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Application of trillium tschonoskii maxim saponin to preparation of medicines for protecting nerves

A technology for protecting nerves and trillium, applied in the field of biomedicine, can solve the problems of environmental safety risks, increase the difficulty and cost of treatment of waste liquid discharged by pharmaceutical factories, and long degradation cycle of small molecular compounds, so as to achieve the treatment of neurodegenerative diseases. Effect

Pending Publication Date: 2019-12-24
SOUTHWEST MEDICAL UNIVERISTY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many uncertainties in chemically synthesized small molecular compounds, especially after drug metabolism enters the environment. Since such small molecular compounds do not exist in nature, small molecular compounds have a long degradation cycle in the natural environment, and there are environmental safety risks.
In addition, the process of synthesizing small molecular compounds requires the use of a large amount of organic solvents, and a large number of by-products will be produced during the synthesis process. The waste liquid and by-products in the synthesis process will increase the difficulty in the treatment of waste liquid discharged by pharmaceutical factories. and processing costs

Method used

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  • Application of trillium tschonoskii maxim saponin to preparation of medicines for protecting nerves
  • Application of trillium tschonoskii maxim saponin to preparation of medicines for protecting nerves
  • Application of trillium tschonoskii maxim saponin to preparation of medicines for protecting nerves

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Experimental program
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Embodiment Construction

[0060] 1. Test equipment and equipment

[0061] An Agilent 6230 mass spectrometer equipped with a DAD detector was used to detect the UV and HRMS spectra of DTCA and ETCA through electrospray ionization (ESI) time of flight (TOF).

[0062] Using Bruker Ascend 600 nuclear magnetic resonance instrument, TMS as the internal standard, respectively detected 1 H NMR (600MHz) and 13 C NMR (150MHz) nuclear magnetic resonance spectrum. Among them, the chemical shift is expressed in δ (ppm), and the coupling constant (J) is given in Hertz (Hz).

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Abstract

The invention discloses an application of trillium tschonoskii maxim steroid saponin to preparation of medicines for protecting nerves. Steroid saponin DTCA and steroid saponin ETCA obtained through extraction from trillium tschonoskii maxim are used as active components to be used for activating autophagy revulsants having high-efficacy oxidation resisting effects, through autophagy, oxidation resisting stress response is promoted, the cell viability is increased, the intra-cellular ROS level of damaged PC12 cell induced by H2O2 is reduced, the nerve is protected, and the potential of treating neural degeneration diseases is exerted.

Description

Technical field [0001] The invention relates to the application of a natural drug compound, in particular to the application of trillium saponin in neuroprotective drugs, and belongs to the technical field of biomedicine. Background technique [0002] Trillium (Trillium Tschonoskii Maxim, TTM), also known as "Yanling Grass", belongs to the genus Trillium (liliaceae), and is a herb distributed in central and western China. The dried roots and rhizomes of Trillium are widely used in traditional Chinese medicine to treat neurasthenia, cancer, headache, inflammation (such as ulcer), rheumatic pain, etc. [0003] Modern pharmacological research has found that natural steroidal saponins have a variety of biological activities, such as anti-cancer, anti-inflammatory, antibacterial and antiviral. Steroid saponins are widely present in plants, such as natural steroid saponins extracted from plants such as Smilax, Solanum paniculatum L., Furcraeahexapetala Leaves, Hosta plantaginea Rhizomes...

Claims

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Application Information

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IPC IPC(8): A61K31/58A61P25/00A61P25/28C07J21/00
CPCA61K31/58A61P25/00A61P25/28C07J21/00
Inventor 吴安国罗婉君秦大莲黄锦伟吴建明唐勇余录滕金凤邱文乔
Owner SOUTHWEST MEDICAL UNIVERISTY
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