45results about How to "Small batch variance" patented technology

The invention discloses a method for preparing super-microporous flexible carbon cloth.Carbon cloth serves as a raw material and is calcined at high temperature in activators, and the super-microporous flexible carbon cloth is obtained.The calcination temperature is 400-1,500 DEG C, and calcination time is 1-24 h.The activators are nitrogen and oxygen, and the volume ratio of nitrogen to oxygen is 100:(0.5-2).The invention further discloses the super-microporous flexible carbon cloth and application of the super-microporous flexible carbon cloth to a flexible all-solid-state capacitor and water electrolysis hydrogen making.According to the technical scheme, a calcination method is utilized for the first time, no reagent is needed, and the synthesis method is simple, environmentally friendly and beneficial for large-scale production; the prepared super-microporous flexible carbon cloth has a large specific area, high-proportion micropores, good electric conductivity and good flexibility and super hydrophilicity.

A preparing method of N,S-codoped graphene / MoSe2 / CoFe-LDH aerogel is provided. The method is characterized by including S1) separately preparing a graphene oxide sheet dispersion, a MoSe2 nanosheet dispersion and a layered CoFe-LDH nanosheet dispersion; S2) mixing the graphene oxide sheet dispersion and the MoSe2 nanosheet dispersion, adding a reductant and a crosslinking agent, fully mixing the mixture, reacting the mixture to obtain N,S-codoped graphene / MoSe2 hydrogel, freeze-drying the hydrogel to obtain N,S-codoped graphene / MoSe2 aerogel; and S3) soaking the N,S-codoped graphene / MoSe2 aerogel in the layered CoFe-LDH nanosheet dispersion to obtain N,S-codoped graphene / MoSe2 / CoFe-LDH hydrogel, and freeze-drying the hydrogel to obtain the N,S-codoped graphene / MoSe2 / CoFe-LDH aerogel. The prepared ternary N,S-codoped graphene / MoSe2 / CoFe-LDH aerogel has more excellent hydrogen evolution and oxygen evolution properties under alkaline conditions.

The invention discloses a preparation method and application of a functional carbon nanotube loaded Pd catalyst. The preparation method comprises the following steps: carrying out in-situ introductionof carbon quantum dots through low temperature pyrolysis of citric acid and carrying out surface modification on carbon nanotubes; meanwhile, introducing nitrogen elements for co-modification; in addition, preparing a carbon-based catalyst with a metallic state Pd content as high as 76 percent by adopting simple processes such as equal-volume impregnation and hydrogen reduction. The catalyst hasobvious catalytic oxidation activity on benzyl alcohol (and derivatives thereof) and fatty alcohols; besides, the performance can be optimized by regulating synthesis conditions, so that the catalyticoxidation conversion rate of the benzyl alcohol can reach 92 percent.

The invention discloses a preparation method of a phosphorus-doped cobalt telluride nano material, which comprises the following steps: preparing cobalt hydroxide by using cobalt nitrate and urea as raw materials through a hydrothermal method, calcining to obtain Co3O4 nanosheets, grinding and mixing the Co3O4 nanosheets and tellurium powder, and calcining in an Ar atmosphere to obtain CoTe2 nanosheets; and finally, grinding and mixing the CoTe2 nanosheets and sodium hypophosphite, and calcining in Ar gas to obtain the phosphorus-doped CoTe2 nanoparticle material. According to the invention, phosphorus is doped, so electron cloud density of surrounding CoTe2 is changed, and favorable synergistic effect is generated to improve HER activity; the prepared P-CoTe2 nano-particle is of a porousstructure, is high in specific surface area and high in electrical conductivity, has stable and efficient catalytic hydrogen evolution performance in acidic and alkaline environments, and can be usedas an electrocatalyst for hydrogen evolution reaction by hydrolysis.

