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Method for preparing wash-free alcohol-silk protein gel disinfectant

A silk protein and disinfectant technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of complex ingredients and poor skin care effect, and achieve the effects of enhancing sterilization effect, delaying volatilization, and using safety.

Inactive Publication Date: 2020-07-03
HANGZHOU WENSLI SILK CULTURE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Another example is that the publication date is January 04, 2017, and the Chinese patent with the publication number CN106265436A discloses a formula and preparation method of a disposable disinfectant with skin care effect. The disposable disinfectant consists of a thickener, a disinfectant agent, solubilizer, inclusion agent, neutralizer, moisturizer, skin care agent, essence and deionized water, the composition is complex and the skin care effect is poor

Method used

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  • Method for preparing wash-free alcohol-silk protein gel disinfectant

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Experimental program
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Effect test

Embodiment 1

[0026] The preparation method of alcohol-silk protein gel disposable disinfectant in the present embodiment is as follows.

[0027] Cocoon shells were treated with 0.5% (w / v) Na 2 CO 2 Degumming, bath ratio 1:200, 30min each time, wash with water after degumming, repeat once, obtain silk fibroin fiber after drying. With 50% (w / v) CaCl 2 Aqueous solution dissolves silk fiber, dissolving temperature is 98 ℃, liquor ratio (silk fiber g: CaCl 2 The aqueous solution ml) is 1:25, and the time is 10 minutes. Pour the solution obtained after dissolving into a dialysis bag (molecular weight cut-off 12000-14000), dialyze in running water for 3 days, and dilute with water to obtain a silk fibroin solution with a concentration of 1% (w / v).

[0028] Add 50ml of silk fibroin solution with a concentration of 1% (w / v) in the container, then quickly add 1L of medical alcohol with a volume percentage concentration of 75%, stir immediately for 0.5 minutes, and the stirring speed is 150 rpm t...

Embodiment 2

[0030] The preparation method of alcohol-silk protein gel disposable disinfectant in the present embodiment is as follows.

[0031] Cocoon shells were treated with 0.5% (w / v) Na 2 CO 2 Degumming, bath ratio 1:200, 30min each time, wash with water after degumming, repeat once, obtain silk fibroin fiber after drying. Dissolve silk fibroin fiber with ternary solvent, the ratio of ternary solvent [n(Ca_Cl 2 ): n(H 2 O):n(C 2 h 5 OH)=1:8:2], bath ratio (silk fibroin g: ternary solution ml)=1:15, dissolution temperature 80°C, time 10 minutes. The solution obtained after dissolving was poured into a dialysis bag (molecular weight cut-off 12000-14000), dialyzed in running water for 3 days, air-dried and concentrated to obtain a 5% (w / v) silk fibroin solution.

[0032]For the preparation method of small molecule sericin solution, please refer to the patent application number 201810298137.8, the patent name is "a preparation method of water-soluble silk fibroin and sericin composi...

Embodiment 3

[0035] The preparation method of alcohol-silk protein gel disposable disinfectant in the present embodiment is as follows.

[0036] Cocoon shells were treated with 0.5% (w / v) Na 2 CO 2 Degumming, bath ratio 1:200, 30min each time, wash with water after degumming, repeat once, obtain silk fibroin fiber after drying. Dissolve silk fibroin fiber with ternary solvent, the ratio of ternary solvent [n(Ca_Cl 2 ): n(H 2 O):n(C 2 h 5 OH)=1:8:2], bath ratio (silk fibroin g: ternary solution ml=1:15), dissolution temperature 80°C, time 10 minutes. The solution obtained after dissolving was poured into a dialysis bag (molecular weight cut-off 12000-14000), dialyzed in running water for 3 days, air-dried and concentrated to obtain 8% (w / v) silk fibroin solution.

[0037] For the preparation method of small molecule sericin solution, please refer to the patent application number 201810298137.8, the patent name is "a preparation method of water-soluble silk fibroin and sericin composit...

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Abstract

The invention relates to a method for preparing a wash-free alcohol-silk protein gel disinfectant. Currently, no wash-free disinfectant which is safe in use and convenient to apply to hands and can moisturize skin has been provided. The preparation method is characterized by comprising the following step of mixing 100ml of a medical alcohol solution, 5-10ml of a silk fibroin solution and 0-2ml ofa small molecule sericin protein solution evenly to prepare a wash-free alcohol-silk protein gel disinfectant, wherein the operation mode of mixing the solutions evenly comprises the steps of firstlyadding the silk fibroin solution into a container, then slowly adding the small molecule sericin protein solution, stirring the solutions for 2-3 minutes, quickly adding the medical alcohol solution and stirring and mixing the solutions for 20 seconds to 1 minute to complete mixing. The wash-free alcohol-silk protein gel disinfectant prepared by the method is safe for a human body and convenient to use and can moisturize the skin.

Description

technical field [0001] The invention relates to a preparation method of a hand-use disposable disinfectant, in particular to a preparation method of an alcohol-silk protein gel disposable disinfectant. Background technique [0002] Hands are usually the part where people come into contact with the most bacteria and viruses daily. Bacteria and viruses can easily enter the body through the food that hands touch or rub the face with hands and cause infection. And then infect others. Therefore, washing your hands frequently is necessary to keep your hands clean, especially before meals and when you go home. [0003] Wash your hands with hand sanitizer first, then rinse with water. But when there is no water around, spraying hand sanitizer is also a way. The relatively safe disposable disinfectant with good sterilization effect has alcohol with a concentration of about 75%, but this type of alcohol also has disadvantages, that is, it is irritating to the skin, and the skin on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/34A61K8/04A61Q17/00A61Q19/00A61Q19/10
CPCA61K8/64A61K8/34A61K8/042A61Q19/10A61Q17/005A61Q19/00
Inventor 李建华屠红燕娄永强包强余志伟闵思佳
Owner HANGZHOU WENSLI SILK CULTURE
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