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Sample adding method of full-automatic chemiluminiscence immunoassay analyzer

An automatic chemical and luminescent immune technology, applied in the field of medical devices, can solve problems such as large bubbles, reduce the probability of hanging liquid, improve accuracy, and reduce the generation of bubbles

Active Publication Date: 2020-02-11
SUZHOU HYBIOME BIOMEDICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is: in order to solve the problem in the prior art that large bubbles will be generated when the sampling needle drains liquid, thereby providing a sample adding method for a fully automatic chemiluminescence immunoassay analyzer

Method used

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  • Sample adding method of full-automatic chemiluminiscence immunoassay analyzer
  • Sample adding method of full-automatic chemiluminiscence immunoassay analyzer
  • Sample adding method of full-automatic chemiluminiscence immunoassay analyzer

Examples

Experimental program
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Effect test

Embodiment 1

[0041] Such as figure 1 As shown, one end of the pipeline 7 is connected with a sampling needle 1, and the sampling needle 1 is inserted into the cuvette 4 for sample discharge. The air column 3 is used to isolate the cleaning solution, and the lower air column prevents the liquid from being thrown off by the needle tip.

[0042] This embodiment provides a method for adding samples to a fully automatic chemiluminescence immunoassay analyzer, such as figure 2 shown, including the following steps:

[0043] S1: Move the sampling needle to the bottom of the cuvette for the first sample discharge;

[0044] Each time the sampling needle discharges a sample, the discharge volume of the sample is recorded;

[0045] S2: According to the sum of the previous discharge volume V 1 , and calculate the height h of the liquid level in the cuvette according to the cross-sectional area S of the cuvette, h=V 1 / S;

[0046] S3: Obtain the discharge volume V of the sample liquid to be disch...

Embodiment 2

[0064] This embodiment provides a method for adding samples to a fully automatic chemiluminescence immunoassay analyzer, such as figure 2 shown, including the following steps:

[0065] S1: Move the sampling needle to the bottom of the cuvette for the first sample discharge;

[0066] Each time the sampling needle discharges a sample, the discharge volume of the sample is recorded;

[0067] S2: According to the sum of the previous discharge volume V 1 , and calculate the height h of the liquid level in the cuvette according to the cross-sectional area S of the cuvette, h=V 1 / S;

[0068] S3: Obtain the discharge volume V of the sample liquid to be discharged 2 ;

[0069] S4: Determine the displacement V 2 Whether it exceeds the discharge volume threshold that will generate bubbles; if it exceeds the discharge volume threshold, go to S51; if it does not exceed the discharge volume threshold, go to S52;

[0070] S51: Control the needle tip of the sampling needle to move to...

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Abstract

The invention relates to a sample adding method of a full-automatic chemiluminiscence immunoassay analyzer. The sample adding method comprises the steps of: S1, recording a liquid amount during each sample discharge, and calculating a liquid level height according to the sectional area of the reaction cup, wherein the liquid amount in a current reaction cup is a sum of previous sample discharge; S2, moving a sampling needle to a position X mm above the liquid level to ensure that a lower air column is discharged above the liquid level; S3, distinguishing according to a to-be-drained liquid amount, if the liquid amount is large, discharging a liquid and an upper air column in situ and lifting the sampling needle to prevent the needle tip from being submerged by the liquid too much, and if the liquid amount is small, moving the sampling needle downwards continuously to a position Y mm below the liquid level and discharging the liquid and the upper air column statically to ensure that theliquid at the needle tip is in contact with the liquid in the reaction cup and can be discharged completely; S4, and returning the sampling needle back to a zero point in the vertical direction afterthe discharging process is finished, and performing subsequent actions continuously. The sample adding method can effectively reduce the generation of bubbles, and reduce the probability of liquid hanging on the inner wall of the reaction cup caused by bubble burst, thereby improving the accuracy of test results.

Description

technical field [0001] The application belongs to the technical field of medical devices, and in particular relates to a sample adding method for a fully automatic chemiluminescence immunoassay analyzer. Background technique [0002] At present, in the current fully automatic chemiluminescence instruments, when drawing reagents or samples, there are usually upper and lower air columns. The upper air column is used to isolate the cleaning solution, and the lower air column prevents the liquid from being thrown by the needle tip and pollutes the table. The survey found that when some fully automatic chemiluminescent immunoassay analyzers arrange samples, in order to avoid unclean reagents or samples, they often use submerged sample arrangement. During sample discharge, many devices in the industry use liquid level detection to position the sampling needle. This method relies too much on the sensitivity of liquid level detection. When the sensitivity is too high, false detectio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N35/10G01N33/53
CPCG01N33/5302G01N35/1009
Inventor 吴国银黄海进尤文艳
Owner SUZHOU HYBIOME BIOMEDICAL ENG CO LTD