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Wingedtooth laggera herb solution preparation for inhalation and preparation method of wingedtooth laggera herb solution preparation

A technology of lingdancao and stinky lingdancao, which is applied in the field of pharmacy, can solve the problems of non-existence and achieve the effects of fast absorption, reduced dosage, and low production cost

Pending Publication Date: 2020-02-04
INCREASEPHARM HENGQIN INST CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prescription of Stomach Dancao has anti-inflammatory and analgesic functions, and is suitable for development as an aerosol inhalation solution preparation for respiratory or pulmonary administration. Compared with existing preparations, it is expected to have better curative effect and lower side effects. But in the prior art, there is no special atomized inhalation preparation for prescription inhalation of Stomadaria

Method used

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  • Wingedtooth laggera herb solution preparation for inhalation and preparation method of wingedtooth laggera herb solution preparation
  • Wingedtooth laggera herb solution preparation for inhalation and preparation method of wingedtooth laggera herb solution preparation
  • Wingedtooth laggera herb solution preparation for inhalation and preparation method of wingedtooth laggera herb solution preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]

[0035]Take 50g of Panacea, steam distillation to collect volatile oil, filter the distilled aqueous solution, and set aside the filtrate, decoct the dregs with water for 2 times, each time for 1 hour, filter, combine the filtrate with the above-mentioned distilled filtrate, and depressurize Concentrate to about 800ml, add ethanol to make the alcohol content reach 80%, stir well, and refrigerate for 24 hours; filter, recover ethanol, add water to make up to 1000ml, pass through the treated macroporous resin column, and wash with 4 times the amount of water first , and then eluted with 4 times the amount of 20%-60% ethanol, collected the eluate, refluxed the ethanol, and dried under reduced pressure to obtain the extract.

[0036] Take the extract and dissolve it in water, let it stand for more than 24 hours, filter, add 0.1% activated carbon to boil for 30 minutes, filter, ultra-filter, then add volatile oil and Tween 80, and add water to make up to 1000mL, stir well...

Embodiment 2

[0038]

[0039] Take 200g of Panacea, steam distillation to collect volatile oil, filter the distilled aqueous solution, and set aside the filtrate, decoct the dregs with water for 2 times, each time for 1.5 hours, filter, combine the filtrate with the above-mentioned distilled filtrate, and depressurize Concentrate to about 800ml, add ethanol to make the alcohol content reach 80%, stir well, and refrigerate for 24 hours; filter, recover ethanol, add water to make up to 1000ml, pass through the treated macroporous resin column, and wash with 4 times the amount of water first , and then eluted with 5 times the amount of 20%-60% ethanol, collected the eluate, refluxed the ethanol, and dried under reduced pressure to obtain the extract.

[0040] Take the extract and dissolve it in water, let it stand for more than 24 hours, filter, add 0.2% activated carbon to boil for 30 minutes, filter, ultra-filter, then add volatile oil and Tween 80, and add water to make up to 1000mL, stir...

Embodiment 3

[0042]

[0043] Take 250g of Stinking Dancao, steam distillation to collect volatile oil, filter the distilled aqueous solution, and set aside the filtrate, decoct the dregs with water for 2 times, each time for 1 hour, filter, combine the filtrate with the above-mentioned distilled filtrate, and depressurize Concentrate to about 800ml, add ethanol to make the alcohol content reach 80%, stir well, and refrigerate for 24 hours; filter, recover ethanol, add water to make up to 1000ml, pass through the treated macroporous resin column, and wash with 4 times the amount of water first , and then eluted with 6 times the amount of 20%-60% ethanol, collected the eluate, refluxed the ethanol, and dried under reduced pressure to obtain the extract.

[0044] Take the extract and dissolve it in water, let it stand for more than 24 hours, filter, add 0.2% activated carbon to boil for 30 minutes, filter, ultra-filter, then add volatile oil and Tween 80, and add water to make up to 1000mL,...

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Abstract

The invention provides a wingedtooth laggera herb solution preparation for inhalation and a preparation method of the wingedtooth laggera herb solution preparation. The wingedtooth laggera herb solution preparation for inhalation has excellent physical performance parameters and is easy to atomize to form aerosol, and further has the advantages of reliable quality, high safety, high stability andlong storage time. According to the preparation method, the number of extraction of active ingredients is small, the extraction time is short, the operation is simple and easy, and the production costis low.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a panacea solution preparation for inhalation and a preparation method thereof. Background technique [0002] The traditional Chinese medicine Laggera Herba (Laggera Herba), also known as Lion Grass, Smelly Leaf, Wild Spicy Tobacco, Guijing Grass, Yufu, etc., is a plant of the genus Hexagonal in the Asteraceae family. It is mainly distributed in the south and southwest of the Yangtze River Basin. in Yunnan Province, my country. Stinking Dancao has been used as folk medicine for more than 500 years. "Southern Yunnan Materia Medica" records that it can cure wind-heat accumulation, carbuncles, boils, and scabies; Swelling, treatment of pharyngitis, stomatitis, bronchitis, malaria, burns, snake bites; "Yunnan Chinese Herbal Medicine" records it: treatment of upper respiratory tract infection, tonsillitis, stomatitis, prevention and treatment of influenza; "Dictionary of Chinese Me...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/72A61K9/08A61K47/26A61P11/00A61P11/04A61P1/02A61P11/10A61P11/14
CPCA61K36/28A61K9/0078A61K9/08A61K47/26A61P11/00A61P11/04A61P1/02A61P11/10A61P11/14A61K2236/331A61K2236/39A61K2236/53A61K2236/51
Inventor 张保献胡杰王志华
Owner INCREASEPHARM HENGQIN INST CO LTD
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