Product capable of regulating CYP1A1 gene expression

A gene expression and product technology, applied in the field of microorganisms, can solve the problems of increased expression of CYP1A1 gene and difficult realization, achieve high application prospects, and improve the effect of human intestinal health
CN111869879APending Publication Date: 2020-11-03JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2020-11-03

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Abstract

The invention discloses a product capable of regulating CYP1A1 gene expression, and belongs to the technical field of microorganisms. The invention provides a product, the effective component of the product is Lactobacillus plantarum CCFM8661, and the Lactobacillus plantarum CCFM8661 can effectively regulone the human body CYP1A1 gene expression, which is specifically reflected in thon (1) ponhological damage of benzopyrene exposed mouse colonic tissue is significantly improved; (2) the mRNA expression level of the CYP1A1 gene in the colon of the mouse exposed by benzopyrene is remarkably improved, so that the product provided by the invention has an extremely high application prospect in regulating the expression of the CYP1A1 gene of a human body and improving the intestinal health of the human body.
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Description

technical field

[0001] The invention relates to a product capable of regulating CYP1A1 gene expression, belonging to the technical field of microorganisms. Background technique

[0002] CYP1A1 gene encodes P450 oxidative metabolic enzymes, and P450 oxidative metabolic enzymes can convert a variety of xenobiotics into derivatives of cytotoxins or mutagenic substances of organisms. For example, benzopyrene will be converted into highly carcinogenic substance 7,8-dihydroxy-9,10-epoxybenzopyrene (7,8-dihydroxybenzopyrene-9,10- oxide, BPDE); polycyclic aromatic hydrocarbons (polycyclic aromatichydrocarbons, PAH) will be converted into cytotoxins or other carcinogens under the metabolism of P450 oxidative metabolic enzymes. In addition, P450 oxidative metabolic enzymes also mediate the conversion of estrogen into catechol estrogen, which is carcinogenic. It can be seen that keeping the expression of CYP1A1 gene in the human body at a low level for a long time is very important f...

Claims

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