Composition for disintegrating tablets containing microfibrous cellulose and active ingredient

An active ingredient, a technology for disintegrating tablets, applied in the field of compositions for disintegrating tablets, can solve problems such as non-containing, and achieve the effects of excellent formability, excellent tablet hardness and disintegration or dispersibility

Pending Publication Date: 2019-12-24
DAICEL CHEM IND LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, active ingredients such as medicinal ingredients are not substantially contained in the solid preparation
Also, nothing is said about the disintegration of the prepared tablets

Method used

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  • Composition for disintegrating tablets containing microfibrous cellulose and active ingredient
  • Composition for disintegrating tablets containing microfibrous cellulose and active ingredient
  • Composition for disintegrating tablets containing microfibrous cellulose and active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] [Preparation 1 of disintegrating particle composition]

[0089] 270 g of licorice (licorice powder, Matsuura Pharmaceutical Co., Ltd.) was put into a fluidized bed granulator (FL-LABO, Freund Sangyo Co., Ltd.), and the wet body of microfibrous cellulose (CELISH FD200L, Daicel FineChem Co., Ltd.) was diluted to 5%, and 600 g of the obtained CELISH suspension was sprayed at a rate of 4 g / min to perform granulation to obtain a disintegrating particle composition 1 .

[0090] [Preparation of disintegrating tablet 1]

[0091] The resulting disintegrating particle composition 1 was tableted using a simple tablet molding machine (HANDTAB-100, Ichihashi Seiki Co., Ltd.) under the tableting compression force listed in Table 1 to obtain a flat-angle tablet with a diameter of 8.0 mm. Tablets, tablets weighing 200mg.

Embodiment 2

[0093] [Preparation 2 of disintegrating particle composition]

[0094] 270 g of licorice (licorice powder, Matsuura Pharmaceutical Co., Ltd.) was put into a fluidized bed granulator (FL-LABO, Freund Sangyo Co., Ltd.), using the method described in Japanese Patent Application Laid-Open No. 2007-231438. The wet body of microfibrous cellulose (7% viscosity, 960mPa·s) produced by cellulose (CeolusPH-102, Asahi Kasei Chemicals Co., Ltd.) was diluted to 5%, and 600g of the resulting suspension was sprayed at a speed of 4g / min. Thus, granulation was performed to obtain a disintegrating particle composition 2 .

[0095] [Preparation of disintegrating tablet 2]

[0096] The resulting disintegrating particle composition 2 was tableted using a simple tablet molding machine (HANDTAB-100, Ichihashi Seiki Co., Ltd.) under the tableting compression force listed in Table 1 to obtain a flat-angle tablet with a diameter of 8.0 mm. Tablets, tablets weighing 200mg.

Embodiment 3

[0098] [Preparation of disintegrating particle composition 3]

[0099] 270 g of licorice (licorice powder, Matsuura Pharmaceutical Co., Ltd.) was put into a fluidized bed granulator (FL-LABO, Freund Sangyo Co., Ltd.), using the method described in Japanese Patent Application Laid-Open No. 2007-231438. The wet body (7% viscosity, 670mPa s) of the microfibrous cellulose produced by cellulose (CeolusKG-802, Asahi Kasei Chemicals Co., Ltd.) was diluted to 5%, and 600g of the resulting suspension was sprayed at a speed of 4g / min. Granulation was performed in this manner to obtain a disintegrating particle composition 3 .

[0100] [Preparation of disintegrating tablet 3]

[0101] The resulting disintegrating particle composition 3 was tableted using a simple tablet molding machine (HANDTAB-100, Ichihashi Seiki Co., Ltd.) under the tableting compression force listed in Table 1 to obtain a flat-angle tablet with a diameter of 8.0 mm. Tablets, tablets weighing 200mg.

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Abstract

Using the exceptional characteristics of microfibrous cellulose, the invention provides, inter alia: a variety of disintegrating tablets having a variety of purposes and applications such as drugs, herbal medicines, foods, etc., containing high concentrations of various active ingredients such as medicinal ingredients, nutritional ingredients, and supplements and food ingredients; and compositionsfor the disintegrating tablets. A composition for disintegrating tablets containing an active ingredient and a disintegrant ingredient comprising only microfibrous cellulose, and disintegrating tablets for foods or drugs containing the composition for disintegrating tablets are disclosed.

Description

technical field [0001] The present invention relates to a composition for disintegrating tablets containing various active ingredients such as medicinal ingredients, nutritional ingredients, supplements / food ingredients, and a disintegrant ingredient consisting only of microfibrous cellulose; and a composition containing the composition Various disintegrating tablets, etc. Background technique [0002] Cellulose produced from plant fibers and having a fiber diameter (short diameter) or thickness of several nm to several μm is generally called "microfibrous cellulose" (or "fine fibrous cellulose"). Preparation examples of such fine fibrous cellulose and its structure / properties / functions are described in Patent Document 1 and Patent Document 2. [0003] These micronized or microfibrillated cellulose do not impair the basic properties (physical and chemical stability, etc.) of cellulose as a raw material, but the surface area is significantly increased, and the hydrophilicity...

Claims

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Application Information

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IPC IPC(8): A61K47/38A61K9/20A61K47/26
CPCA61K9/2054A61K9/0095A61K9/2018A61K9/0056A61K9/2095A61K31/07A61K31/7004A61K31/7008A61K36/07A61K36/31A61K36/484A61K36/65A61K36/82A61K36/8998
Inventor松冈美绪桥川尚弘浜崎桃子泷川嘉久
OwnerDAICEL CHEM IND LTD