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Application of epigallocatechin gallate in preparation of medicine for treating and/or preventing diseases caused by Epigallocatechin gallate virus infection

A technology of epigallocatechin and gallate, applied in antiviral agents, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of anti-free radical DNA damage, which needs further development, and reduce low-density cholesterol content And other issues

Pending Publication Date: 2020-11-13
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Many studies have shown that EGCG has anti-free radical DNA damage, scavenging free radicals, anti-radiation and ultraviolet rays, resisting the effects of pollution, sun exposure and smoking, and preventing skin aging and wrinkling; it can also prevent oil peroxidation, reduce serum Low-density cholesterol, ultra-low-density cholesterol, and triglyceride levels; can interfere with the signaling needed for cancer cell survival, inhibit dietary carcinogens, and work with other enzymes and antioxidants in the intestine, liver, and lungs to prevent The activity of certain carcinogens; it also has various physiological activities such as antithrombotic formation and inhibition of platelet aggregation, but its research and application in antiviral therapy are relatively limited, and further development is needed

Method used

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  • Application of epigallocatechin gallate in preparation of medicine for treating and/or preventing diseases caused by Epigallocatechin gallate virus infection
  • Application of epigallocatechin gallate in preparation of medicine for treating and/or preventing diseases caused by Epigallocatechin gallate virus infection
  • Application of epigallocatechin gallate in preparation of medicine for treating and/or preventing diseases caused by Epigallocatechin gallate virus infection

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Experimental program
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Embodiment 1

[0034] 1. Materials

[0035] Echovirus type 9: It is a clinical isolate from the First Affiliated Hospital of Zhengzhou University, derived from the cerebrospinal fluid of a patient with meningitis; Vero and Hep-2 cells are preserved in our department. EGCG was provided by Sigma Company, the concentration of the mother solution was 20 mg / ml, filtered and sterilized, and stored in the dark at 4°C. Anti-Respiratory Syncytial Virus rabbit polyclonal antibody (ab12253) and goat anti-rabbit IgG H&L (HRP) (ab6721) secondary antibody were purchased from Abcam in the United States, and anti-GAPDH rabbit polyclonal antibody was purchased from Hangzhou Xianzhi Biotechnology Co., Ltd.; small interference RNA (siRNAs) (siControl, cat. no. sc-37007).

[0036] 2 Test and Results

[0037] 2.1 Virus propagation

[0038] The Vero cells were subcultured one day in advance to multiply one bottle of cells into three bottles. The next day, when the cells grow to a monolayer of cells with a con...

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Abstract

The invention discloses an application of epigallocatechin gallate in preparation of a medicine for treating and / or preventing diseases caused by Epidemic diarrhea virus infection. The EGCG in-vitro anti-Erkovirus effect and mechanism are deeply discussed, the feasibility of the EGCG serving as an Erkovirus treatment medicine is verified, a theoretical basis is provided for research and development of natural products of Erkovirus inhibitors, and the product is expected to be used for treating various diseases caused by Erkovirus infection.

Description

technical field [0001] The invention relates to the medical application field of epigallocatechin gallate, in particular to the use of epigallocatechin gallate in preparing medicines for treating and / or preventing diseases caused by Eck virus infection. Background technique [0002] Tea polyphenols are a mixture of polyhydric phenols extracted from tea leaves with complex composition, different molecular weights, properties and chemical structures, among which flavanol compounds mainly composed of catechins are the main part of tea polyphenols. Catechins account for 60% to 80% of the total tea polyphenols, including epigallocatechin gallate (EGCG), epigallocatechin (EGC), epicatechin gallate (ECG), epigallocatechin gallate (ECG), Catechin (EC). [0003] Among them, epigallocatechin gallate (EGCG) is a unique catechin in tea, with the highest content, accounting for about 50% of tea polyphenol products, because there are 6 ortho phenolic hydroxyl groups in the structure and ...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P31/14
CPCA61K31/353A61P31/14
Inventor 汪洋张辉王静吴秋歌
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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