A modified attapulgite and its preparation method and application in external medicine and skin care products

A technology of attapulgite and topical drugs, which is applied in the direction of drug combinations, cosmetic preparations, cosmetic preparations, etc., to achieve the effects of increasing the load, good slow release, and improving the user experience

Active Publication Date: 2021-01-05
倚康科技(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, attapulgite materials used as auxiliary materials to promote the efficacy of external drugs or skin care products are rarely reported.

Method used

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  • A modified attapulgite and its preparation method and application in external medicine and skin care products
  • A modified attapulgite and its preparation method and application in external medicine and skin care products
  • A modified attapulgite and its preparation method and application in external medicine and skin care products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1. Preparation of modified attapulgite

[0046] To prepare modified attapulgite, follow the steps below:

[0047] 1. Select attapulgite powder with a purity higher than 99.9%, and add an organic solvent (anhydrous ether or petroleum ether or ethyl acetate) to prepare a suspension with a mass concentration of 5%.

[0048] 2. Add attapulgite powder mass 1% to 10% polysaccharide (selected from zymosan, aloe vera leaf polysaccharide, Suizenji laver polysaccharide, sour bean seed polysaccharide, tuberose polysaccharide, euglenophyllum polysaccharide, and Panax angustifolia polysaccharide) One or more of the purplish seed polysaccharides, or any three of them are mixed according to the weight ratio of 1:1:1), and stirred evenly.

[0049] 3. Add 1 / 10,000 concentrated acid (concentrated sulfuric acid or concentrated nitric acid) of attapulgite mass, stir and react at 45°C, and remove the generated water while stirring until no water is formed.

[0050] 4. Filter th...

Embodiment 2

[0064] Example 2. Modified attapulgite is used in skin care products for extracting essence from Chinese herbal medicines

[0065] Material preparation:

[0066] 1. Modified attapulgite, product 1 in Example 1.

[0067] 2. Astragalus water-soluble extract powder: Clean Astragalus membranaceus, slice it, dry it, and ultrafinely pulverize it to 800 meshes, then add ultra-pure water 20 times its mass, stir it with low-temperature ultrasonic for 30 minutes, and use low-temperature and high-pressure differential continuous cell wall The water-soluble essence components are extracted by crushing extraction technology, the aqueous solution is concentrated, freeze-dried, and crushed to 250 meshes to obtain the water-soluble extract powder of Radix Astragali.

[0068] 3. Water-soluble extract powder of angelica sinensis: clean the angelica sinensis, slice it, dry it, and ultrafinely pulverize it to 800 meshes, then add ultra-pure water 20 times its mass, stir ultrasonically at low tem...

experiment example 3

[0078] Experimental Example 3 Product Performance Test

[0079] Products: 6 exemplary products listed in Example 2 and the comparative group products listed in the following table 3-1.

[0080] Table 3-1. Parts by weight of each component in comparative test products and

[0081]

[0082] The experimental design is described as follows:

[0083] Comparing groups 1 and 2, in order to verify the effect of the modified attapulgite: except that the composition of attapulgite is a variable factor, the proportions of the components of the comparison group 1-2 are the same as those of the invention group 1.

[0084] Contrast group 3 is to verify the effect of the process of extracting Astragalus membranaceus and Angelica sinensis of the present invention: the ratio of contrast group 3 and contrast group 1 is the same, but the sources of extracts of Astragalus membranaceus and Angelica sinensis are different.

[0085] Contrast groups 4 and 5 are for comparing the products of the ...

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Abstract

The invention discloses modified attapulgite as well as a preparation method and application thereof in external medicines and skin care products, belongs to the field of new materials, and the modified attapulgite is characterized in that the modified attapulgite is obtained by grafting polysaccharide to the surface of attapulgite, is used for the external medicines or skin care products, and isbeneficial to improving the medicine effect or skin care effect.

Description

technical field [0001] The invention relates to the field of new materials, in particular to a modified attapulgite and its preparation method and application in external medicine and skin care products. Background technique [0002] Attapulgite is a natural clay mineral with a wide range of uses. Due to its excellent smoothness, adhesion and air permeability, it can be suitable for cosmetics such as foundation rouge, powder, eyebrow powder, lipstick, etc. Due to its good compatibility with organisms, it has also been extensively studied as a pharmaceutical carrier, especially as a targeted drug carrier and drug sustained-release agent. However, attapulgite materials used as auxiliary materials to promote the efficacy of external drugs or skin care products are rarely reported. [0003] Natural products such as astragalus, angelica, and aloe vera gel can be used as raw materials for cosmetics, and have functions such as anti-aging, whitening, moisturizing, and repairing. S...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/26A61K8/73A61K8/9789A61K31/715A61K33/12A61K47/52A61K47/55A61P17/00A61P31/04A61Q17/00A61Q19/00A61Q19/02A61Q19/08
CPCA61K8/26A61K8/73A61K31/715A61K33/12A61Q17/005A61Q19/00A61Q19/02A61Q19/08A61K8/9789A61K47/52A61K47/55A61P17/00A61P31/04A61K2300/00
Inventor 张哲王丹阳薛圣鸽王玉兰刘扬
Owner 倚康科技(深圳)有限公司
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