A kind of preparation technology of compound salvia miltiorrhiza preparation and compound salvia miltiorrhiza preparation

A compound salvia miltiorrhiza and preparation process technology, applied in the field of medicine, can solve the problems of large differences in effective components and yields, low content of active components, large content differences, etc., and achieve the benefits of quality control, ensuring consistency and improving yield. rate effect

Active Publication Date: 2021-07-23
金鸿药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since the active ingredients in Salvia miltiorrhiza, such as tanshinone Ⅱ A, salvianolic acid B, etc., have large differences in content in different medicinal materials, in the preparation process of compound Danshen preparations, it is easy to only control the total amount of raw materials in different batches of preparations. The active ingredients and yields between different batches are quite different
The existing preparation process of compound salvia miltiorrhiza preparations has the problems of low content of active ingredients, low yield, and large differences between batches

Method used

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  • A kind of preparation technology of compound salvia miltiorrhiza preparation and compound salvia miltiorrhiza preparation
  • A kind of preparation technology of compound salvia miltiorrhiza preparation and compound salvia miltiorrhiza preparation
  • A kind of preparation technology of compound salvia miltiorrhiza preparation and compound salvia miltiorrhiza preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Take the preparation of 100,000 bags of compound danshen granules as an example, each bag of compound danshen granules is 1 g.

[0037] (1) Salvia miltiorrhiza extract powder extraction

[0038]① Pre-treatment of Danshen: Classify and select Danshen according to the diameter of the upper part of the main root of the salvia miltiorrhiza.

[0039] Detect the content of active ingredients in Class I and Class II Danshen medicinal materials; refer to the detection method on pages 76-77 of the Chinese Pharmacopoeia 2015 Edition to detect tanshinone and tanshinone II A and salvianolic acid B content.

[0040] The result is as follows:

[0041] Classification moisture Tanshinones Tanshinone Ⅱ A

Salvianolic acid B one type 11.4％ 0.59％ 0.35％ 5.3％ Class II 12.1％ 0.48％ 0.26％ 6.5％

[0042] The total feeding amount is 135kg, wherein 90kg of the first-class salvia miltiorrhiza medicinal material and 45kg of the second-class salvia miltior...

Embodiment 2

[0073] Take the preparation of 100,000 bags of compound danshen granules as an example, each bag of compound danshen granules is 1 g.

[0074] (1) Salvia miltiorrhiza extract powder extraction

[0075] ① Pre-treatment of Danshen: Classify and select Danshen according to the diameter of the upper part of the main root of the salvia miltiorrhiza.

[0076] Detect the content of active ingredients in Class I and Class II Danshen medicinal materials; refer to the detection method on pages 76-77 of the Chinese Pharmacopoeia 2015 Edition to detect tanshinone and tanshinone II A and salvianolic acid B content.

[0077] The result is as follows:

[0078] Classification moisture Tanshinones Tanshinone Ⅱ A

Salvianolic acid B one type 11.9％ 0.70％ 0.36％ 6.0％ Class II 12.1％ 0.40％ 0.20％ 6.2％

[0079] The total feeding amount is 135kg, wherein 90kg of the first-class salvia miltiorrhiza medicinal material and 45kg of the second-class salvia miltio...

Embodiment 3

[0110] Take the preparation of 100,000 bags of compound danshen granules as an example, each bag of compound danshen granules is 1 g.

[0111] (1) Salvia miltiorrhiza extract powder extraction

[0112] ① Pre-treatment of Danshen: Classify and select Danshen according to the diameter of the upper part of the main root of the salvia miltiorrhiza.

[0113] Detect the content of active ingredients in Class I and Class II Danshen medicinal materials; refer to the detection method on pages 76-77 of the Chinese Pharmacopoeia 2015 Edition to detect tanshinone and tanshinone II A and salvianolic acid B content.

[0114] The result is as follows:

[0115] Classification moisture Tanshinones Tanshinone Ⅱ A

Salvianolic acid B one type 12.3％ 0.57％ 0.32％ 5.8％ Class II 12.3％ 0.43％ 0.23％ 5.7％

[0116] The total feeding amount is 135kg, wherein 90kg of the first-class salvia miltiorrhiza medicinal material and 45kg of the second-class salvia miltio...

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Abstract

The invention discloses a preparation process of a compound salvia miltiorrhiza preparation and the compound salvia miltiorrhiza preparation. The preparation process includes performing pretreatment on the salvia miltiorrhiza. , get Danshen slices. The diameter of the upper part of the main root of Danshen medicinal materials is less than 0.5 cm, and the diameter of the upper part of the main root is greater than or equal to 0.5 cm. A The content of salvianolic acid B and the first-class and second-class salvia miltiorrhiza medicinal materials are configured in proportion. The preparation process of the present invention classifies and selects the medicinal materials of Salvia miltiorrhiza, and carries out reasonable proportioning, and also improves the preparation process, which can increase the content and yield of active ingredients, reduce the difference between batches at the same time, and improve the production efficiency. efficiency.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a preparation process of a compound salvia miltiorrhiza preparation and the compound salvia miltiorrhiza preparation. Background technique [0002] Cardiovascular and cerebrovascular diseases are the first disease that causes human death. With the improvement of social living standards and the aging of the population, the research on drugs for cardiovascular and cerebrovascular diseases has become a hot spot in drug development. Coronary atherosclerotic heart disease, referred to as coronary heart disease, is caused by the deposition of some blood lipids such as cholesterol and triglycerides that cannot penetrate into the arterial wall to form "atherosclerotic plaque" on the intima of the artery. The deposition of calcium in the fluid makes the original elastic arteries harden. As the range of atherosclerotic plaque on the arterial intima increases, the vessel cavity becomes ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61P9/00A61P9/10A61K31/045
CPCA61K31/045A61K36/258A61K36/537A61K2236/13A61K2236/15A61K2236/333A61K2236/39A61K2236/51A61P9/00A61P9/10A61K2300/00
Inventor 上官清李莎洪艳
Owner 金鸿药业股份有限公司
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