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A kind of assay method of pet imaging agent precursor fcpha and its cis-isomer

A PET imaging agent, cis isomer technology, applied in the field of analytical chemistry, to achieve good chiral recognition ability, improved signal-to-noise ratio, and good resolution.

Active Publication Date: 2021-08-10
BEIJING SINOTAU INT PHARMA TECH CO LTD
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  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the technical problem that there is no method for separating and detecting the cis-trans three-membered ring isomers of saturated fatty acids in the prior art, and to provide a method for the determination of PET imaging agent precursor FCPHA and its cis-isomers

Method used

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  • A kind of assay method of pet imaging agent precursor fcpha and its cis-isomer
  • A kind of assay method of pet imaging agent precursor fcpha and its cis-isomer
  • A kind of assay method of pet imaging agent precursor fcpha and its cis-isomer

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Embodiment 1

[0033] 1. Experimental materials

[0034] Biphenyl derivative chiral chromatography column (equipped with binary gradient pump, autosampler and CAD detector);

[0035] The purity of FCPHA and cis-FCPHA is not less than 95%;

[0036] Acetonitrile and purified water were chromatographically pure, and formic acid was purchased from Fisher;

[0037] The preparation method of biphenyl derivative chiral chromatography column:

[0038]1) Soak the silica gel with 6mol / L hydrochloric acid to activate it, wash it with deionized water until it is neutral, and then dry it in a vacuum oven to obtain activated silica gel; weigh 6g of the activated silica gel, and dry it under reduced pressure at 180°C until there is no moisture , then add 1mL triethylamine, 50mL toluene and 1.8mL 3-aminopropyltriethoxysilane to it, place in a 100mL round-bottomed flask, reflux at 80°C for 16h, and use n-hexane, diethyl ether, and no Washing with water and ethanol in sequence until there is no triethylami...

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Abstract

The invention discloses a method for determining PET imaging agent precursor FCPHA and its cis-isomer. The assay method adopts a biphenyl derivative chiral chromatographic column, the mixed solvent is the mobile phase, and the CAD electrospray detector detects the chromatographic signal, and compares the chromatograms of the test sample solution and the reference substance solution to determine the cis-form in the test sample. Isomer content. The biphenyl derivative chiral chromatographic column prepared by the present invention has better chiral recognition ability, and it is applied to the determination of PET imaging agent precursor FCPHA and its cis-isomers, which cannot be achieved by conventional chromatographic columns. With good resolution and excellent peak shape, and improved signal-to-noise ratio, FCPHA and its three-membered ring cis-isomer can be separated simply, quickly and accurately, with excellent separation effect, low cost of separation and detection, and effective control of front The quality of the body FCPHA.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, and in particular relates to a method for determining a PET imaging agent precursor FCPHA and its cis-isomer. Background technique [0002] According to the data provided by the recent research report of the Chinese Center for Disease Control and Prevention, the proportion of coronary heart disease deaths in the Chinese population increased from 8.6% in 1990 to 15.2% in 2013; The proportion of Chinese nationals increased from 29% to 37%. The study estimated that the total number of deaths from coronary heart disease in China in 2013 was 1.394 million, a 90% increase from the number of deaths from coronary heart disease in 1990. At present, coronary heart disease has become the first cause of death in six provinces, municipalities / provincial administrative regions of my country. A number of research results have shown that with the intensification of the aging process, the incidence and death...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/60
CPCG01N30/02G01N30/06G01N30/60
Inventor 徐新盛沈燕
Owner BEIJING SINOTAU INT PHARMA TECH CO LTD
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