Spectinomycin hydrochloride soluble powder capable of being directly dissolved in oil seedlings and preparation method thereof

A guanlincomycin and soluble technology, which is applied in medical preparations with non-active ingredients, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of low bioavailability, high cost of use, poor dissolution effect, etc. problem, to achieve the effect of improving potency, reducing use cost and simplifying operation

Active Publication Date: 2020-06-19
山东迅达康兽药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of lincomycin hydrochloride soluble powder directly soluble in oil seedlings and its preparation method, which solves the problem of being soluble in oil seedling diluent, poor dissolving effect, low uniformity, and bioavailability in the prior art. Low efficiency and high cost of use

Method used

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  • Spectinomycin hydrochloride soluble powder capable of being directly dissolved in oil seedlings and preparation method thereof
  • Spectinomycin hydrochloride soluble powder capable of being directly dissolved in oil seedlings and preparation method thereof
  • Spectinomycin hydrochloride soluble powder capable of being directly dissolved in oil seedlings and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023]

[0024] Preparation:

[0025] Mix sodium lauryl sulfate and sodium stearate with anhydrous glucose according to the formula ratio, crush them and pass through a No. 5 sieve, weigh them for later use; mix cholesterol, lecithin and cocoa butter according to the formula ratio, fully After grinding, pass through a No. 5 sieve, and weigh for later use; weigh spectinomycin hydrochloride, lincomycin hydrochloride, and astragalus polysaccharide, and crushed and sieved sodium lauryl sulfate, sodium stearate, anhydrous glucose and ground, The sieved cholesterol, lecithin and cocoa butter are uniformly mixed by a three-dimensional mixer to obtain the product.

Embodiment 2

[0027]

[0028]

[0029] Preparation:

[0030] Mix Poloxamer 188, sodium stearate and anhydrous glucose according to the formula ratio, crush them and pass through a No. 5 sieve, and weigh them for later use; mix cholesterol, lanolin and cocoa butter After grinding, pass through a No. 5 sieve, and weigh for later use; weigh spectinomycin hydrochloride, lincomycin hydrochloride, soybean polysaccharide, and crushed and sieved Poloxamer 188, sodium stearate, anhydrous glucose and ground , and the sieved cholesterol, lanolin and cocoa butter are evenly mixed by a three-dimensional mixer to obtain the product.

Embodiment 3

[0032]

[0033] Preparation:

[0034] Mix sodium stearate with anhydrous glucose according to the formula ratio, crush it and pass it through a No. 5 sieve, and weigh it for later use; mix cholesterol, lecithin and cocoa butter according to the formula ratio, grind it in a mortar and pass it through a No. 5 sieve , weighed for later use; Weigh spectinomycin hydrochloride, lincomycin hydrochloride, soybean polysaccharide, astragalus polysaccharide, and crushed and sieved sodium stearate and anhydrous glucose as well as ground and sieved cholesterol, egg Phospholipids and cocoa butter are uniformly mixed by a three-dimensional mixer to obtain the product.

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Abstract

The invention discloses a spectinomycin hydrochloride soluble powder capable of being directly dissolved in oil seedlings, and belongs to the technical field of veterinary drug preparations. The spectinomycin hydrochloride soluble powder capable of being directly dissolved in oil seedlings comprises 40 parts of spectinomycin hydrochloride, 20 parts of lincomycin hydrochloride, 3-6 parts of an oil / water emulsifier, 7-10 parts of a water / oil emulsifier, 2-4 parts of immune polysaccharides and 20-28 parts of auxiliary materials. The soluble powder can be directly and uniformly dissolved in oil seedlings without any oil seedling dilution liquid, and solves the problems of need of dissolving in the oil seedling dilution liquid, poor dissolving effect, low uniformity, low bioavailability and high use cost in the prior art. The spectinomycin hydrochloride soluble powder facilitates the clinic breeding operation and application on the basis of guaranteeing the quality and the curative effect of the above product, and reduces the use cost.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a lincomycin hydrochloride soluble powder directly soluble in oil seedlings and a preparation method thereof. Background technique [0002] Lincomycin (lincomycin) is a lincosamide antibiotic, which has a strong antibacterial effect on most anaerobic bacteria and Gram-positive bacteria. Spectinomycin is an aminoglycoside antibiotic that has specific inhibitory effects on Gram-positive bacteria, negative bacteria and mycoplasma. The combination of lincomycin hydrochloride and spectinomycin hydrochloride has a synergistic effect, a wide antibacterial spectrum, rapid action, and small toxic and side effects. The therapeutic dose has no adverse effects on chickens, pigs and other farmed animals. It is effective against chicken chronic respiratory diseases caused by mycoplasma. Both diarrhea and enteritis caused by Escherichia coli and Escherichia col...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K47/44A61K47/36A61K47/10A61K47/20A61K47/12A61K47/28A61K47/24A61K31/7056A61K31/357A61K31/715A61P31/04
CPCA61K9/148A61K9/146A61K9/145A61K31/7056A61K31/357A61K31/715A61P31/04A61K2300/00
Inventor 汪安国田玉虎李凤华李梁梁
Owner 山东迅达康兽药有限公司
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