Electrochemical detection method for multiple types of harmful elements in traditional Chinese medicinal materials and preparations thereof

A technology of harmful elements and Chinese herbal medicines, which is applied in the field of electrochemical detection of multiple types of harmful elements in Chinese herbal medicines and their preparations, can solve problems such as the inability to realize rapid detection of multiple types of harmful elements, and achieve the effect of increasing efficiency and simplifying the test system

Inactive Publication Date: 2020-08-07
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0006] Aiming at the problem that the complex matrix of Chinese herbal medicines and their preparations seriously interferes with the accuracy and sensitivity of the detection of harmful elements, and the rapid detection of multiple types of harmful elements cannot be realized, the present invention proposes an electrochemical detection method for multiple types of harmful elements in Chinese herbal medicines and their preparations , through the removal of materials and / or electrodeposition adsorption and removal of interfering components in the test system in the pretreatment to purify the complex matrix and obtain a stable baseline. Combined and rapid detection of multiple types of harmful elements in complex interfering matrices

Method used

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  • Electrochemical detection method for multiple types of harmful elements in traditional Chinese medicinal materials and preparations thereof
  • Electrochemical detection method for multiple types of harmful elements in traditional Chinese medicinal materials and preparations thereof
  • Electrochemical detection method for multiple types of harmful elements in traditional Chinese medicinal materials and preparations thereof

Examples

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Effect test

Embodiment 1

[0045] Embodiment 1: the embodiment of the combined detection of Pb, Cd and Cu in Xiaochaihu decoction

[0046] The compound preparation Xiaochaihu decoction was selected as the solution to be tested, and the nanobismuth metal electrode and square wave stripping voltammetry were used to monitor the content of multiple types of harmful elements in the matrix of traditional Chinese medicine in real time. The chemical detection method, the specific steps are as follows:

[0047] Step 1: Pretreatment of the solution to be tested:

[0048] 1.1. Matrix purification: select hydroxyapatite and biomimetic materials for matrix pretreatment, until a relatively stable electrochemical test matrix baseline is obtained. Among them, the material use conditions are as follows: solution stirring speed: 200rpm, reaction temperature: 25-35°C, use 1-5g to remove material per 100mL decoction, reaction time: 10min, use centrifuge to separate water after matrix purification reaction Decoction and r...

Embodiment 2

[0056] Embodiment 2: the embodiment of the combined detection of Hg and Cu in the kelp digestion solution

[0057] The marine drug kelp digestion solution was selected as the solution to be tested, and the nano-gold electrode and square wave stripping voltammetry were used to monitor the content of multiple types of harmful elements in the matrix of traditional Chinese medicine in real time. An electrochemical detection method for multiple types of harmful elements in the kelp digestion solution, specifically Proceed as follows:

[0058] Step 1: Pretreatment of the solution to be tested:

[0059] 1.1 Matrix purification: Electrodeposition is used for matrix purification pretreatment until a relatively stable electrochemical test matrix baseline is obtained, and electrochemical test solution / purified matrix solution is obtained. The electrochemical purification conditions are as follows: use NaAc saturated solution to adjust pH: 4.7, stirring speed 50rpm, reaction temperature:...

Embodiment 3

[0067] Embodiment 3: The embodiment of the combined detection of As, Cu and Hg by the silkworm digestion solution

[0068] The animal drug Bombyx worm digestion solution was selected as the solution to be tested, and the nano-gold electrode and square wave stripping voltammetry were used to monitor the content of multiple types of harmful elements in the matrix of traditional Chinese medicine in real time, an electrochemical detection method for multiple types of harmful elements in the Bombyx worm digestion solution ,Specific steps are as follows:

[0069] Step 1: Pretreatment of the solution to be tested:

[0070] 1.1. Matrix purification: Sodium alginate, hydroxyapatite, biomimetic materials and electrochemical methods were selected for matrix pretreatment until a relatively stable electrochemical test matrix baseline was obtained. Among them, the material use conditions are as follows: adjust the pH of the solution: 6-7, the stirring speed of the solution: 200rpm, the rea...

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Abstract

The invention discloses an electrochemical detection method for multiple types of harmful elements in traditional Chinese medicinal materials and preparations thereof. Pretreatment is carried out on the to-be-tested solution by using a removal material and / or an electrodeposition method until the purified matrix solution obtains a stable electrochemical test matrix baseline, and the removal material comprises one or a combination of more of hydroxyapatite, sodium alginate and a biomimetic material; a nano electrode is prepared on the working electrode of a three-electrode system; qualitative oxidation-reduction potentials of various types of harmful elements in the purified matrix solution are determined by using a nano electrode; and a quantitative oxidation dissolution curve of each typeof harmful elements is determined based on the nano electrode and a square wave dissolution voltammetry or a differential pulse dissolution voltammetry, data are fit to obtain a working curve, the harmful elements in an actual sample are detected, and the detected harmful elements are compared with the working curve to determine the types and the contents of the harmful elements. The method ensures that no redundant traditional Chinese medicine components damage a test system, realizes combination and rapid detection of multiple types of harmful elements, and is high in test accuracy.

Description

technical field [0001] The invention relates to the technical field of detection of harmful elements in Chinese medicinal materials and their preparations, in particular to an electrochemical detection method for multiple types of harmful elements in Chinese medicinal materials and their preparations. Background technique [0002] As a natural medicine, traditional Chinese medicine is widely used due to its characteristics of less toxic and side effects, safe use, and good curative effect. However, with the increasing environmental pollution and the use of pesticides and fertilizers containing heavy metals, there is a problem of pollution of harmful elements in Chinese herbal medicines and their preparations. Harmful elements refer to heavy metals such as lead, mercury, cadmium, copper, chromium, and arsenic. There are certain health risks in the decoction pieces of traditional Chinese medicine or its finished preparations polluted by harmful elements. Heavy metals interact...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/48G01N27/30
CPCG01N27/30G01N27/308G01N27/48
Inventor 杨美华孔丹丹骆骄阳王蓉闫卉欣李歆悦
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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