Application of turmeric and rhzoma zingiberis purrurei stomach pain recipe to preparation of medicines for treating inflammatory bowel diseases

A technology of inflammatory bowel disease and pain formula, which is applied in the application field of Shuangjiang Weitong formula in the preparation of drugs for treating inflammatory bowel disease, and can solve the problems of insufficient exploration and utilization of medical applications

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A technology of inflammatory bowel disease and pain formula, which is applied in the application field of Shuangjiang Weitong formula in the preparation of drugs for treating inflammatory bowel disease, and can solve the problems of insufficient exploration and utilization of medical applications

CN110755594AActive Publication Date: 2020-02-07YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE

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[0020] The preparation method of Shuangjiang Weitong Recipe is as follows: Weigh turmeric, purple ginger, Diwurong, Shichangpu, bitter rapeseed according to the weight ratio of 1:1:1:1:1, and add 4-5 L per 500g of total medicinal materials. After soaking in ethanol, heating and refluxing, after filtering, the filter residue is extracted with ethanol for refluxing 2-3 times, the filtrate is combined, concentrated under reduced pressure and dried to obtain Shuangjiang stomach pain prescription.

[0021] The concentration of ethanol is 75%.

[0022] The drying method is vacuum drying under reduced pressure.

[0023] Application of Shuangjiang Weitong Recipe in the preparation of a medicine for treating ulcerative colitis.

[0024] Application of Shuangjiang Weitong Recipe in the preparation of drugs for treating colon inflammation in mice induced by sodium dextran sulfate.

[0025] Shuangjiang Weitong Recipe includes a therapeutically effective amount of Shuangjiang Weitong Recipe and a p...

Embodiment 1

[0029] Example 1 Preparation of Shuangjiang Weitong Recipe

[0030] Weigh 100 g each of turmeric, purple ginger, Diburong, calamus, and bitter rapeseed (500 g in total), put them in a 5 L round-bottomed flask, add 5 L of 75% ethanol, soak for 1 h, and use 5 L, 4L, 4L of 75% ethanol, each water bath refluxed and extracted once, the extraction time was 1.5 h, 1 h, 0.5 h, respectively, the three filtrates were combined, the ethanol was recovered under reduced pressure until there was no alcohol smell, placed in a vacuum drying oven, dried, and finely ground. The extract has an extraction rate of 43% and is ready for use.

Embodiment 2

[0032] Take the extract obtained in Example 1, concentrate, evaporate to dryness under reduced pressure, pulverize and sieve to obtain dry paste powder, and fill it into capsules to obtain capsules.

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Abstract

The invention discloses an application of a turmeric and rhzoma zingiberis purrurei stomach pain recipe to preparation of medicines for treating inflammatory bowel diseases. The turmeric and rhzoma zingiberis purrurei stomach pain recipe is a mixture which is obtained by performing mixing and extracting on turmeric, rhzoma zingiberis purrurei, delavay stephania roots, grassleaf sweetflag rhizomesand semen integrifoliae through the weight ratio relationship of 1:1:1:1:1. Tests prove that the turmeric and rhzoma zingiberis purrurei stomach pain recipe can notably improve mouse colitis diseasesinduced by dextran sulfate sodium, the activity indexes of mouse diseases can be notably reduced, and the mouse colon contraction in length caused by modeling can be obviously improved. The vitality of MPO in serum can be notably reduced, the content of proinflammatory factors IL-1 beta, IL-6 and IL-1 beta in colon tissues can be notably reduced, and the application has notable activity for resisting ulcerative colitis, and has favorable application prospects in preparation of medicines for treating inflammatory bowel diseases.

Description

Technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to the application of Shuangjiang Weitong Recipe in the preparation of a medicine for treating inflammatory bowel disease. Background technique [0002] The standard number of Shuangjiang Weitong Recipe WS-11105 (ZD-1105) -2002 is recorded in the Internal Medicine Spleen and Stomach Division of the National Standards of Chinese Patent Medicine. It is made from 200g of turmeric, 200g of purple ginger, 200g of Diwurong, 200g of Acorus calamus, and 200g of bitter rapeseed as raw materials. It has the effects of regulating qi and relieving pain, and reducing the adverse effects of the stomach. [0003] Shuangjiang Weitong Recipe is used for patients with gastric swelling, fullness, pain, belching and acid, chronic superficial gastritis caused by the stagnation of Qi in the middle Jiao, but its medical use has not been fully explored and utilized. Summary of the...

Claims

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Application Information

Patent Timeline

07 Feb 2020

Publication

CN110755594A

IPC: A61K36/9068; A61P29/00; A61P1/00

CPC: A61K36/28; A61K36/59; A61K36/888; A61K36/9066; A61K36/9068; A61K2236/333; A61K2236/39; A61P1/00

Inventors: 王亭; 郭雪艳