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Bladder cancer biomarker TJP1 and application thereof

A biomarker and bladder cancer technology, applied in the field of biomedicine, can solve the problem of whether the relationship between bladder cancer has not been clarified

Active Publication Date: 2020-04-07
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the development of research, the abnormal expression of TJP1 in different tumors and its role in tumor metastasis and invasion have been gradually discovered. However, whether there is a link between TJP1 and bladder cancer has not yet been clarified.

Method used

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  • Bladder cancer biomarker TJP1 and application thereof
  • Bladder cancer biomarker TJP1 and application thereof
  • Bladder cancer biomarker TJP1 and application thereof

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Embodiment Construction

[0029] In order to facilitate the understanding of the present invention, the following will describe the present invention more fully and give preferred embodiments of the present invention. However, the present invention can be embodied in many different forms and is not limited to the embodiments described herein. On the contrary, these embodiments are provided to make the understanding of the disclosure of the present invention more thorough and comprehensive.

[0030] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the technical field of the invention. The terms used herein in the description of the present invention are for the purpose of describing specific embodiments only, and are not intended to limit the present invention. As used herein, the term "and / or" includes any and all combinations of one or more of the associated listed items.

[0031] 1. Correlation analysis...

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Abstract

The invention relates to a bladder cancer biomarker TJP1 and application thereof. According to the invention, the expression quantity of the TJP1 in bladder cancer tissue is found to be obviously andpositively correlated with the expression of a tumor malignant degree index KI67, which indicates that the TJP1 can be used as an index of the malignant degree of the bladder cancer to predict the occurrence and development of the bladder cancer. The influence of knock-down of the TJP1 on vasculogenic mimicry of the bladder cancer is detected through 3D culturing; and it is found that the effect of vasculogenic mimicry can be obviously reduced after TJP1 is knocked down, and the effect of vasculogenic mimicry can be enhanced through TJP1 overexpression, so it is indicated that TJP1 obviously influences the effect of early angiogenesis of the bladder cancer and thus influences the occurrence and development of the bladder cancer. After the TJP1 is knocked down, the angiogenesis and vasculogenic mimicry effects of tumorigenesis of nude mice can be obviously inhibited, so it is prompted that the TJP1 can be used as a biomarker for the occurrence and development of the bladder cancer.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a bladder cancer biomarker TJP1 and its application. Background technique [0002] Bladder cancer is the most common malignant tumor in the urinary system. It is very important for the treatment of bladder cancer to find the regulatory factors that significantly affect the development, metastasis and recurrence of bladder cancer and to study the specific mechanism of its action. Various studies on the mechanism of bladder cancer treatment have shown that the occurrence and development of bladder cancer is an extremely complicated process. In the past 30 years, no targeted drugs have been approved for the treatment of bladder cancer, and research progress is urgently needed to improve bladder cancer. level of diagnosis and treatment. Therefore, finding diagnostic markers for bladder cancer, screening for high-risk groups, and finding reasonable drug regimens to improve the su...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886C12N15/113C12N15/11C07K16/28G01N33/574G01N33/577
CPCC12Q1/6886C12N15/1138C07K16/28G01N33/57407G01N33/57484G01N33/577C12Q2600/158C12Q2600/118C12N2310/14G01N2333/705C12N2310/531
Inventor 张幸鼎刘雪琦李淼邵欣荣齐琳潘纪安
Owner SUN YAT SEN UNIV
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