Sample desorption and ionization device, mass spectrometer employing same and analysis method

Abstract

The invention provides a sample desorption and ionization device, a mass spectrometer employing the same and an analysis method. The device is provided with a first air pressure region and a second air pressure region, wherein the second air pressure region is lower than the first air pressure region, the device comprises a heating and desorption device, a vacuum interface assembly and a soft ionization source, the heating and desorption device is arranged at the first air pressure region and is used for bearing a sample and heating the sample so that a to-be-analyzed substance in the sample is desorbed from the sample under a heating effect and then enters the first air pressure region, the vacuum interface assembly is connected with the first air pressure region and the second air pressure region and is used for allowing the to-be-analyzed substance to enter from the first air pressure region to the second air pressure region under driving of airflow, and the soft ionization source is used for converting gas molecule of the second air pressure region to active gas molecule so that the to-be-analyzed substance entering the second air pressure region acts with the active gas molecule and then soft ionization is achieved. By the device, the ion introduction efficiency after the analysis substance is ionized in direct mass spectrum analysis can be remarkably improved, and the application range of the analysis substance is expanded.

Description

technical field [0001] The invention relates to the field of mass spectrometry, in particular to fast mass spectrometry, a method and an instrument for analyzing, ionizing, and mass spectrometric analysis of samples without chromatographic separation. Background technique [0002] Chromatography-mass spectrometry technology has the characteristics of high selectivity and high sensitivity, thus becoming the gold standard in the field of chemical analysis. However, chromatography-mass spectrometry has disadvantages such as the need for complex sample preparation and the long time required for a single analysis. For the purpose of simplifying sample preparation and removing chromatographic separation, direct mass spectrometry has been developed rapidly since 2004. The core technology of this yyif is a type of ionization source that is ionized by the environment (Ambient Ionization), in which desorption electrospray ionization (DESI , "Science", volume 306, page 471, 2004) and ...

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Problems solved by technology

US8704170 discloses another two-step electric technology, which adopts the solution of normal pressure desorption and low pressure ionization, but this method fails to obtain the optimal ionization zone pressure to achieve soft ionization of weakly polar to polar substances

[0004] In the one-step ionization method and the two-step ionization method described above, both desorption and ionization occur under normal pressure. This scheme has the following disadvantages: 1. The analyte ions generated under normal pressure need to pass through the vacuum interface, and will be in the vacuum interface. Collision with the interface wall and loss, resulting in a decrease in sensitivity; 2. Failure to obtain appropriate conditions to enable the ionization process to achieve soft ionization of weakly polar analytes (such as alkanes, halogenated alkanes) and polar analytes

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