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Vacuum freeze-drying method for preserving effective ingredients in radix angelicae sinensis medicinal material

A technology of vacuum freeze-drying and active ingredients, which is applied to medical preparations containing active ingredients, preliminary treatment to promote the drying of solid materials, and pharmaceutical formulations, etc. question

Pending Publication Date: 2020-08-28
云南昊辰食品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, regarding the vacuum freeze-drying process of angelica medicinal materials in the prior art, the evaluation index of medicinal material quality is single and not comprehensive enough, which is not conducive to ensuring the quality of angelica medicinal materials.

Method used

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  • Vacuum freeze-drying method for preserving effective ingredients in radix angelicae sinensis medicinal material
  • Vacuum freeze-drying method for preserving effective ingredients in radix angelicae sinensis medicinal material
  • Vacuum freeze-drying method for preserving effective ingredients in radix angelicae sinensis medicinal material

Examples

Experimental program
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Effect test

preparation example Construction

[0111] (1) Preparation of the test solution: Take about 1.0 g of the powder of this product (passed through a No. 3 sieve), accurately weigh it, put it in a stoppered conical flask, add 20 mL of 70% methanol precisely, seal it tightly, weigh it, Heat to reflux for 30 minutes, let cool, weigh again, make up the lost weight with 70% methanol, shake well, let stand, take the supernatant and filter, and take the subsequent filtrate to obtain the final product.

[0112] (2) Preparation of reference solution: accurately weigh tryptophan, chlorogenic acid, ferulic acid, ligustilide I, ligustilide H, imperatorin, Z-ligustilide, butene An appropriate amount of phthalide reference substance was prepared by adding methanol to make 50 μg of tryptophan, 70 μg of chlorogenic acid, 55 μg of ferulic acid, 16 μg of ligustonin I, 5 μg of listonin H, 190 μg of imperatorin, and A solution of 500 μg of this lactone and 50 μg of butenylphthalide is obtained.

[0113](3) Chromatographic conditions:...

Embodiment 1

[0117] The vacuum freeze-drying method of preserving active ingredient in the angelica medicinal material of the present embodiment comprises the steps:

[0118] (1) Pre-treatment: Remove the stems and leaves from the underground part of the excavated Weixi fresh angelica medicinal material, then rinse with clean water to remove sediment and surface attachments, wash, and drain the surface water for later use.

[0119] (2) Pre-freezing: Randomly weigh and wash the fresh taproots of Angelica sinensis, put them into an ultra-low temperature refrigerator, and pre-freeze to -30°C, and the pre-freezing process ends.

[0120] (3) Sublimation drying: Place the pre-frozen Chinese angelica medicinal material on a partition made of heat-conducting material in the drying room, and put a temperature sensor through the medicinal material to monitor the temperature of the medicinal material. Start vacuuming, keep the vacuum pressure at 0 Pa, and keep the partition temperature at 0°C for sub...

Embodiment 2

[0127] The vacuum freeze-drying method of preserving active ingredient in the angelica medicinal material of the present embodiment comprises the steps:

[0128] (1) Pre-treatment: Remove the stems and leaves from the underground part of the fresh angelica medicinal material from Dali Machang after excavation, and then rinse it with clean water to remove the sediment and surface attachments, wash it, and drain the surface water for later use.

[0129] (2) Pre-freezing: Weigh and wash fresh fibrous roots of Angelica sinensis randomly, put them into an ultra-low temperature refrigerator, and pre-freeze to -35°C, and the pre-freezing process ends.

[0130] (3) Sublimation drying: Place the pre-frozen Chinese angelica medicinal material on a partition made of heat-conducting material in the drying room, and put a temperature sensor through the medicinal material to monitor the temperature of the medicinal material. Start vacuuming, keep the vacuum pressure at 40Pa, and keep the pa...

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Abstract

The invention relates to a vacuum freeze-drying method for preserving effective ingredients in a radix angelicae sinensis medicinal material. The vacuum freeze-drying method includes the following steps of preprocessing, precooling, lyophilization, parsing and sealed preservation. The established radix angelicae sinensis freeze-drying method can better guarantee the quality of the radix angelicaesinensis medicinal material and considers time cost while ensuring the quality of the medicinal material. The radix angelicae sinensis medicinal material obtained through the established radix angelicae sinensis freeze-drying method basically keeps the appearance unchanged, is loose in texture, easy to smash, low in water content and easy to store, meanwhile quite well remains the main effective ingredients in the radix angelicae sinensis medicinal material, has quite high practicability and is suitable for large-scale production.

Description

technical field [0001] The invention relates to a vacuum freeze-drying method, in particular to a vacuum freeze-drying method for preserving active ingredients in angelica medicinal materials, and belongs to the field of processing technology of Chinese medicinal materials. Background technique [0002] The primary processing of medicinal materials in the origin is a key technology in the quality control of medicinal materials, which directly or indirectly affects the chemical components in medicinal materials, resulting in uneven yield and quality of medicinal materials. For the drying processing of Chinese medicinal materials, it is usually divided into two categories, which are divided into traditional drying methods and processing methods using modern technology. Common traditional drying methods for Chinese medicinal materials include sun drying, shade drying and drying methods; modern drying processing technologies include solar Drying, far infrared drying, microwave d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): F26B1/00F26B5/06A61K36/232A61K125/00
CPCA61K36/232A61K2236/13A61K2236/15A61K2236/17F26B1/00F26B1/005F26B5/06
Inventor 熊毅李俊邓雪琪饶高雄代荣华
Owner 云南昊辰食品有限公司
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