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Hollow capsule enteric coated sealing ring composition and preparation method and application thereof

A technology of hollow capsules and compositions, which is applied in the fields of capsule delivery, non-active ingredients of polymer compounds, pharmaceutical formulations, etc., to achieve the effects of mechanical properties, anti-collision, firm adhesion, and good effects

Inactive Publication Date: 2020-06-30
BRIGHT FUTURE PHARMA LAB LTD (CN) +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, liquids, suspensions, pastes and other contents that need enteric release on the market can only use soft capsules and other dosage forms

Method used

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  • Hollow capsule enteric coated sealing ring composition and preparation method and application thereof
  • Hollow capsule enteric coated sealing ring composition and preparation method and application thereof
  • Hollow capsule enteric coated sealing ring composition and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The empty capsules in the embodiment are gelatin enteric-coated empty capsules, and the model is 0#. The content is standard myrtle oil, and the filling volume is 400mg.

[0042] The components of the ring-sealing composition are as follows: 23wt% gelatin, 15wt% methacrylic acid copolymer, 1wt% glycerin, and 61% water.

[0043]Weigh 23 parts by mass of gelatin, 44 parts by mass of water, and 1 part by mass of glycerin in proportion, put them into the cooking liquid tank, turn on the heating to 65°C, stir at a speed of 60r / min for 40min, and record it as liquid A. Take 17 parts by mass of water and 15 parts by mass of methacrylic resin at room temperature, stir at a speed of 40 r / min for 20 min, and record it as liquid B. Mix the AB and AB solutions that have been stirred enough, and use an emulsifier to stir at a speed of 600 r / min for 15 minutes at 50°C. Let the emulsified liquid stand still to obtain the enteric-coated ring-sealing solution, which is stored at a con...

Embodiment 2

[0048] In the embodiment, the hollow capsule is selected from hydroxypropyl methylcellulose enteric-coated hollow capsule, and the model is 1#. The content is fish oil, and the loading capacity is 300mg.

[0049] The components of the ring sealing composition are as follows: 14wt% of hydroxypropyl methylcellulose, 11.5wt% of hydroxypropylmethylcellulose phthalate, 2wt% of propylene glycol, 65wt% of water, 7wt% of ethanol, soybean lecithin 0.5wt%,.

[0050] Weigh 14 parts by mass of hydroxypropyl methylcellulose, 62 parts by mass of water, 0.5 parts by mass of soybean lecithin, and 2 parts by mass of propylene glycol in proportion, put them into the boiling liquid tank, turn on the heating to 65°C, / min speed stirring for 40min, recorded as A solution. Take 7 parts by mass of ethanol, 3 parts by mass of water, and 11.5 parts by mass of hydroxypropylmethylcellulose phthalate at room temperature, stir at a speed of 40 r / min for 20 minutes, and record it as liquid B. Mix the tw...

Embodiment 3

[0055] The hollow capsules in the embodiment are pullulan enteric-coated hollow capsules, the type of which is 2#. The content is garlic essential oil, with a loading capacity of 200mg.

[0056] The components of the ring sealing composition are as follows: gelatin 13wt%, methacrylic acid copolymer 8wt%, pectin 2wt%, sorbitol 1.5wt%, water 64.5wt%, ethanol 5.5wt%, 5wt% Tween 80, 0.5wt% % Simethicone.

[0057] Weigh 13 parts by mass of gelatin, 52.5 parts by mass of water, 1.5 parts by mass of sorbitol, 5 parts by mass of Tween 80, and simethicone oil of 0.5 parts by mass, put them into the boiling liquid tank, turn on and heat until Stir at 60°C for 40min at a speed of 60r / min, and record it as liquid A. Take 12 parts by mass of water, 5.5 parts by mass of ethanol, 8 parts by mass of methacrylic acid copolymer, and 2 parts by mass of pectin at 70°C, stir at a speed of 40 r / min for 20 minutes, and record it as liquid B. Mix the AB and AB solutions that have been stirred enou...

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Abstract

The invention relates to a hollow capsule enteric coated sealing ring composition and a preparation method and application thereof. The hollow capsule enteric coated sealing ring composition comprisesthe following components by mass of 10-23wt% of a gelling agent, 5-15wt% of a dispersing agent, 1-4wt% of a plastifier and the balance solvents, wherein the gelling agent is gelatin, hydroxypropyl methyl cellulose or combination of the gelatin and the hydroxypropyl methyl cellulose. For sealing ring capsules prepared by ring sealing with the sealing ring composition, each sealing ring and the corresponding capsule body are firmly adhered, and are indissolvable in the stomach, resolvable in the intestine, good in sealing property, excellent in mechanical properties, and good in properties of preventing collision, and separating oxygen and moisture.

Description

technical field [0001] The invention belongs to the technical field of hollow capsule ring sealing, and relates to a hollow capsule enteric ring sealing composition, a preparation method and application thereof. Background technique [0002] The contents of the capsule are in the form of fine powder, granules, pellets, liquid, suspension, paste, etc. The capsule shell refers to the capsule used to wrap the content, which is divided into hollow capsules and soft capsules. It can be divided into two kinds of vegetable capsule shells and gelatin capsule shells. Gelatin, vegetable gum (hydroxypropyl methylcellulose, pullulan shell) empty capsules are made of gelatin, vegetable gum (hydroxypropyl methylcellulose, pullulan) firstly add plasticizer, Preservatives, pigments and other auxiliary materials are soaked and boiled, and after vacuum degassing, they are obtained by dipping in glue, drying, shelling, cutting and other processes on a capsule machine. Enteric-coated gelatin,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K47/42A61K47/32A61K47/10A61K47/38A61K47/24A61K47/36A61K47/26A61K47/34A61K47/20
CPCA61K9/4816A61K9/4825
Inventor 马鸿鑫贾岳陆晓峰王晨曦蒋晓燕占豪孔娜
Owner BRIGHT FUTURE PHARMA LAB LTD (CN)
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