The invention relates to a preparation method for flucloxacillin sodium. The method comprises the following steps of: (1) weighing 6-aminopenicillanic acid, 3-(2-chloro-6-fluorophenyl)-5-methyl isoxazole-4-phosgene and sodium iso-octoate; (2) adding water into 6-aminopenicillanic acid, cooling in an ice bath, and adding acetone to obtain a solution A; (3) preparing 3-(2-chloro-6-fluorophenyl)-5-methyl isoxazole-4-carbonyl chloride and an organic solvent into a solution B; (4) adding the solution B into the solution A, and performing an acylation reaction; (5) after reacting, acidifying, and adding an organic solvent for extracting; (6) slowly adding a part of organic solution of sodium iso-octoate into the an extracting solution obtained in the step (5), performing a salt-forming reaction, and growing a crystal after the crystal is precipitated out; and (7) after growing the crystal, continually adding the residual sodium iso-octoate solution, preserving heat, stirring, leaching, soaking, washing and drying in vacuum. The method has the advantages of short process route, high process operability and capability of effectively increasing product quality and yield.

The invention belongs to the field of the molecular biology, and particularly relates to a magnetic microsphere with a molecular tag sequence, and a preparation method for the magnetic microsphere. Amagnetic bead is taken as a molecular tag base, and a chemical bond and enzyme linking method is used for linking three-segment oligo to the magnetic bed in sequence so as to synthesize the magnetic microsphere with a unique oligo sequence. The magnetic microsphere prepared by the preparation method disclosed by the invention has high stability and accuracy. Meanwhile, the preparation technology of the magnetic microsphere is simple, time consumption is small, raw material sources are convenient, the cost is low, and the unicellular sequencing cost is greatly lowered. The oligo adopted by themagnetic microsphere is a known sequence, the three-segment oligo can be combined to form millions of molecular tags, batch differences are small, the stability and the accuracy of a unicellular sequencing result are obviously improved, and the magnetic microsphere can be widely applied to medical research, bioresearch and the like.

The invention discloses a multi-layer tablet containing dabigatran etexilate mesylate. The multi-layer tablet comprises a tablet core and a coating film; the tablet core comprises at least one drug-containing layer containing dabigatran etexilate mesylate and at least one organic acid layer. The multi-layer tablet is capable of increasing the solubility in vivo and the absorption rate in vivo, and also capable of effectively controlling the release time in vivo, and further is low in batch difference, and therefore, the safety of drug use is improved. Meanwhile, the multi-layer tablet is used for solving the problem that other substances are generated due to crystal transformation in the production and storage processes, and the production quality is improved and the storage time is prolonged. In addition, the multi-layer tablet further has the characteristics of convenience for swallowing, simple production process and high reproducibility.

The invention belongs to the field of metal materials and particularly relates to an Al-P intermediate alloy which is used to refine primary crystal silicon in the Al-Si alloy and Mg2Si in the Mg-Si alloy, and a preparation method thereof. The Al-P intermediate alloy contains two elements, namely Al and P. The Al-P intermediate alloy is characterized in that the alloy comprises the following components by weight percent: 92.5-98.5% of Al, 1.5-7.5% of P and less than 0.8% of impurities. The preparation method of the Al-P intermediate alloy comprises the following steps of: mixing aluminum powder and black phosphorus powder evenly, drying, briquetting with a press machine, placing the obtained blocks in an electric furnace with the inert atmosphere or other heating devices, heating to 600-750 DEG C, keeping the temperature for 45-120 minutes, stopping heating, and cooling along with the furnace to obtain the blocky Al-P intermediate alloy or extruding the sintered blocks into wires. The Al-P intermediate alloy has a good refinement effect on the Al-Si alloy and the Mg-Si alloy.

The invention provides a making technology of low-salt flavored fermented bean curd, and relates to the technical field of food processing. The making technology comprises the following steps of pretreating raw materials; performing grinding to obtain pulp, and cooking the pulp; making semi-finished products; performing inoculation with bacteria and performing fermentation; rubbing hair and performing pickling; and performing later-stage fermentation. Through the adoption of the making technology, the amount of pickling salt is reduced; and vacuum pickling is adopted, so that on one hand, permeation of the salt can be well promoted, and on the other hand, the situations that bacteria are increased and the low-salt flavored fermented bean curd is putrid and deteriorated due to reduction ofsalt content can be avoided. Mucor and rhizopus oligosporus are mixed to be made into yeast, and two kinds of strain systems are relatively stable. In the later-stage fermentation process, an antioxidant and a flavoring agent are added. The made fermented bean curd is low in salt content, unique in flavor and fragrant and rich in taste, and has health-care effects; and besides, formation of whitespots is reduced, and taste of the fermented bean curd is improved.

