In-vitro neural network construction system based on robotization

A neural network and neuron technology, applied in the field of robot-based in vitro neural network construction system, can solve the problems of equipment cost, learning cost, high space requirements, and inability to simultaneously record multiple neurons at high throughput, achieving high flexibility and operability, saving equipment cost and difficulty of operation, high integration effect

Pending Publication Date: 2019-11-12
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Claims
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Problems solved by technology

However, the patch clamp technique has high requirements for equipment cost, learning cost and space. In addition, patch clamp recording cannot perform high-throughput simultaneous recording of multiple neurons.

Method used

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  • In-vitro neural network construction system based on robotization
  • In-vitro neural network construction system based on robotization

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Embodiment Construction

[0037] The technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Apparently, the described embodiments are some of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0038] Such as figure 1 and figure 2 As shown, the present invention provides a robot-based in vitro neural network construction system, including: a biological culture dish 1 , a laser subsystem 2 and a displacement control platform 3 .

[0039]Wherein the biological petri dish 1 is provided with neuron tissue to be constructed; the laser subsystem 2 includes a laser source 21, a laser conduction device 22 and a focusing objective lens 23, and the laser source 21 and the laser conduction device 22 are conne...

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Abstract

The invention discloses an in-vitro neural network construction system based on robotization. Neuron tissues to be constructed are arranged in a biological culture dish. A laser subsystem comprises alaser source, a laser conduction device and a focusing objective lens. The laser source is connected with the laser conduction device through an energy supply cable and used for conducting laser energy, the focusing objective lens is connected with the laser conduction device through a laser optical fiber, the focusing objective lens is arranged above the biological culture dish, and the focusingobjective lens is used for focusing conducted laser. The focusing objective lens is fixed on the displacement control platform, the biological culture dish is arranged below the focusing objective lens by controlling the displacement control platform to move, and laser ablation or optical stimulation is carried out on target point cells or tissues in the biological culture dish. According to the method, specific activation can be carried out on a single neuron, meanwhile, responses of other neurons in the neural network can be recorded, integration is easy, the integration cost is low, and very high flexibility and operability are achieved.

Description

technical field [0001] The invention belongs to the technical field of bioengineering and mechanical automation control and brain-inspired technology research methods, and specifically relates to a robot-based in vitro neural network construction system, which can be used to explore the neuron network structure connection and information transmission characteristics under bionic conditions. Provide algorithm structure and transfer function model for brain-inspired simulation calculations, and explore new robot control theory research based on brain-inspired control. Background technique [0002] In recent years, a variety of new technologies have been applied in the field of neuroscience research, especially the application of laser technology in the fields of fluorescent labeling of nerve cells, optogenetic neuron activation, fluorescent recording of neuronal calcium activity, and laser bleaching. The development of neuroscience provides an effective means to accelerate the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06N3/067
CPCG06N3/0675
Inventor 李光辉奚鹏程蒋理想吕晓东王延超何际平
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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