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Apparatus for dissolving reagents in fluids in capillary-driven microfluidic systems

A microfluidic system, capillary technology, applied in the field of devices for dissolving reagents in fluids in capillary-driven microfluidic systems, can solve the problems of difficult fabrication and implementation of fluidic components

Active Publication Date: 2021-12-07
MIDIAGNOSTICS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Reagent distribution can be aided by active fluidic elements such as mixers, but these are difficult to fabricate and implement

Method used

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  • Apparatus for dissolving reagents in fluids in capillary-driven microfluidic systems
  • Apparatus for dissolving reagents in fluids in capillary-driven microfluidic systems
  • Apparatus for dissolving reagents in fluids in capillary-driven microfluidic systems

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Embodiment Construction

[0009] The aim is to at least partly solve the above-mentioned problems of the prior art. In particular, the aim is to achieve uniform dissolution of dry reagents in fluids in capillary-driven microfluidic systems.

[0010] According to a first aspect, the above object is achieved by a device for dissolving a reagent in a fluid in a capillary driven microfluidic system, the device comprising:

[0011] a channel for receiving fluid at the first end,

[0012] a valve arranged at the second end of the channel to control fluid flow to stop when it reaches the second end of the channel,

[0013] one or more structures for holding dry reagents,

[0014] the one or more structures each have a width greater than the width of the channel, and

[0015] The one or more structures are fluidly coupled to the channel such that the fluid is allowed to enter the one or more structures from the channel, dissolve and diffuse dry reagents held therein back into the channel, and

[0016] An a...

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Abstract

An apparatus for dissolving a reagent in a fluid in a capillary driven microfluidic system is provided. The device (200) comprises: a channel (102) for receiving fluid at a first end; a valve (105) arranged at a second end of the channel in order to control the flow of fluid at the point at which it reaches the channel and an actuator (108) for opening the valve (105) at a predetermined time after receiving the fluid from the channel (102). The device further includes one or more structures (106) for holding dry reagents. The one or more structures (106) each have a width (W2) greater than the width (W1) of the channel (102), and the one or more structures are coupled to the side walls of the channel such that the fluid is allowed to enter from the channel The one or more structures dissolve and diffuse the dried reagents held therein back into the channel.

Description

technical field [0001] The present disclosure relates to capillary-actuated microfluidic systems. In particular, the present disclosure relates to a device for dissolving reagents in a fluid in a capillary driven microfluidic system. Background technique [0002] The integration of reagents into microfluidic devices is critical for applications in diagnostics and life sciences. One approach to integrating reagents on-chip in a microfluidic device, allowing the device to have a longer shelf life, is to store dry reagents on-chip and dissolve them with buffer fluid or sample fluid when testing is performed. In this approach, the challenge is to achieve precise conditions such as volume and concentration in reagent dissolution. Given the low Reynolds number flow conditions (as is the case in the microfluidic device range), the dissolution of reagents on microfluidic devices can be extremely fast and can lead to accumulation of reagents at the front of the fill liquid, leading...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/50273B01L3/502738B01L3/523B01L2200/16B01L2400/0406B01L2400/0688B01L3/527
Inventor 张磊
Owner MIDIAGNOSTICS NV