Compound preparation for reducing hepatotoxicity of tripterygium glycoside tablets, and preparation method of compound preparation

A technology of tripterygium glycosides and compound preparations, which is applied in the field of medicine, can solve the problems of complicated process and reduced nephrotoxicity, and achieve the effects of simple preparation process, increased dosage, and improved curative effect

Inactive Publication Date: 2020-06-19
HUNAN QIANJIN XIELI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent provides a new preparation method of tripterygium glycosides, the process is relatively complicated, and the obtained tripterygium glycosides has reduced nephrotoxicity, and does not involve research on the reduction of tripterygium glycosides liver toxicity

Method used

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  • Compound preparation for reducing hepatotoxicity of tripterygium glycoside tablets, and preparation method of compound preparation
  • Compound preparation for reducing hepatotoxicity of tripterygium glycoside tablets, and preparation method of compound preparation
  • Compound preparation for reducing hepatotoxicity of tripterygium glycoside tablets, and preparation method of compound preparation

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Experimental program
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Effect test

Embodiment 1

[0043] Preparation of compound preparation for reducing hepatotoxicity of Tripterygium wilfordii polyglycoside tablets according to the present invention

[0044] 1. Prescription composition

[0045]

[0046] 2. Preparation method

[0047](1) Preparation of silybin meglumine immediate-release tablets

[0048] Weigh the auxiliary materials according to the prescription quantity; put the auxiliary materials into the high-efficiency mixing granulator and mix for 3 minutes, add an appropriate amount of purified water to make granules; send the granules into the boiling granulator, and dry them at 90°C for about 20 minutes; For good blank granules, put the original powder into a high-efficiency mixing granulator and mix for 3 minutes, add an appropriate amount of medicinal anhydrous ethanol at a uniform speed to granulate; granulate, and sieve with an 18-mesh sieve to make the particle size appropriate and the thickness ratio appropriate; After the granules are prepared, add m...

Embodiment 2

[0054] Preparation of compound preparation for reducing hepatotoxicity of Tripterygium wilfordii polyglycoside tablets according to the present invention

[0055] 1. Prescription composition

[0056]

[0057] 2. Preparation method

[0058] (1) Preparation of silybin meglumine immediate-release tablets

[0059] With embodiment 1.

[0060] (2) Preparation of tripterygium glycosides sustained-release tablet

[0061] With embodiment 1.

[0062] (3) Tablet

[0063] The prepared silybin meglumine immediate-release tablets and tripterygium polyglycoside sustained-release tablets are compressed into tablets; the tablet press speed is set to 25 rpm, and the tablet compression pressure is 8KN; the prepared double-layer tablet Freeze-dry at 60°C for 180 minutes, and freeze for 90 minutes; pack and store.

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Abstract

The invention discloses a compound preparation for reducing hepatotoxicity of tripterygium glycoside tablets, and a preparation method of the compound preparation. The compound preparation comprises silibin meglumine tablets and the tripterygium glycoside tablets. The compound preparation has the efficacies of protecting the liver for detoxification, tonifying the kidney and strengthening the spleen; the dosage of tripterygium glycosides can be obviously increased; a better curative effect is achieved; and meanwhile, the hepatotoxicity of the tripterygium glycosides is obviously reduced. In addition, according to the compound preparation, the fast release of silibin meglumine and the long-acting stable release of tripterygium glycosides can be realized, and the treatment effect is furtherimproved. In addition, the preparation method provided by the invention has the advantages that the operation is simple; the cost is low; the preparation method is suitable for industrial production;and the application prospects are good.

Description

technical field [0001] The invention belongs to the technical field of medicine. More specifically, it relates to a compound preparation for reducing hepatotoxicity of Tripterygium wilfordii polyglycoside tablets and a preparation method thereof. Background technique [0002] Tripterygium wilfordii Hook.f. is a woody vine of the genus Tripterygium wilfordii in the Euonymus family. It is bitter in nature and has a strong poison. Tripterygium wilfordii polyglycoside is the main active part of Tripterygium wilfordii, which has anti-inflammatory, analgesic, anti-tumor and immune regulation effects, and is often used clinically to treat skin inflammation, immunosuppression, and malignant tumors. [0003] However, Tripterygium wilfordii polyglycosides have obvious toxic reactions, especially in large doses, which can cause great damage to the heart, liver, kidney, hematopoietic system, and gastrointestinal tract. Its main active ingredient is also the main toxic ingredient, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/357A61K36/37A61P37/06A61P29/00A61P35/00
CPCA61K9/2054A61K9/2059A61K9/209A61K31/357A61K36/37A61P29/00A61P35/00A61P37/06A61K2300/00
Inventor 刘如斯邹洋张元宵周超任超廖爱玲
Owner HUNAN QIANJIN XIELI PHARMA CO LTD
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