain appropriate conditions to enable the ionization process to achieve soft ionization of weakly polar analytes (such as alkanes, halogenated alkanes) and polar analytes

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