124 results about "Lincomycine" patented technology

The invention relates to a test strip for rapidly detecting residues and a preparation method of the test strip. The bottom layer of the test strip is used as a supporting layer; an intermediate adsorption layer is fixed on the supporting layer; an external protection layer is fixed on the adsorption layer; the adsorption layer comprises an adsorption fiber layer, a gold-labeled antibody fiber layer for adsorbing and coupling lincomycin and a cellulose membrane layer sequentially arranged on the testing sample end and further comprises a water absorbing material layer arranged on the handle end; a detection blot printed by a lincomycin carried protein solution and a control blot printed by a goat anti- or rabbit anti-mouse IgG antibody solution are arranged on the cellulose membrane layer. The test strip is high in detection specificity, high in sensitivity and simple and fast in operation; detection results are displayed visually, directly and accurately; a special apparatus and a professional are not in need in the detection; and the test strip has the following characteristics of low cost, low investment as well as easiness for promotion and application.

The invention provides an extraction method of lincomycin. The extraction method mainly comprises the following steps: adjusting acidity of fermentation liquor, filtering by using a ceramic ultrafiltration membrane, then adjusting alkalinity, then filtering by using a ceramic ultrafiltration membrane again, then carrying out primary sec-octyl alcohol extraction and hydrochloric acid back-extraction, adjusting alkalinity of the primary back extraction liquor and then filtering by using a ceramic ultrafiltration membrane again; carrying out secondary sec-octyl alcohol extraction and hydrochloric acid back-extraction and adding acetone to the secondary back extraction liquor to carry out evaporative crystallization. According to the extraction method provided by the invention, the yield of the lincomycin is high, the color grade of the lincomycin can be improved, and the B component content in the lincomycin is reduced. According to the extraction method of the lincomycin, the feed liquid quality of other extraction technologies can be improved by a membrane treatment process, the integral extraction efficiency is further improved, the residual volume of sec-octyl in raffinate in the extraction procedure is reduced, the product quality is improved, and meanwhile, the COD (Chemical Oxygen Demand) in produced wastewater is reduced. The extraction method has certain economic benefit and environmental benefit.

This invention provides compounds of formula (I) or its pharmacologically acceptable salt or solvate, wherein A represents aryl or a monocyclic or bicyclic heterocyclic group, R1 represents a halide, nitro, substituted C1-6 alkyl, optionally substituted amino, C1-6 alkyloxycarbonyl, optionally substituted aryl, a heterocyclic group, or heterocyclic carbonyl, R2 represents a hydrogen atom or C1-6 alkyl, R3 represents C1-6 alkyl, all of R4, R5, and R6 represent a hydrogen atom, R7 represents C1-6 alkyl, m is 1 or 2, and n is 1. The compounds are novel lincomycin derivatives having a potent activity against resistant pneumococci. The compounds can be used as an antimicrobial agent and are useful for preventing or treating bacterial infectious diseases.