The invention provides a preparation method of low-salt fermented bean curd, and belongs to the technical field of food processing. The preparation method comprises following steps: raw material pretreatment, pulp grinding, pulp cooking, soy cheese pehtze preparation, inoculation and fermentation, pressing of hypha and salting, and later fermentation. The preparation method is capable of reducingsalt using amount in the step of salting, and vacuum salting is adopted, so that on one hand, penetration of salt is promoted, and on the other hand, increasing of bacteria and corruption deterioration caused by low salt content are avoided. According to the preparation method, mucor and rhizopus oligosporus are mixed for starter propagation, and the two mould systems are relatively stable; an anti-oxidant is added in later fermentation. The obtained low-salt fermented bean curd is low in salt content, the whole taste of the low-salt fermented bean curd is not influenced, formation of white spots is reduced, and fermented bean curd taste is improved.

The invention provides a method for visually representing an electrolyte seepage effect. The method comprises the following steps of providing an electrolyte and a coloring agent; mixing the electrolyte and the coloring agent to form a coloring electrolyte, wherein the volume ratio of the electrolyte to the coloring agent is (60-100) to 1; and filling the electrolyte into a battery, then disassembling the battery, and observing the color distribution and the reflective degree of a separator and a negative electrode plate so as to determine the electrolyte seepage effect.

The invention discloses a reversible temperature change erasable neutral ink composition and its manufacturing method. The composition comprises the following components by weight: (a) 30-50 parts of a reversible temperature change pigment; (b) 2-5 parts of a shear thinning viscosity conditioning agent; (c) 0-5 parts of a viscosity stabilizer; (d) 5-20 parts of a moisturizing wetting agent; (e) 0.05-0.5 part of an antiseptic antimildew agent; and (f) 14.5-72.95 parts of deionized water. The total weight of the components (a)-(f) accounts for 95-100% of the total weight of the composition. The neutral ink provided in the invention has excellent writing performance, instantaneous erasability, long time erasability as well as excellent rewriting performance.

The invention relates to a method for producing oxytetracycline calcium premix by streptomyces rimosus fermentation, and belongs to the technical field of veterinary drug. In the method, the technicalconditions of a seed preparation process are optimized, so that the prepared seed has the characteristics of stable metabolism, small batch difference, high hypha concentration, small protein content, less heat-source matters and the like. Meanwhile, according to the method, culture medium ingredients are optimized, the culture medium is used for culturing the seeds so as to be favorable for thesynthesis of an oxytetracycline special structure and the improvement of the yield of the oxytetracycline calcium premix and also be favorable for subsequently separating and purifying the oxytetracycline calcium premix. A high-pressure diaphragm sheet frame machine is adopted to filter, and a flash evaporation dryer is used for drying. Compared with the traditional production method for the oxytetracycline calcium premix, the method disclosed by the invention is characterized in that a fermentation unit and yield can be effectively improved, production cost is lowered, meanwhile, the use of chemical organic solvent is avoided, pollution caused by the organic solvent for the oxytetracycline is avoided, and harm on animals is avoided.

The invention provides a seed emulsion and a preparation method thereof. The seed emulsion is prepared in an emulsion polymerization mode by taking the following raw materials in parts by weight: 0-100 weight parts of (methyl) acrylic ester, 0-100 weight parts of vinyl benzene, 10-20 weight parts of an emulsifying agent, 2-10 weight parts of a buffering agent, 100-200 weight parts of deionized water and 0.5-3 weight parts of an initiator. The seed emulsion provided by the invention is small in emulsion particle diameter and can be applied to the products with smaller particle diameter; the change of the scope of the particle diameter of the designable emulsion is large; the additive amount is less; the influence on the final products is less; the batch stability of the compounded emulsion is high; the particle diameter of the final products can be freely designed; the particle diameter distribution is narrow; the system viscosity is low; the control on the reaction process is benefited; the system gel dosage is less.

