Targeted drug delivery system for double-effect treatment and preparation method and application of targeted drug delivery system

A delivery system and drug technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, nano-drugs, etc., can solve the problems of too fast drug release, no substantial solution, side effects of chemotherapy, etc.

Active Publication Date: 2020-01-07
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current cancer-related chemotherapeutic drugs have shown the following two shortcomings: (1) due to the single mechanism of action of most drugs, long-term use is prone to produce drug-resistant cell lines leading to cancer recurrence; (2) because most drugs cannot be targeted Drug delivery in the body can cause strong side effects of chemotherapy
Targeted drugs can effectively increase the selectivity of drugs, but there are still two obvious deficiencies: (1) the problem of a single drug action mechanism has not been substantially resolved; (2) the drug loading of nanostructures for drug delivery at this stage Generally relatively low, and because the active ingredients are limited to the anticancer drugs carried, it will eventually lead to an increase in the dosage
However, the drug release of these drug delivery systems is often too fast and cannot effectively prevent the drug from being released during the delivery process.

Method used

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  • Targeted drug delivery system for double-effect treatment and preparation method and application of targeted drug delivery system
  • Targeted drug delivery system for double-effect treatment and preparation method and application of targeted drug delivery system
  • Targeted drug delivery system for double-effect treatment and preparation method and application of targeted drug delivery system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0093] Cobalt-containing framework DOX@Co 0.8 Zn 0.2 - Preparation of ZIF drug delivery system

[0094] Weigh raw materials: the molar ratio of cobalt nitrate to zinc nitrate is 4:1, the molar ratio of 2-methylimidazole to the total amount of metal elements is 100:1, the mass ratio of PVP to 2-methylimidazole is 0.1:1, and Adriamycin The mass fraction of the element in the final drug delivery system was 17%.

[0095] The concrete steps of preparation are:

[0096] (1) Dissolve an appropriate amount of doxorubicin in distilled water to obtain 5 mg·mL -1 adriamycin solution. will respectively contain a concentration of 0.08 mol·L -1 of cobalt nitrate and a concentration of 0.02mol L -1 The mixed solution of zinc nitrate and doxorubicin were mixed, and stirred for 12 minutes according to the rotating speed of 800rpm to obtain solution A;

[0097] (2) Add 2-methylimidazole and polyvinylpyrrolidone (PVP) into 10 times the amount of distilled water, and stir at 400 rpm for...

Embodiment 2

[0100] Copper-containing framework DOX@Cu 0.01 Ag 0.95 -Preparation of ZIF targeted drug delivery system

[0101] Weigh raw materials: the molar ratio of copper nitrate to silver nitrate is 1:95, the molar ratio of terephthalic acid to the total amount of metal elements is 10:1, the mass ratio of polyvinyl alcohol to terephthalic acid is 0.01:1, carboplatin The mass fraction in the final drug delivery system is 8%.

[0102] The concrete steps of preparation are:

[0103] (1) Dissolve an appropriate amount of carboplatin in distilled water to obtain 8 mg·mL -1 carboplatin solution. Will contain concentration 0.05mol·L respectively -1 Copper nitrate and concentration 0.95mol L -1 The mixed solution of silver nitrate and the carboplatin solution were mixed, and stirred for 8 minutes according to the rotating speed of 2000rpm to obtain solution A;

[0104] (2) Add terephthalic acid and polyvinyl alcohol into 10 times the amount of distilled water, and stir at 400 rpm for...

Embodiment 3

[0107] Nickel-containing skeleton DOX@Ni 0.5 co 0.5 -Preparation of ZIF targeted drug delivery system

[0108] Weigh the raw materials: the molar ratio of copper nitrate to nickel sulfate is 1:1, the molar ratio of 1,4-bis(1H-pyrazol-4-yl)benzene to the total amount of metal elements is 200:1, polyvinyl alcohol 400 and 1 , the mass ratio of 4-bis(1H-pyrazol-4-yl)benzene is 0.5:1, and the mass fraction of bleomycin in the final drug delivery system is 20%.

[0109] The concrete steps of preparation are:

[0110] (1) Dissolve an appropriate amount of bleomycin in distilled water to obtain 3 mg·mL -1 bleomycin solution. will respectively contain a concentration of 0.05mol L -1 Copper nitrate and the concentration of 0.05mol L -1 The mixed solution of nickel sulfate and the bleomycin solution were mixed, and stirred for 10min according to a rotating speed of 1000rpm to obtain solution A;

[0111] (2) Add 1,4-bis(1H-pyrazol-4-yl)benzene and 2 polyethylene glycol 400 to 10 ti...

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Abstract

The invention relates to the technical field of anti-cancer drugs, in particular to a targeted drug delivery system for double-effect treatment and a preparation method and application of the targeteddrug delivery system. The targeted drug delivery system is prepared from the following components of a metal-organic framework and an anti-cancer drug, wherein the metal-organic framework has the cancer cell killing effect. The targeted drug delivery system for double-effect treatment has the advantages that various anti-cancer mechanisms are included, pertinence is high, and the drug loading capacity is large.

Description

technical field [0001] The invention relates to the technical field of anticancer drugs, in particular to a targeted drug delivery system for dual-effect therapy and its preparation method and application. Background technique [0002] In medicine, cancer refers to malignant tumors originating from epithelial tissue, and is the most common type of malignant tumors. Generally speaking, "cancer" generally refers to all malignant tumors. Cancer has biological characteristics such as abnormal cell differentiation and proliferation, out-of-control growth, invasion, and metastasis. Infection, occupational exposure, environmental pollution, unreasonable diet, and genetic factors are closely related. [0003] Cancer is one of the biggest disease threats facing human beings. The incidence of cancer has been on the rise in the past 30 years. According to the report of the World Health Organization (WHO), the average annual new cancer cases in China are about 2.2 million, and the num...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K9/14A61K47/32A61K45/06A61K31/555A61K31/704A61K33/24A61K33/30A61K33/34A61K33/38A61K38/14A61P35/00B82Y5/00B82Y40/00A61K9/51
CPCA61K9/146A61K9/19A61K9/5138A61K31/555A61K31/704A61K33/24A61K33/30A61K33/34A61K33/38A61K38/14A61K45/06A61P35/00B82Y5/00B82Y40/00A61K2300/00
Inventor 戈钧卢元王力铖侯涵译焦馨琪沈天寅
Owner TSINGHUA UNIV
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