System and method for establishing mouse model of diastolic heart failure (DHF) and cardiac resynchronization therapy (CRT)

Abstract

The invention relates to a system and method for establishing a mouse model of diastolic heart failure (DHF) and cardiac resynchronization therapy (CRT), and belongs to the technical field of cardiovascular disease animal models. The system comprises a pace-making system and an electrocardiograph (ECG) record system, wherein one end of a pace-making lead of the pace-making system is connected withmyocardium of a mouse, and the other end of the pace-making lead is connected with a pulse generator through a row needle terminal; and one end of an ECG lead of the ECG record system is connected with pectoralis major muscle of the mouse, and the other end of the ECG lead is connected with an ECG through a row needle terminal. The system can quickly realize heart pace-making through the exogenous pulse generator and the metal pace-making lead to realize DHF and CRT and is connected with the heart and the exogenous pulse generator through the metal ECG lead to record ECG activity. The established mouse model of the DHF and CRT can be applied to basic research about the DHF and CRT later. The system is simple in composition and structure, convenient to produce and lower in manufacturing cost.

Description

technical field [0001] The invention relates to a system and method for establishing a mouse model of cardiac asynchrony and resynchronization, and belongs to the technical field of cardiovascular disease animal models. Background technique [0002] Currently, there are two ways to establish a mouse model of desynchronized heart failure (DHF) and cardiac resynchronization (CRT) through rapid pacing. One is to use a leadless pacemaker from Medtronic, Inc. Micra, a leadless pacemaker, was implanted subcutaneously in the back of the mouse for about 4 weeks of ventricular pacing after adjustment. However, as the latest device, Micra is currently very expensive and is not practical for routine application; The advantage of the pacing system with resonance coupling technology is that it does not require a battery, but the experimental cost is very high due to the need to establish a magnetic field conversion, and this system cannot perform ECG monitoring and recording. Obviously,...

AI Technical Summary

Problems solved by technology

[0002] Currently, there are two ways to establish a mouse model of desynchronized heart failure (DHF) and cardiac resynchronization (CRT) through rapid pacing. One is to use a leadless pacemaker from Medtronic, Inc. Micra, a leadless pacemaker, was implanted subcutaneously in the back of the mouse for about 4 weeks of ventricular pacing after adjustment. However, as the latest device, Micra is currently very expensive and is not practical for routine application; The advantage of the resonant coupling technology pacing system is that it does not require a battery, but due to the need to establish a magnetic field conversion, the experimental cost is very high, and this system cannot perform ECG monitoring and recording

Obviously, the methods provided by these latest studies still cannot meet the actual experimental needs of medicine, especially when the scientific research and design foundation of domestic implantable cardiac pacemakers is still relatively weak.

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