Novel entrainment type medicine preparation method based on supercritical CO2 extraction

Abstract

The invention discloses a novel entrainment type medicine preparation method based on supercritical CO2 extraction, belonging to the field of supercritical pharmaceutical technology. According to theinvention, a novel entrainer mixing mode is employed; most of an entrainer is injected into a centrifugal sustained-release ball, a small part of the entrainer is premixed with supercritical CO2; during extraction, a centrifugal rotation mode is adopted, the injected entrainer is slowly released into medicinal material powder and fully contacted with the medicinal material powder under the actionof extrusion, and the medicinal material powder is driven to continuously overturn, so a reaction is fully and comprehensively carried out under the atmosphere of supercritical CO2, the extraction properties of the entrainer are obviously improved, extraction efficiency is enhanced, effective components in medicinal materials are improved in solubility and sensitivity to temperature and pressure,and the separated components are separated from circulation gas through temperature and pressure so as to avoid high energy consumption caused by re-compression of gas; and the entrainer can even be used as a co-surfactant to facilitate the formation of a supercritical fluid micro-emulsion and has great advantages in the extraction of bioactive components in medicinal materials.

Description

technical field [0001] The invention relates to the technical field of supercritical pharmacy, and more specifically, relates to a novel entrainment pharmacy method based on supercritical CO2 extraction. Background technique [0002] Supercritical fluid extraction is a new type of extraction and separation technology. It uses a supercritical fluid, that is, a fluid in a thermodynamic state with a temperature higher than the critical temperature and a pressure higher than the critical pressure, as the extraction agent. Extract specific components from liquids or solids for separation purposes. The characteristics of supercritical fluid extraction are: the extractant is a gas at normal pressure and room temperature, and it is easy to separate from the raffinate phase and the extraction group after extraction; it operates at a lower density, which is especially suitable for the separation of natural substances; the pressure can be adjusted Adjust the dissolving ability of the...

AI Technical Summary

Problems solved by technology

But also find supercritical CO Extraction technology also exists: operating pressure is big, extraction time is long, higher to the requirement of equipment, energy consumption is relatively large, extraction capacity is little, extraction rate is not ideal enough etc. to be improved or improved, and Entrainer is used to strengthen the supercritical extraction process, which can effectively improve the extraction yield and reduce the operating pressure, etc.

[0004] The change law of entrainer property to extraction rate is: the molecular polarity of entrainer is bigger, and the solubility of solute in supercritical CO is bigger; The solubility of the compound is reduced, and the extraction rate is reduced; the entrainer molecules that are easy to form hydrogen bonds can significantly increase the extraction rate; the entrainer with multiple (mixed) components can significantly improve the extraction efficiency, but in the prior art, entrainment is often used Extraction is carried out by directly pumping the agent together with CO2, and because of the fast flow rate of CO2, the entrainer has already flowed away before it can fully contact with the material, resulting in an effective improvement of the extraction performance, which requires a large amount of entrainer, and low extraction efficiency

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