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Hyaluronic acid-containing composition as well as preparation method and application thereof

A technology of hyaluronic acid and composition, applied in the field of daily chemicals, can solve the problems of limiting the anti-allergic effect of potassium ions, irritation, affecting experience, etc., and achieve the effect of avoiding the reduction of desensitization effect and avoiding neural adaptability.

Active Publication Date: 2020-04-10
CHONGQING DENCARE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of potassium ions to combat tooth sensitivity also has the following technical problems: after the oral care products containing potassium ions are applied to the teeth, a small amount of potassium ions enter the dentinal tubules and enter the dental pulp to inhibit the excitability of nerve fiber endings. Over time, the potassium ions in the dentinal tubules are transferred or absorbed by the surrounding tissue, and the potassium ions cannot act on the nerve endings for a long time, which limits the anti-sensitivity effect of potassium ions
Moreover, potassium ions are irritating to the pulp nerve and the tissues around the teeth, which affects consumers' experience when using products containing potassium ions.

Method used

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  • Hyaluronic acid-containing composition as well as preparation method and application thereof
  • Hyaluronic acid-containing composition as well as preparation method and application thereof
  • Hyaluronic acid-containing composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The preparation method of Example 1: Stir water and glycerin evenly, then add sodium saccharin, hyaluronic acid, potassium nitrate, cetylpyridinium chloride, and mix evenly; then slowly add essence, sorbitol, and poloxa while stirring Mix evenly, filter and pack, and the mouthwash is prepared.

Embodiment 15-17

[0045] Embodiment 15-17 is toothpaste preparation example

[0046] The toothpaste is prepared by using the composition of the invention, and the toothpaste includes the following raw materials in parts by weight: 0.05-5 parts of hyaluronic acid, 0.1-5 parts of potassium nitrate, and 0.01-1 part of cetylpyridinium chloride. Hyaluronic acid, potassium nitrate and cetylpyridinium chloride can be combined according to the mass ratio of 0.05:0.1:0.01, or can be combined according to the mass ratio of 5:5:1, or can be combined according to 2:2:0.5, and then this The composition formed by the three substances is used in toothpaste. Specifically, the composition and preparation of toothpaste are illustrated by Examples 15-17, wherein, more optimized, the toothpaste includes the following raw materials in parts by weight: 0.05-5 parts of hyaluronic acid, 0.1-5 parts of potassium nitrate, 0.01 parts of cetylpyridinium chloride -1 part, 1-70 parts of moisturizing agent, 0.1-10 parts of ...

experiment example 1

[0053] Experimental example 1: clinical desensitization effect experiment

[0054] In this experimental example, the mouthwash containing the composition of the present invention was used to carry out the desensitization test. The toothpaste containing the composition of the present invention also has an anti-allergic effect, which is not repeatedly listed in the experimental example. Use the mouthwashes in Table 1 (Examples 1-11, Comparative Examples 1-7) to conduct clinical tests on alleviating dentin sensitivity, with 33 people in each group. All subjects received 3 routine oral examinations and dentine sensitivity tests, and at least 2 teeth of the subjects were clinically diagnosed as dentine hypersensitivity and recorded. Dentin sensitivity test using cold air stimulation method. Check at room temperature, use a gun 1cm away from the tooth surface, stimulate the tooth surface with standard pressure air for 1 second, and stimulate the exposed root surface with cold air, ...

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Abstract

The invention belongs to the field of daily chemicals, and particularly relates to a hyaluronic acid-containing composition as well as a preparation method and application thereof. The hyaluronic acid-containing composition includes hyaluronic acid, potassium ions, and cetylpyridinium chloride. The three components are compounded to achieve a synergistic effect, so the hyaluronic acid-containing composition has good effects of relieving dentin sensitivity, inhibiting bacteria, diminishing inflammation and repairing oral mucosa, and can reduce the irritation of potassium ions to dental pulp nerves and surrounding tissues of teeth. An oral cavity product prepared from the composition is non-irritant in taste and good in user experience, and has wide application prospects.

Description

technical field [0001] The invention belongs to the field of daily chemicals, and in particular relates to a hyaluronic acid-containing composition and a preparation method and application thereof. Background technique [0002] Dentine hypersensitivity (Dentine hypersensitivity) refers to the symptoms of soreness when teeth are stimulated by external temperature, chemical substances or mechanical action. The mechanism of tooth sensitivity is roughly as follows: tooth wear, tooth root exposure and gingival recession make the dentin exposed. Due to the open state of the dentinal tubules, under external stimuli, the liquid in the dentinal tubules moves, mechanically agitating the pulp content, and indirectly stimulating the nerve endings in the pulp, resulting in sensitivity symptoms. The mechanism of action of anti-allergic oral care products is mainly to improve the anti-acid ability of teeth, block dentinal tubules and inhibit the excitability of nerve endings. Among them,...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61K8/19A61K8/20A61K8/24A61K8/63A61K8/36A61K8/362A61K8/49A61Q11/00A61P1/02A61P29/00A61P31/02A61P31/04A61P31/10
CPCA61K8/735A61K8/19A61K8/20A61K8/24A61K8/63A61K8/36A61K8/362A61K8/4926A61Q11/00A61P1/02A61P29/00A61P31/02A61P31/04A61P31/10A61K2800/592Y02A50/30
Inventor 张红张旻陈凤邓全富舒盈盈宫敬禹邓嵘
Owner CHONGQING DENCARE CORP
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