Application of MLN4924 in preparation of choroidal neovascularization treatment medicines
A technology for new blood vessels and therapeutic drugs, applied in the field of medicine, can solve the problems of non-response, repeated intraocular injection of anti-VEGF drugs, etc., and achieve the effect of reducing exudation and excellent effect
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[0027] (1) Establishment of mouse CNV model
[0028] Krypton laser induced CNV mice, anesthetized by intraperitoneal injection of 0.5% pentobarbital, compound tropicamide for mydriasis, and irradiated with hand-held light to keep the mouse body temperature. The mouse experimental eye was fixed in front of the slit lamp, with the aid of 1% methylcellulose, a 5.4mm hand-held contact lens was placed in front of the cornea, and a krypton ion laser was used, with a laser wavelength of 647.1nm, a power of 300mw, and a spot diameter. 50 μm, exposure time 0.05 seconds. Around the optic disc and equidistant photocoagulation at 2 nipple diameters away from the optic disc, a total of 4 points, located at 3, 6, 9, and 12 points, respectively, when bubbles are seen, it indicates that Bruch's membrane has been broken, and no vitreous hemorrhage is light. Set success criteria.
[0029] (2) Intraperitoneal injection of mice
[0030]Mice in CNV group were randomly divided into five groups: ...
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