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Application of mln4924 in the preparation of choroidal neovascularization therapeutic drugs

A technology of new blood vessels and therapeutic drugs, applied in the field of medicine, can solve the problems of non-response, repeated intraocular injection of anti-VEGF drugs, etc., and achieve the effects of avoiding side effects, excellent effect, and reducing exudation

Active Publication Date: 2022-05-06
NANTONG UNIVERSITY
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  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to provide an ubiquitin-like modification inhibitor-MLN4924 in the treatment of choroidal neovascularization, so as to solve the problem of repeated intraocular injection and non-response of anti-VEGF drugs in the prior art

Method used

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  • Application of mln4924 in the preparation of choroidal neovascularization therapeutic drugs
  • Application of mln4924 in the preparation of choroidal neovascularization therapeutic drugs
  • Application of mln4924 in the preparation of choroidal neovascularization therapeutic drugs

Examples

Experimental program
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Effect test

Embodiment

[0027] (1) Establishment of mouse CNV model

[0028] Krypton laser induced CNV mice, anesthetized by intraperitoneal injection of 0.5% pentobarbital, compound tropicamide for mydriasis, and irradiated with hand-held light to keep the mouse body temperature. The mouse experimental eye was fixed in front of the slit lamp, with the aid of 1% methylcellulose, a 5.4mm hand-held contact lens was placed in front of the cornea, and a krypton ion laser was used, with a laser wavelength of 647.1nm, a power of 300mw, and a spot diameter. 50 μm, exposure time 0.05 seconds. Around the optic disc and equidistant photocoagulation at 2 nipple diameters away from the optic disc, a total of 4 points, located at 3, 6, 9, and 12 points, respectively, when bubbles are seen, it indicates that Bruch's membrane has been broken, and no vitreous hemorrhage is light. Criteria for success.

[0029] (2) Intraperitoneal injection of mice

[0030]Mice in CNV group were randomly divided into five groups: ...

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Abstract

The invention relates to the technical field of medicine, in particular to the application of MLN4924 in the preparation of choroidal neovascularization therapeutic drugs. The advantages of the present invention are: the present invention provides the application of MLN4924 in the treatment of choroidal neovascularization, and solves the problems of repeated intraocular injection of anti-VEGF drugs and unresponsiveness of some patients in the prior art. And MLN4924 is administered by intraperitoneal injection, avoiding multiple intraocular injections and possible side effects such as endophthalmitis. Through animal experiments, MLN4924 is better than the current clinical anti-VEGF drug ranibizumab in reducing the exudation, area and volume of CNV.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a kind of ubiquitin-like modification inhibitor-MLN4924 in the preparation of choroidal neovascularization therapeutic drugs. Background technique [0002] Age-related macular degeneration (AMD) is a progressive and degenerative eye disease that occurs in people over the age of 50. According to pathological changes, AMD is divided into two categories: dry and wet. Dry AMD is characterized by atrophy of the retinal pigment epithelium and the photoreceptor cells on it, while wet AMD mainly leads to pathological choroidal neovascularization (CNV), which is characterized by abnormal blood vessel growth in the central area of ​​the retina, that is, the submacular. Characteristically, these abnormal blood vessels break through Bruch's membrane and penetrate deep into the subretinal area of ​​the pigment epithelium, resulting in exudation, hemorrhage, retinal edema,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/519A61P9/00
CPCA61K31/519A61P9/00
Inventor 刘晓娟朱曼辉孙晓雷李爱红郭爱松
Owner NANTONG UNIVERSITY
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