The invention relates to a preparation method of hydrogen tungsten bronze / ultra-microporous flexible carbon cloth, comprising the following steps: 1) impregnating an ultra-microporous flexible carboncloth into a 0.1-10 M ammonium metatungstate solution, performing ultrasonical treatment and then drying to obtain an ultra-microporous flexible carbon cloth loaded with ammonium metatungstate; 2) calcining the ultra-microporous flexible carbon cloth loaded with ammonium metatungstate obtained in step 1) to obtain a hydrogen tungsten bronze / ultra-microporous flexible carbon cloth having surface and internal oxygen vacancies. The invention also relates to products and applications prepared by the preparation method. The method makes the hydrogen tungsten bronze form a uniform nanowire morphology on the ultra-microporous flexible carbon cloth, and has high surface and internal oxygen vacancies, and the surface oxygen vacancy is significantly higher than the internal oxygen vacancy.

The invention discloses a solid dispersion, a preparation, a preparation method and application thereof. The solid dispersion comprises a carrier and an active component, wherein the active component is a compound shown as a formula (I) and / or a pharmaceutically acceptable salt thereof; the carrier is a homopolymer and a copolymer of N-vinyl lactam and / or a pH dependent cellulose derivative. The preparation comprises the solid dispersion, a filling agent and a disintegrating agent. The solid dispersion disclosed by the invention has good dissolution rate, the solubility of effective components is remarkably improved, the bioavailability of the Bcl-2 inhibitor can be effectively improved, the solid dispersion has good dissolution rate and stability, and the medication safety can be improved.

The invention provides a nano-platform for overcoming the vector epitope inhibition effect of a vaccine. Albumins used as a raw material are reduced, thermopolymerizied, oxidized and concentrated, andthen are externally linked with an antigen epitope to obtain a target vaccine vector, wherein the reduction is carried out to reduce disulfide bonds in the albumins into sulfhydryl groups; the thermopolymerization is carried out to obtain nano-particles formed in an albumin self-assembling manner; and the oxidation is carried out to oxidize the sulfhydryl groups into the disulfide bonds. The nano-platform is a nano-vaccine vector having the advantages of completeness in inhibiting the production of vector protein antibodies, green and simple synthesis process, no involving of toxic chemicalsor complicated processes, low cost, small batch difference and great clinical transformation prospect.

The invention discloses a method for preparing secondary cannabidiol, which at least comprises the following steps: a) pretreating a raw material containing industrial hemp to obtain a pretreated material; b) performing alcohol extraction on the pretreated material, concentrating an extracting solution I to obtain a concentrated solution, adding water for decarboxylation, and concentrating II to obtain a dry extract; c) mixing the dry extract and an adsorbent I to form a solid dispersion system, and performing solid-phase extraction to obtain a secondary cannabidiol primary product solution; d) subjecting the crude cannabidiol solution to concentration III, decoloration and crystallization so as to obtain the secondary cannabidiol. The preparation method is simple in process, high in product transfer rate, time-saving, labor-saving, large in treatment capacity, high in product purity and suitable for industrial large-scale production.

The invention provides a manufacturing method of a glass fiber-reinforced plastic integrated septic tank storage pot. The manufacturing method is characterized in that a vacuum membrane (7), and the inner walls of a middle cylinder mold (1) and an end socket mold (2) both for the septic tank storage pot are combined to form an airtight cavity (9) isolated from outside air, the airtight cavity (9) is provided with a plurality of resin injection pipelines (91) located at different horizontal heights and a plurality of vacuum supply pipelines (92) located at the highest position, the airtight cavity (9) is kept in vacuum through air exhaust, resin is absorbed into the airtight cavity (9) through the resin injection pipelines (91), and then a glass fiber-reinforced plastic cylinder (10) and an end socket (20) are formed after solidification. After the auxiliary structure of the storage pot is fabricated completely, the cylinder (10) and the end socket (20) are assembled into the integrated glass fiber-reinforced plastic septic tank storage pot. The manufacturing method provided by the invention is capable of producing the glass fiber-reinforced plastic storage pot which is higher in compactness, higher in strength and more stable in quality, and the process of the manufacturing method is clean and has environment-friendly effect. Provided that the cylinder mold of a corrugated concave-convex structure (11) is adopted, a support in the cylinder can be further omitted, and consequently, the compressive strength and bending strength of the cylinder can be improved.

