Vespa magnifica peptide WVD-I, and preparation method and applications thereof

A technology of WVD-I and vespa, which is applied in the field of vespa peptide WVD-I and its preparation, and can solve problems such as toxic side effects and the like
CN111116715AInactive Publication Date: 2020-05-08DALI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
DALI UNIV
Publication Date
2020-05-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides vespa magnifica peptide WVD-I, and a preparation method and applications thereof, and belongs to the technical field of biochemical drug preparation. The lyophilized powder of poison gland secretions of vespa magnifica is taken as a raw material; the WVD-I can be obtained through three-step separation of cation exchange high performance liquid chromatography, anion exchangehigh performance liquid chromatography and reversed phase high performance liquid chromatography; and purity can reach more than 98% through mass spectrum identification, and molecular weight is about1,563 Da.
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Description

technical field

[0001] The invention relates to the technical field of preparation of biochemical drugs, in particular to a vespa peptide WVD-I and its preparation method and application. Background technique

[0002] Biotoxins are chemical substances with the highest biological activity and toxicity, and are of great value in exploring the process of life movement and developing new drugs.

[0003] Stroke is an acute cerebrovascular disease, which is a group of diseases that cause brain tissue damage due to sudden rupture of blood vessels in the brain or blockage of blood vessels that prevents blood from flowing into the brain, including ischemic and hemorrhagic strokes. According to the survey, stroke is the leading cause of disability among adults in China. Stroke has the characteristics of high morbidity, high mortality and high disability rate. Most of the drugs currently used to treat stroke are chemical agents, which have problems of toxicity and side effects. Cont...

Claims

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