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Intelligent composite material for controlled drug releasing and monitoring

A composite material and intelligent technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of not being able to easily observe the degree of drug release, and achieve simplified release and monitoring process, The effect of simple operation and low cost

Inactive Publication Date: 2020-06-23
HUNAN UNIV
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  • Description
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  • Application Information

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Problems solved by technology

[0004] In view of this, the present invention aims to propose a smart composite material for drug controllable release and monitoring, to develop a smart composite material with drug loading and controllable release functions and capable of real-time monitoring of drug release, to solve the problem of Traditional materials with drug loading and release functions cannot easily observe the demand for drug release

Method used

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  • Intelligent composite material for controlled drug releasing and monitoring
  • Intelligent composite material for controlled drug releasing and monitoring
  • Intelligent composite material for controlled drug releasing and monitoring

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Embodiment Construction

[0025] The present invention will be described in detail below in conjunction with accompanying drawing and specific embodiment

[0026] An intelligent composite material for controlled drug release and monitoring, the preparation of the intelligent composite material comprises the following steps:

[0027] (1) The preparation steps of soft poly N-isopropylacrylamide-acrylic acid particles are as follows:

[0028] 100ml of ultrapure water was added to a 250mL three-neck round bottom flask, followed by adding N-isopropylacrylamide with a mass content of 89.99%, 2% methylenebisacrylamide, 0.01% acrylic acid and 8% dodecyl Sodium Alkyl Sulfate, the mixture was purged with nitrogen for 30 min during mechanical stirring. When the mixture was heated to 72° C., an aqueous solution of potassium persulfate with a mass fraction of 4% was added thereto, and the mixture was continuously heated and stirred for 6 h. The obtained product was packed with a dialysis bag and a sealing clip, p...

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Abstract

The invention provides an intelligent composite material for controlled drug releasing and monitoring. The synthesis of the material includes the preparation of soft poly N-isopropyl-isopropyl acrylamide-acrylic acid particles, the preparation of a soft ball crystal array and a microgel colloid array membrane, an experiment of microgel colloid array membrane loaded with bovine serum albumin, and the application of the prepared intelligent composite material for the controlled releasing and monitoring of bovine serum albumin. The prepared intelligent composite material utilizes the temperaturesensitivity of soft balls to control the releasing of drugs and is self-assembled with the abilities of an ordered structure, so that the controlled releasing and monitoring of the drugs can be achieved through the change of structural colors or the change of diffraction peaks, the disadvantages that traditional drug monitoring methods need to be based on instrument operation and processes are complex can be successfully solved, the requirements for the controlled releasing and real-time monitoring of the drugs can be realized, and the demands in actual application for simple and easy operation on drug monitoring can be met.

Description

technical field [0001] The invention belongs to the technical field of photonic crystals, and in particular relates to an intelligent composite material which is simultaneously used for controlled drug release and monitoring. Background technique [0002] Moving nanomedicine from laboratory development to clinical use requires biocompatible, nontoxic matrices for drug delivery. Nanoparticles commonly found in drug carriers, such as quantum dots and carbon nanotubes, can be toxic to humans. Moreover, there are defects such as poor water solubility, poor stability, and poor selectivity during the delivery of drug molecules. It is urgent to find a carrier capable of controlled release of drugs to effectively solve these problems. [0003] Due to their good biocompatibility and faster response to external stimuli (pH, temperature, etc.) than hydrogels, microgels have been widely used as biosensing materials and drug delivery vehicles. Based on its thermosensitivity, poly-N-is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/32A61K38/38C08F220/54C08F220/06C08F222/38
CPCA61K47/32A61K38/385C08F220/54C08F220/06C08F222/385
Inventor 吴朝阳李丽刘文钊
Owner HUNAN UNIV
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