The invention discloses an aptamer of methotrexate, an aptamer derivative and application of the aptamer and the aptamer derivative. A nucleotide sequence of the aptamer comprises DNA molecules as shown in sequences 1-5. The aptamer can be a derivative obtained from various similar sequences with high homology or derivatives provided by the invention. A method for detecting the methotrexate is established by utilizing the specific binding effect of the aptamer HMX38 and the methotrexate for the first time. The aptamer and the derivative thereof can be used for preparing methotrexate detection probes and drug carriers or used for drug design and development, drug separation and purification and the like. The aptamer and the derivative thereof have the advantages of being capable of being combined with methotrexate with high specificity and high affinity, free of immunogenicity, capable of being chemically synthesized, good in biocompatibility, small in molecular weight, stable, easy to store and the like.

The invention discloses a multi-layer tablet containing dabigatran etexilate mesylate. The multi-layer tablet comprises a tablet core and a coating film; the tablet core comprises at least one drug-containing layer containing dabigatran etexilate mesylate and at least one organic acid layer. The multi-layer tablet is capable of increasing the solubility in vivo and the absorption rate in vivo, and also capable of effectively controlling the release time in vivo, and further is low in batch difference, and therefore, the safety of drug use is improved. Meanwhile, the multi-layer tablet is used for solving the problem that other substances are generated due to crystal transformation in the production and storage processes, and the production quality is improved and the storage time is prolonged. In addition, the multi-layer tablet further has the characteristics of convenience for swallowing, simple production process and high reproducibility.

The invention discloses a preparation method of polyamide 6, at least caprolactam is used as a raw material to prepare polyamide 6 through a continuous process, and a catalyst is added in any link of material mixing, amide exchange reaction in a polymerization stage, extraction and drying in the preparation process; and the polymerization stage comprises a pre-polymerization reaction and at least one section of amide exchange reaction which are carried out in sequence, and melt generated by any section of amide exchange reaction can be subjected to pelletizing, extraction and drying to prepare a polyamide 6 slice finished product. The polyamide 6 prepared by the method has the characteristics of high production efficiency, high process operability, low energy consumption and the like. The prepared polyamide 6 is stable in quality, uniform in molecular weight distribution and excellent in performance.

The invention discloses a continuous production method of BHK21 cells by carrying out suspension culture, preservation and resuscitation in a bioreactor as well as application of the BHK21 cells, andbelongs to the field of cell preservation in biological pharmacy. According to the continuous production method of the BHK21 cells by carrying out suspension culture, preservation and resuscitation inthe bioreactor provided by the invention, BHK21 cells in the bioreactor can be preserved for up to 15 days or above by adjusting low-temperature preservation conditions in the bioreactor and / or repeating low-temperature preservation and resuscitation; and moreover, the BHK21 cells meeting cell density and cell vitality requirements for production can be continuously obtained. In addition, the obtained BHK21 cells are small in batch difference, so that product quality stability can be ensured so as to have production efficiency improved.

The invention provides a 3D-structured composite hydrogen-evolving electrode and a preparation method thereof. The preparation method comprises dissolving cobalt chloride, sodium tungstate and graphene oxide dispersion in deionized water, ultrasonically dispersing, pouring into a hydrothermal kettle, adding foam nickel which grows Co3O4, carrying out hydrothermal reaction to obtain foam nickel loaded with RGO / CoWO4 / Co3O4; removing the foam nickel loaded with RGO / CoWO4 / Co3O4 from the hydrothermal kettle, washing, and drying to obtain the 3D-structured composite hydrogen-evolving electrode. The3D-structured composite hydrogen-evolving electrode has large specific surface area, high conductivity, good electrocatalytic hydrogen-evolving effect, good cycle performance, good environmental friendliness and other advantages.

The invention discloses a preparation method of copolyamide, wherein the preparation method is characterized in that at least caprolactam and nylon diamine diacid salt are used as raw materials to prepare the copolyamide through a continuous process, and a catalyst is added in any link of material mixing, amide exchange reaction in a polymerization stage, extraction and drying in the preparation process of the copolyamide. The copolyamide prepared by the method has the characteristics of high production efficiency, high process operability, low energy consumption and the like. The prepared copolyamide is stable in quality and excellent in performance.