Preparation method for external-use antibacterial gel used for female vagina

A gel and vaginal technology, which is applied in the field of gynecological antibacterial gel preparation, can solve the problems of easy loss of antibacterial components and poor biocompatibility of hydrogel dressings, and achieve the promotion of silver ion reduction reaction and no immune rejection of organisms , the effect of simple operation

Pending Publication Date: 2019-12-03
江苏领驰供应链管理有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to solve the technical defects of the prior art that the antibacterial components in the antibacterial gel are easy to lose and the biocompatibility of the hydrogel dressing is poor, the present invention provides a preparation method of an antibacterial gel for female vaginal external use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A preparation method of antibacterial gel for female vaginal external use, comprising the following steps:

[0020] (1) Add the multi-walled carbon nanotubes to the sulfuric acid solution, and after ultrasonic treatment for 40 minutes, remove two-thirds of the solution by rotary evaporation to obtain a modified multi-walled carbon nanotube suspension, wherein the molar concentration of the sulfuric acid solution is 0.1mol / L, every gram of multi-walled carbon nanotubes was added to 3ml of sulfuric acid solution;

[0021] (2) In parts by weight, 12 parts of N,N-dimethylaminoethyl acrylate, 17 parts of diethylene glycol dimethacrylate, 38 parts of hydroxyethyl methacrylate, 3 parts of modified multi-walled carbon nano Tube suspension, 0.1 part of dicumyl peroxide, and 0.05 part of tetramethylethylenediamine are mixed evenly to prepare a precursor solution, and after adding an initiator to the precursor solution, after mixing evenly, add it to the mold and let it stand The...

Embodiment 2

[0024] A preparation method of antibacterial gel for female vaginal external use, comprising the following steps:

[0025] (1) Add the multi-walled carbon nanotubes to the sulfuric acid solution, and after ultrasonic treatment for 45 minutes, remove two-thirds of the solution by rotary evaporation to obtain a suspension of modified multi-walled carbon nanotubes, wherein the molar concentration of the sulfuric acid solution is 0.1mol / L, every gram of multi-walled carbon nanotubes was added to 4ml of sulfuric acid solution;

[0026] (2) In parts by weight, 16 parts of N,N-dimethylaminoethyl acrylate, 18 parts of diethylene glycol dimethacrylate, 40 parts of hydroxyethyl methacrylate, 5 parts of modified multi-walled carbon nano Tube suspension, 0.2 parts of benzoyl peroxide, and 0.07 parts of tetramethylethylenediamine are mixed evenly to prepare a precursor solution. After adding an initiator to the precursor solution, mix it evenly, add it to the mold, and let it stand for tre...

Embodiment 3

[0029] A preparation method of antibacterial gel for female vaginal external use, comprising the following steps:

[0030] (1) Add the multi-walled carbon nanotubes to the sulfuric acid solution, and after ultrasonic treatment for 50 minutes, remove two-thirds of the solution by rotary evaporation to obtain a modified multi-walled carbon nanotube suspension, wherein the molar concentration of the sulfuric acid solution is 0.1mol / L, every gram of multi-walled carbon nanotubes was added to 5ml of sulfuric acid solution;

[0031] (2) In parts by weight, 18 parts of N,N-dimethylaminoethyl acrylate, 20 parts of diethylene glycol dimethacrylate, 44 parts of hydroxyethyl methacrylate, 6 parts of modified multi-walled carbon nano Tube suspension, 0.3 parts of di-tert-butyl peroxide, and 0.08 parts of tetramethylethylenediamine were mixed uniformly to prepare a precursor solution. After adding an initiator to the precursor solution, after mixing uniformly, added to the mold, and static...

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Abstract

The invention discloses a preparation method for an external-use antibacterial gel used for a female vagina. The preparation method comprises the following steps of: (1) adding a multi-walled carbon nanotube into a sulfuric acid solution to prepare a modified multi-walled carbon nanotube suspension; (2) after N,N-dimethylaminoethyl acrylate, dimethylacrylic acid diethylene glycol ester, hydroxyethyl methylacrylate, the modified multi-walled carbon nanotube suspension, a cross-linking agent and a coagulant are evenly mixed, preparing a precursor solution, preparing a hydrogel after an initiatoris added into the precursor solution, and carrying out freeze drying processing on the hydrogel to obtain a hydrogel dressing; and (3) adding silver nitrate and uridine 5-monophosphate into water, evenly mixing and stirring to obtain an anti-bacterial solution, adding the hydrogel dressing into the anti-bacterial solution, carrying out dipping processing, taking out the hydrogel dressing, cleaning a surface by deionized water, then, adding the hydrogel dressing into a reduction liquid, and carrying out ultrasonic processing to obtain the antibacterial gel. The antibacterial gel prepared by the preparation method disclosed by the invention has the advantages of excellent stability performance and long storage time and also has excellent biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of preparation of antibacterial gel for gynecological use, and in particular relates to a preparation method of antibacterial gel for female vaginal external use. Background technique [0002] Bacterial vaginosis is a common gynecological disease. After the onset, symptoms such as frequent urination, dysuria, increased vaginal discharge, and genital itching can be manifested. Due to the physiological structure of the vagina and the particularity of the local microenvironment, there are problems such as easy drug loss after administration, short residence time, and difficulty in administration after vaginal administration, which has attracted more and more researchers' attention in recent years. The gel as a semi-solid preparation has good moisture retention, is easy to spread, and can be firmly attached to the inner wall of the vagina. Therefore, the drug delivery system can prevent the rapid loss of drugs, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/04A61K47/32A61K33/38A61P31/04A61P15/02
CPCA61K9/0034A61K9/06A61K47/02A61K47/32A61K33/38A61P31/04A61P15/02
Inventor 邓伟辉
Owner 江苏领驰供应链管理有限公司
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