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Fructus schisandrae quality detecting method based on spectrum-effect relationship

A quality testing method and testing method technology, applied in measuring devices, instruments, scientific instruments, etc., can solve problems such as the lack of research on the relationship between the pharmacodynamics and activity of Schisandra chinensis, and achieve the effects of avoiding individual deviation of animals, quickly clarifying antibacterial effects, and avoiding interference.

Active Publication Date: 2019-12-20
WUXI HOSPITAL OF CHINESE MEDICINE
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Problems solved by technology

[0003] At present, most of the quality standards for Schisandra are qualitative or quantitative analysis of a few active ingredients, and there is no research on the relationship between Schisandra and its medicinal activity, especially the method for detecting the pros and cons of antibacterial activity of Schisandra

Method used

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  • Fructus schisandrae quality detecting method based on spectrum-effect relationship

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Embodiment 1

[0025] 1. Establishment of a quality detection model for Schisandra chinensis based on spectrum-effect relationship

[0026] 1. Drugs and reagents

[0027] Schisandra chinensis (9 batches of medicinal materials origin and harvesting time are shown in Table 1) was identified as the dried mature fruit of Schisandra chinensis S. chinensis, a plant of Magnoliaceae, by the director of traditional Chinese medicine practitioner Hu Minmin of Wuxi Hospital of Traditional Chinese Medicine. Vancomycin (Spain Lilly Company, batch number C752996); citric acid (National Institute for Food and Drug Control, batch number 111679-201602); malic acid (National Institute for Food and Drug Control, batch number 190013-201001).

[0028] Table 1 Sources of medicinal materials of Schisandra chinensis

[0029]

[0030] Acetonitrile (U.S. Fisher Scientific Company, chromatographically pure); formic acid (U.S. Sigma-Aldrich Company, chromatographically pure); water (U.S. Millipore Company, ultrapure...

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Abstract

The invention discloses a fructus schisandrae quality detecting method based on a spectrum-effect relationship. The fructus schisandrae quality detecting method comprises the following steps that firstly, a UPLC-MS fingerprint spectrum of anti-MRSA in-vitro bacteriostatic active components of a to-be-detected fructus schisandrae test sample is established, a characteristic peak is screened, then the screened characteristic peak area is substituted into a spectrum-effect mathematical model for calculation, and the quality of the fructus schisandrae test sample is judged according to the resultobtained by calculation. According to the fructus schisandrae quality detecting method, the quality of a fructus schisandrae product is judged in the mode of combination of the fingerprint spectrum and the mathematical model, disturbance of third party factors can be avoided, complex pharmacology experiments are avoided, individual deviation of animals is avoided, and the antibacterial effect of the anti-MRSA active site of the fructus schisandrae can be basically determined quickly and clearly.

Description

technical field [0001] The invention belongs to the technical field of quality standard detection of traditional Chinese medicines, and in particular relates to a quality detection method of Schisandra chinensis based on spectrum-effect relationship. Background technique [0002] Schisandra chinensis (Turcz.) Baill. is the dried and mature fruit of Magnolia plant Schisandra chinensis (Turcz.) Baill. Its taste is sour, sweet, and warm in nature, and it belongs to the lung, heart, and kidney channels. Clinically, it is often used for chronic cough and dyspnea, nocturnal emission, enuresis, frequent urination, chronic diarrhea, spontaneous sweating, thirsty wounds, internal heat and thirst, palpitations and insomnia and other diseases. Existing studies have shown that Schisandra chinensis extracted with 70% ethanol is sequentially extracted by petroleum ether (60°C-90°C), chloroform and ethyl acetate in stages, and the ethyl acetate extraction components are separated from wat...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/86G01N30/88
CPCG01N30/06G01N30/8686G01N30/88
Inventor 卞振华袁晓航胡敏敏陈晓伟
Owner WUXI HOSPITAL OF CHINESE MEDICINE
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