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Targeted controlled-release anti-arthritis medicinal preparation and preparation method thereof

An anti-arthritis and pharmaceutical preparation technology, applied in the fields of polymer chemistry, biomedical materials and pharmacy, can solve the problems of limiting further clinical application, poor response of anti-rheumatic drugs, etc., and achieve inhibition of joint synovial inflammation and bone erosion, The effect of controlled release

Pending Publication Date: 2020-09-04
PEOPLES HOSPITAL OF HENAN PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, about 30% of patients still do not respond well to existing antirheumatic drugs
For this reason, rheumatologists have conducted a lot of research, and repeated intraperitoneal injection of tripterine (Cel) to reduce synovial inflammation and bone erosion in RA joints. Due to the rapid drug metabolism and organ toxicity, the further clinical application is greatly limited. possible

Method used

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  • Targeted controlled-release anti-arthritis medicinal preparation and preparation method thereof
  • Targeted controlled-release anti-arthritis medicinal preparation and preparation method thereof
  • Targeted controlled-release anti-arthritis medicinal preparation and preparation method thereof

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Embodiment 1

[0026] A method for preparing a targeted and controlled-release anti-arthritic drug preparation, the preparation steps are as follows:

[0027] (1) Dissolve 50 mg of PEG-PPS and 5 mg of tripterine (Cel) in 5 mL of tetrahydrofuran;

[0028] (2) Under ultrasonic dispersion, add the solution obtained in step (1) to 50 mL of deionized water, vacuum distill to remove tetrahydrofuran, repeat ultrafiltration 3 times, remove large polymers and free tripterine, 0.22 After filtration with a μm sterile microporous membrane, an anti-arthritic nanomedicine preparation with a concentration of 1 mg / mL (calculated in Cel) was obtained.

[0029] The atomic force microscope picture of the nano drug preparation prepared in this embodiment is shown in figure 1 . Depend on figure 1 It can be seen that the obtained nano drug preparation has a spherical nano morphology.

[0030] The particle size distribution diagram of the nano-pharmaceutical preparation prepared in this embodiment is shown in ...

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Abstract

The invention belongs to the technical field of polymer chemistry, biomedical materials and pharmacy, and discloses a targeted controlled-release anti-arthritis medicinal preparation and a preparationmethod thereof. The pharmaceutical preparation is a drug-loaded micelle, the drug-loaded micelle is composed of a segmented copolymer PEG-PPS and tripterine, and the tripterine is loaded in the micelle formed by the segmented copolymer PEG-PPS. The preparation method comprises the following preparation steps: (1) dissolving 20-80 parts by mass of PEG-PPS and 1-10 parts by mass of tripterine in 5-10 parts by volume of tetrahydrofuran; and (2) under ultrasonic dispersion, adding the solution obtained in the step (1) into 50-100 parts by volume of water, carrying out vacuum distillation to remove tetrahydrofuran, and carrying out repeated ultrafiltration and sterile microporous filtration membrane filtration to obtain the anti-arthritis nano-drug preparation. The medicinal preparation disclosed by the invention is sensitive to rheumatoid arthritis inflammation, controllable release of the medicine can be realized, and joint synovitis and bone erosion can be obviously inhibited.

Description

technical field [0001] The invention belongs to the technical fields of polymer chemistry, biomedical materials and pharmacy, and specifically relates to a targeted and controlled release anti-arthritic drug preparation and a preparation method thereof. Background technique [0002] Rheumatoid arthritis (RA) is a systemic autoimmune disease mainly manifested by joint involvement. According to the latest epidemiological survey data, in mainland China, the incidence rate of RA is about 0.42%, and the disability rate is as high as 61.3% after a course of more than 15 years. disease, which imposes a heavy burden on families and society. The goal of rheumatoid arthritis treatment is to reduce morbidity and complications. However, about 30% of patients still respond poorly to existing antirheumatic drugs. For this reason, rheumatologists have conducted a lot of research, and repeated intraperitoneal injection of tripterine (Cel) to reduce synovial inflammation and bone erosion ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/56A61K47/34A61P19/02A61P37/02B82Y5/00
CPCA61K9/1075A61K31/56A61K47/34A61P19/02A61P37/02B82Y5/00
Inventor 李景果安乐美栗占荣石刘奇
Owner PEOPLES HOSPITAL OF HENAN PROV
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