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Intelligent tissue adhesion resistant polymer composite material, tissue adhesion resistant aqueous humor drainage device and preparation method thereof

A composite material and polymer technology, applied in the field of treatment of refractory glaucoma, can solve problems such as poor drainage of aqueous humor and failure of implantation of aqueous humor drainage device

Pending Publication Date: 2020-08-18
SHANGHAI HAOHAI BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problem of failure of the implantation of the aqueous humor drainage device due to the poor drainage of the aqueous humor drainage caused by the tissue scarring around the drainage plate of the aqueous humor drainage device

Method used

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  • Intelligent tissue adhesion resistant polymer composite material, tissue adhesion resistant aqueous humor drainage device and preparation method thereof
  • Intelligent tissue adhesion resistant polymer composite material, tissue adhesion resistant aqueous humor drainage device and preparation method thereof
  • Intelligent tissue adhesion resistant polymer composite material, tissue adhesion resistant aqueous humor drainage device and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The preparation method of an anti-tissue adhesion aqueous humor drainage device provided by the present invention comprises:

[0061] The drainage plate is prepared by hot molding silicone rubber prepolymer, and the silicone rubber prepolymer includes silicone rubber raw material (that is, the main body of the hydrophobic material), a cross-linking agent (silicone rubber cross-linking agent) and a microstructure Conditioner. The microstructure regulator can chemically react with the silicone rubber raw material or the crosslinking agent to form an auxiliary molecular network structure (that is, the second network structure) in the process of forming the silicone rubber main molecular network (that is, the first network structure). structure). The silicone rubber crosslinking agent is mainly a type of low molecular weight siloxane that can chemically react with the silicone rubber raw material molecules.

[0062] The silicone rubber raw material, the cross-linking agen...

Embodiment 2

[0066] The preparation method is basically similar to Example 1, the difference is as described below.

[0067] The flow control valve provided at the connection between the drainage tube and the drainage plate has a cross quartering structure.

[0068] The microstructure regulator in the silicone rubber prepolymer used to prepare the drainage disc is polyethylene glycol dimethacrylate, wherein the polyethylene glycol molecular segment molecular weight is 700; the microstructure regulator is prepolymerized in silicone rubber The addition ratio in the product is 2.5%.

[0069] The static contact angle of the surface of the drain plate prepared in this example was 34.8° after 60 minutes.

Embodiment 3

[0071] The preparation method is basically similar to Example 1, the difference is as described below.

[0072] The flow control valve provided at the connection between the drainage tube and the drainage plate has a 120-degree trisection structure.

[0073] The microstructure regulator in the silicone rubber prepolymer used to prepare the drainage disc is a linear methacryloyl polyethylene glycol-polydimethylsiloxane copolymer, wherein the polyethylene glycol molecular segment molecular weight is 1300, the molecular weight of the polydimethylsiloxane segment is 1200; the addition ratio of the microstructure modifier in the silicone rubber prepolymer is 3.0%.

[0074] The static contact angle of the surface of the drainage tray prepared in this example was 8.6° after 60 minutes.

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Abstract

The invention discloses an intelligent tissue adhesion resistant polymer composite material, a tissue adhesion resistant aqueous humor drainage device and a preparation method thereof. The intelligenttissue adhesion resistant polymer composite material is formed by chemical crosslinking of a hydrophobic material main body, a crosslinking agent and a microstructure regulator, wherein the microstructure regulator is selected from a group consisting of a polyethylene glycol polymer with a chemical reaction functional group and derivatives thereof. The aqueous humor drainage device is made of theintelligent tissue adhesion resistant polymer composite material; the production process is simple and convenient, the surface polymer molecular conformation can be adjusted according to the environment, non-specific adhesion of proteins, cells and tissues on the surface of a drainage disc is inhibited, the scarring process of tissues around the drainage disc is fundamentally prevented, the rootcause of unsmooth drainage of the aqueous humor drainage device is eliminated, and the success rate of implantation of the aqueous humor drainage device is increased.

Description

technical field [0001] The invention belongs to the field of ophthalmic medical devices, and in particular relates to an intelligent anti-tissue adhesion polymer composite material, an anti-tissue adhesion aqueous humor drainage device and a preparation method thereof. The aqueous humor drainage device is suitable for glaucoma, especially refractory glaucoma Treatment. Background technique [0002] Glaucoma is a very harmful common eye disease, ranking first among irreversible blinding eye diseases. For the treatment of glaucoma, according to the severity, eye drops, laser or surgery can be used respectively; for refractory glaucoma that cannot be treated by the above conventional methods, the current treatment is more difficult. The main reason for operation failure is the adhesion of fibroblasts in the operation area, and the resulting tissue fibrosis and scar formation, which hinder the drainage and diffusion of aqueous humor. [0003] Although the implantation of aqueo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L83/04C08L71/02C08L83/12C08J3/24A61M1/00
CPCA61M1/0023A61L2300/424A61M2210/0612A61M1/74A61M1/84C08J3/246C08J2383/04C08J2471/02C08J2483/12A61M2210/005
Inventor 孙建国孙兴怀
Owner SHANGHAI HAOHAI BIOLOGICAL TECH
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