A strain of Bifidobacterium lactis probio-m8 capable of relieving and improving Alzheimer's symptoms and its application

A bifidobacterium lactis, symptom technology, applied in the direction of bifidobacteria, medical preparations containing active ingredients, applications, etc., can solve the problem of lack of efficient, safe, non-toxic probiotics for Alzheimer's disease, etc.

Active Publication Date: 2022-07-29
BEIJING SCITOP BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Due to the different probiotic effects of probiotic strains, there is currently a lack of probiotics that are highly effective, safe, non-toxic and effective in alleviating Alzheimer's disease

Method used

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  • A strain of Bifidobacterium lactis probio-m8 capable of relieving and improving Alzheimer's symptoms and its application
  • A strain of Bifidobacterium lactis probio-m8 capable of relieving and improving Alzheimer's symptoms and its application

Examples

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experiment example

[0041] Experimental example: Application analysis of Bifidobacterium lactis Probio-M8 in the clinical efficacy observation test in mice

[0042] Experimental method: Taking Bifidobacterium lactis Probio-M8 (Bifidobacterium lactis Probio-M8) as the research object, a 2-month-old male mouse of APP / PS1 transgenic was selected and 3 wild-type female mice of the same age were spontaneously paired to produce . After 30 days, 18 fetuses were born, and all fetuses were genotyped to obtain the number of APP / PS1 mice and wild-type mice. After the mice were normally raised to 4 months of age, 7 mice with APP / PS1 genotype were selected and randomly divided into two groups, one group was intragastrically administered with Bifidobacterium lactis Probio-M8 (4 mice), and the other group was intragastrically administered Physiological saline (3 animals) was administered by gavage for a total of 45 days. After 45 days, the mice were sacrificed, and the mouse brain tissue was removed, fixed ...

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Abstract

The present application discloses a strain of Bifidobacterium lactis Probio-M8 capable of relieving and improving Alzheimer's symptoms and its application. In this application, APP / PS1 mice were used as the experimental objects, and 7 mice with APP / PS1 genotype were selected from the mice produced by paired breeding with wild-type mice, and were randomly divided into two groups. Bifidobacterium Probio-M8, another group was administered with normal saline, and the changes in the number of Aβ plaques in the brain of mice were measured. The experimental results proved that Bifidobacterium lactis Probio-M8 has the effect of relieving and improving Alzheimer's symptoms.

Description

technical field [0001] The present application relates to the field of biotechnology, in particular to a strain of Bifidobacterium lactis capable of relieving and improving Alzheimer's symptoms and its application. Background technique [0002] With the improvement of my country's average life expectancy and the approaching of an aging society, Alzheimer's disease (AD), also known as senile disease, is an ancient but serious threat to the health and social development of the elderly. Dementia, a degenerative disease of the central nervous system, began to appear in the elderly population in my country on a large scale. The main clinical manifestations are neuropsychiatric symptoms such as progressive memory impairment, cognitive dysfunction, personality changes and language disorders, which seriously affect social, occupational and life functions. Different from other senile diseases, the cause of Alzheimer's disease is still unknown and there is no effective treatment drug,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12N1/20A61K35/745A61P25/28A23L33/135A23K10/18A23C9/123C12R1/01
CPCC12N1/20A61K35/745A61P25/28A23L33/135A23K10/18A23C9/1234A23V2002/00C12R2001/01C12N1/205A23V2400/531A23V2200/322
Inventor 刘晓军其木格苏都宋继宏马杰张建军张凌宇姚国强
Owner BEIJING SCITOP BIO TECH CO LTD
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