Polyketone compounds with trans-naphthane ring and preparation method and application thereof
A compound and decalin ring technology, applied in the field of microbial pesticides, can solve the problems of environmental pollution, endangering the safety of agricultural products and human health, excessive pesticide residues, etc., and achieve the effect of good environmental compatibility and difficult drug resistance.
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Embodiment 1
[0029] Embodiment 1: The preparation method of compound 1 and compound 2 represented by formula (1).
[0030] 1) Strain fermentation culture
[0031] Cut out the strains grown on the surface of the PDA plate Penicillium sp. TR85 (size 2×2 cm), inoculate into sterilized Erlenmeyer flasks filled with solid medium, and culture at room temperature for 30 days. The fermentation product is repeatedly soaked and extracted in ethyl acetate, and the combined extracts are concentrated to obtain a fermented crude extract.
[0032] The solid medium contains 100 g of rice and 0.6 g of peptone per 100 mL of natural seawater.
[0033] 2) Preparation of compounds
[0034] The above fermented crude extract was subjected to vacuum silica gel column chromatography (inner diameter 65 mm, length 300 mm, glass chromatography column with sand plate and suction nozzle), in the order of increasing polarity of the eluent, with a gradient of 40:1 Petroleum ether-ethyl acetate to 1:1 (v / v, the same b...
Embodiment 2
[0042] Example 2: Herbicidal activity test.
[0043]The agar mixed powder method established by Luo Xiaoyong et al. [Journal of Qingdao Agricultural University, 2007, 24: 267-270] is used to quickly determine the herbicidal activity of compounds, and has the advantages of high sensitivity, simple operation, good repeatability, and convenient for large-throughput screening. , and it is easy to observe and indicate the growth status of plants. Luo Xiaoyong et al. used this method to quickly measure the herbicidal activity of 40 kinds of garden plant leaves. Zhang Lijuan [Plant Protection, 2016, 42: 63-66] and Su Fansheng [Applied Chemistry, 2014, 31: 290-295] used barnyardgrass as the test weed, and used the agar powder mixing method to quickly determine the corn stalks and imidazoles herbicidal activity of the compounds. Zhang Yun [Acta Microbiology, 2015, 55: 292-298] and Li Shuai [Journal of Agricultural and Food Chemistry, 2014, 62: 8997-9001] took Amaranthus retroflexus a...
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