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High-performance processable hydrogel as well as preparation method and application thereof

A polymer hydrogel and hydrogel technology, applied in the field of polymer chemical materials, can solve problems such as poor fit, limited application, and gap in mechanical properties, and achieve the effect of promoting mineralization and high application prospects

Pending Publication Date: 2022-07-19
PEKING UNIV THIRD HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrogel itself lacks biological activity, and its mechanical properties still have a large gap compared with osteochondral, and the degree of fit with the receptor is poor, which limits its application in clinical orthopedics.

Method used

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  • High-performance processable hydrogel as well as preparation method and application thereof
  • High-performance processable hydrogel as well as preparation method and application thereof
  • High-performance processable hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1. Preparation of Sodium Alginate Hydroxyapatite Particle Hybrid Polyvinyl Alcohol Hydrogel

[0054] The polyvinyl alcohol PBS solution was mixed with hydroxyapatite particles with a particle size of 10 nm to obtain a polyvinyl alcohol PBS mixed solution with a mass percentage of 1% of the bioceramic material particles, and sodium 4-carboxyphenyl borate was added to sodium alginate (average The relative molecular weight is 150 kDa) and mixed evenly in the PBS solution to obtain a PBS mixed solution with an alginate mass percentage of 60%. After mixing the above two solutions uniformly, a cylindrical hydrogel sample was obtained by hand molding. The mass percentages of alginate, bioceramic material particles, 4-carboxyphenylboronic acid and polyvinyl alcohol in the obtained final target hydrogel are 50%, 0.5%, 3% and 7%, respectively.

[0055] Test the compression curve of the hydrogel sample obtained in this example, and the results are as follows figure 1 sho...

Embodiment 2

[0057] Example 2. Preparation of Potassium Alginate-Bioactive Glass Particles and Silica Particles Hybrid Dextran Hydrogel

[0058] The mixture obtained by mixing bioactive glass particles with a particle size of 100 μm and silica particles with a particle size of 100 μm according to a mass ratio of 1:1 was added to the dextran aqueous solution to obtain a dextran with a mass percentage of 10% of the bioceramic material particles. mixed aqueous solution;

[0059] Mixing potassium alginate (average relative molecular mass is 5kDa) with epichlorohydrin to obtain a homogeneous aqueous solution with a mass percentage of alginate of 50%;

[0060] After mixing the above two solutions, follow the figure 2In the hand molding process shown in (a), hydrogel samples with different letter shapes are obtained by hand molding; wherein, the obtained final target hydrogel contains potassium alginate, bioceramic material particles, dextran, epoxy The mass percentages of chloropropane are 40...

Embodiment 3

[0062] Example 3. Calcium alginate, ammonium alginate-silica particles and calcium carbonate bone cement particles and calcium sulfate particles and calcium carbonate particles Hybrid polyethylene glycol-polylactic acid copolymer, polyglycolide / lactide Preparation of Ester Copolymer and Polyglycolactone Copolymer Hydrogel

[0063] Silica particles with a particle size of 100 nm, calcium carbonate bone cement particles with a particle size of 80 nm, calcium sulfate particles with a particle size of 10 μm, and calcium carbonate particles with a particle size of 20 nm were added to polyethylene in a mass ratio of 1:2:1:2. The mixed aqueous solution of glycol-polylactic acid copolymer, polyglycolide / lactide copolymer and polyglycolactone copolymer is stirred evenly to obtain a mixed aqueous solution with a mass percentage of bioceramic material particles of 15%. Calcium alginate and ammonium alginate are made into an aqueous solution with an alginate mass percentage of 30% accordi...

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Abstract

The invention discloses a high-performance processable hydrogel and a preparation method and application thereof, the hydrogel comprises a processable polymer hydrogel matrix and an interpenetrating network structure and / or a semi-interpenetrating network structure formed in the matrix based on a dispersion system of alginate and a biological ceramic material, therefore, the hydrogel can entrap biological ceramic material particles with bone repair inducing capacity and other types of bioactive substances such as drugs, bioactive molecules or cells, so that the hydrogel can load and convey the bioactive substances. And by reasonably optimizing the ratio of the components in the gel network, the mechanical properties of the gel network are adjusted, the differentiation capability of irregular force-bearing osteoblasts is induced and supported, and mineralization is promoted. Therefore, the hydrogel obtained by the invention has a relatively high application prospect in the fields of disease treatment and tissue engineering.

Description

technical field [0001] The invention belongs to the field of polymer chemical materials, and in particular relates to a high-performance processable hydrogel and a preparation method and application thereof. Background technique [0002] Bioceramic materials such as classic bioglass ( BG), hydroxyapatite, calcium phosphate bone cement, calcium sulfate, calcium carbonate, silicon dioxide, etc., the composition of which is similar to that of natural bones. Clinical studies have confirmed that bioceramic materials have the ability to induce bone and combine with bone. Such as (Hench LL, Polak JM.Third-generation biomedicalmaterials[J].Science.2002;295(5557):1014-7; Jones JR.Review of bioactiveglass:From Hench to hybrids[J].Acta Biomaterialia.2013;9 :4457-4486; Marelli B, Ghezzi CE, Mohn D, et al.Accelerated mineralization of dense collagen-nanobioactive glass hybrid gels increases scaffold stiffness and regulates sosteoblastic function[J].Biomaterials.2011;32:8915-8926;Okeso...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/04C08L29/04C08L5/02C08L67/04C08K3/32C08K3/40C08K3/36C08K3/26C08K3/30C08K5/55A61L27/10A61L27/20A61L27/54A61L27/12A61L27/50
CPCC08J3/075A61L27/10A61L27/20A61L27/54A61L27/12A61L27/50C08J2305/04C08J2429/04C08J2405/02C08J2405/04C08J2467/04C08K3/32C08K3/40C08K3/36C08K2003/265C08K2003/3045A61L2430/02A61L2430/06A61L2400/06A61L2300/412A61L2300/102A61L2300/112C08L5/04
Inventor 田耘屈小中祝腾蛟赵嫣然刘冰川闵树元段叶晓
Owner PEKING UNIV THIRD HOSPITAL
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