Functionalized graphene loaded with curcuma extract, preparation method and application of functionalized graphene

A technology of turmeric extract and graphene, which is applied in the field of functionalized graphene loaded with turmeric extract, can solve the problems of low yield, inability to fully exert the antibacterial effect of turmeric extract, and low effective utilization rate

Inactive Publication Date: 2020-10-20
江苏益飞环保科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But because the extraction process in the turmeric root extract is comparatively complicated, the productive rate is lower
However, the post-finishing process of cotton fabrics cannot fully exert the antibacterial effect of turmeric extract, and its effective utilization rate is low.

Method used

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  • Functionalized graphene loaded with curcuma extract, preparation method and application of functionalized graphene

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preparation example Construction

[0042] Graphene oxide has the advantages of low cost, easy modification, and large surface area. It is an excellent drug carrier and a new type of antibacterial nanomaterial. Therefore, the applicant modified the surface of the graphene oxide material, and the functionalized graphene has the effect of efficiently resisting respiratory bacteria and viruses, and can efficiently load xanthodiol at the same time. The problem of contact with bacteria and viruses, the difficult problem that the efficacy of medicine is difficult to be fully exerted. Finally, the synergistic effect of Huanggen II and nanomaterials is realized. Its specific preparation method is as follows: the preparation method of the functionalized graphene of load turmeric extract, it is characterized in that, comprises the following steps: in ice bath, the condition of stirring, slowly add 10g graphite powder and 5g sodium nitrate mixture in the concentrated sulfuric acid of 250mL , continue to stir for 2 to 5 mi...

Embodiment 1

[0046] Extraction of active ingredients in turmeric: get 2kg turmeric to wash, pulverize, add acid and hydrolyze, centrifuge to separate solid hydrolyzate; use ethyl acetate as extractant, carry out reflux extraction, the volume-to-mass ratio of extractant to solid hydrolyzate during extraction 4:1, extract for 3 hours; then adjust the pH to 8.5 with ammonia water in the purified solution; take the supernatant, use ethyl acetate as the extractant, and carry out reflux extraction to obtain the turmeric root extract; concentrate the turmeric root extract to the original After 1 / 3 of the volume, carry out 200 mesh silica gel column chromatography, then use No. 6 gasoline, chloroform volume ratio as solvent elution 4h, utilize ultraviolet detector, at 230nm, collect xanthoradiol according to the peak Crude crystals; dissolve the crude crystals of xanthoradiol with ethanol solution respectively, filter, concentrate the filtrate to 5 times of the weight of the original crude crystals...

Embodiment 2

[0050] The extraction of active ingredient in turmeric: with embodiment 1.

[0051] Preparation of functionalized graphene loaded with turmeric extract: under conditions of ice bath and stirring, slowly add 10 g of graphite powder and 5 g of sodium nitrate mixture into 250 mL of concentrated sulfuric acid, continue stirring for 3 min, then add 30 g of potassium permanganate powder, fully Stir until the temperature stabilizes to room temperature, heat the temperature to 40°C, continue stirring for 45 minutes, then slowly add deionized water, dilute to 8 times the original volume with ionized water, then add a certain amount of hydrogen peroxide solution, filter, and dilute with hydrochloric acid The solution also cleaned the filter cake, and finally dried graphene oxide; 0.15g graphene oxide was added in 150mL of water, and a uniform dispersion was formed under the action of ultrasonic waves, and then the pH of the solution was adjusted to 10 by sodium carbonate, and then hydraz...

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Abstract

The invention discloses functionalized graphene loaded with a curcuma extract as well as a preparation method and application of the functionalized graphene, and belongs to the field of medical protective articles. The preparation method comprises the following steps of preparation of graphene oxide, preparation of sulfonated graphene, preparation of functionalized graphene, and preparation of functionalized graphene loaded with the curcuma extract. By combining hydrophobic drug curcumin with the functionalized graphene, the characteristics of a nano material and the excellent antibacterial and antiviral pharmacological activity of the curcuma longa root extract are brought into full play, and meanwhile, the problems of poor water solubility, low effective utilization rate and the like ofcurcumin are solved. In addition, in cooperation with an after-finishing process, the functionalized graphene loaded with the curcuma extract is fixed to the cotton fabric as a facing material.

Description

technical field [0001] The invention belongs to the field of medical protective products, in particular to a functionalized graphene loaded with turmeric extract, its preparation method and application. Background technique [0002] When respiratory infectious diseases are prevalent, or when working in a polluted environment such as dust, wearing a mask has a very good effect, and it can filter out bacteria or pollutants by filtering. However, as people pay more and more attention to personal protection against bacteria, viruses, pollutants, etc., and since masks are mostly made of cloth or paper, especially ordinary medical surgical masks, during long-term wearing, the water vapor exhaled by the human body Or the sweat discharged will adhere to the surface of the mask, providing suitable growth conditions for filtering bacteria or pollutants on the surface of the mask. Therefore, the continuous time of such masks should not be too long, and it is not recommended to use the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): D06M11/74D06M13/148D06M13/144D06P1/00D06P1/673D06P1/651D06P3/60C01B32/198C01B32/184C01B32/194D06M101/06
CPCC01B32/184C01B32/194C01B32/198D06M11/74D06M13/144D06M13/148D06M16/00D06M2101/06D06P1/0032D06P1/65118D06P1/673D06P3/60
Inventor 毛创建易书禄
Owner 江苏益飞环保科技有限公司
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