A raw material drug reaction purification system and its process method for integrated energy utilization
A process method and technology for raw materials, which are applied in the field of raw material drug reaction and purification systems to achieve the effects of reducing usage and consumption
Active Publication Date: 2022-06-17
SINOPEC SHANGHAI ENG +1
View PDF1 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Due to the characteristics of the batch process and its complexity and time-varying nature, this method has certain limitations in the application of energy comprehensive optimization of the batch process
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0060] In the present embodiment: for the cooling capacity in the process stream liquid ammonia, an ethylene glycol storage tank is added to store a certain amount of normal temperature ethylene glycol as an intermediate medium to exchange the heat required for liquid ammonia gasification and temperature rise in R01 . In the process of heat exchange, by controlling the flow rate of circulating water in E01, the temperature at the outlet of circulating water is raised to 85°C, and then allocated to R02 to reduce the use of hot water in public works. After the low-temperature ethylene glycol used in R04 is circulated to the outlet, it is directly distributed to E02 for use instead of low-temperature water. Adjust the production time of each equipment so that the energy matches the equipment to produce at the same time. Specific steps are as follows:
[0061] S1: the reactant and the liquid ammonia of -35 ℃ are dropped into the first reactor 1, and the reaction is carried out a...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention discloses a raw material drug reaction purification system for energy integration and utilization. In the traditional raw material drug reaction purification system, a stream of ethylene glycol at normal temperature is added, and the heat to be absorbed by the gasification of the process stream liquid ammonia and the temperature rise is combined with it. The low-temperature ethylene glycol required by the crystallization kettle is produced; the high-grade heat released by the liquefaction of the gaseous solvent is absorbed by the circulating water to generate lower temperature hot water, which is supplied to the second reaction kettle; the low-temperature ethylene glycol at the outlet of the crystallization kettle Glycol has a lower temperature than warm water and has a higher grade as a refrigerant, so it can replace low-temperature water. The purification system of the present invention effectively reduces the consumption of low-temperature ethylene glycol, hot water and low-temperature water, further utilizes the remaining energy, and reduces the consumption of public works. The invention also discloses a raw material drug reaction purification process method of energy integration and utilization. The process method has low energy consumption and reduces costs while saving energy, reducing emissions and protecting the environment.
Description
technical field [0001] The invention relates to the technical field of crude drug production, in particular to a crude drug reaction purification system for integrated energy utilization and a process method thereof. Background technique [0002] Pharmaceutical and chemical production consumes a lot of energy, and today's society is facing a severe test of energy shortage. With the development of social economy, people's demand for fine chemicals such as pharmaceutical products is increasing day by day. How to effectively reduce energy consumption in production is an urgent problem to be solved. [0003] The method for producing itraconazole crude drug disclosed in Chinese patent CN201710717004.5 adopts three kinds of stepped temperatures of high, medium and low of the same heat exchange medium to control the temperature change of the liquid in each reactor. In the case of large gradient changes, the method of buffer transition and mild temperature change is adopted to avoi...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Patents(China)
IPC IPC(8): B01J19/18B01D3/00B01D5/00B01D9/02
CPCB01J19/0053B01J19/1862B01D9/0013B01D3/007B01D5/0039B01J2219/00087
Inventor 钟剑锋程华尤超
Owner SINOPEC SHANGHAI ENG