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Systems and methods for 3D reconstruction of anatomical organs and inclusions using short-wave infrared (SWIR) projection tomography

A projection and imaging technology, applied in the field of tomography, can solve problems such as the limitation of the accuracy of the forward model, and achieve the effect of improving the accuracy and performance

Pending Publication Date: 2020-11-20
PERKINELMER HEALTH SCIENCES INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the accuracy of the forward model, and thus the accuracy of tomographic reconstructions dependent on the forward model, is limited by the accuracy of the known optical properties of the tissue under study.

Method used

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  • Systems and methods for 3D reconstruction of anatomical organs and inclusions using short-wave infrared (SWIR) projection tomography
  • Systems and methods for 3D reconstruction of anatomical organs and inclusions using short-wave infrared (SWIR) projection tomography
  • Systems and methods for 3D reconstruction of anatomical organs and inclusions using short-wave infrared (SWIR) projection tomography

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Embodiment Construction

[0085] It is contemplated that the systems, devices, methods and processes of the invention include alterations and adaptations developed using information from the embodiments described herein. Adaptations and / or modifications of the systems, devices, methods, and processes described herein may be performed as contemplated by this specification.

[0086]Throughout the specification, when articles, apparatuses and systems are described as having, comprising or including particular components, or when processes and methods are described as having, comprising or including particular steps, it is contemplated that, in addition, there are The articles, apparatuses and systems of the invention consist of the recited components, and there are processes and methods according to the invention which consist essentially of or consist of the recited process steps.

[0087] It should be understood that the order of steps or order for performing certain actions is immaterial so long as the...

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Abstract

Presented herein are systems and methods for tomographic imaging of a region of interest in a subject using short-wave infrared light to provide for accurate reconstruction of absorption maps within the region of interest. The reconstructed absorption maps are representations of the spatial variation in tissue absorption within the region of interest. The reconstructed absorption maps can themselves be used to analyze anatomical properties and biological processes within the region of interest, and / or be used as input information about anatomical properties in order to facilitate data processing used to obtain images of the region of interest via other imaging modalities. For example, the reconstructed absorption maps may be incorporated into forward models that are used in tomographic reconstruction processing in fluorescence and other contrast-based tomographic imaging modalities. Incorporating reconstructed absorption maps into other tomographic reconstruction processing algorithmsin the manner improves the accuracy of the resultant reconstructions.

Description

technical field [0001] The present invention generally relates to methods and systems for tomography. More specifically, in certain embodiments, the present invention relates to tomography using shortwave infrared (SWIR) radiation. Background technique [0002] In vivo imaging of small mammals is performed by numerous researchers in fields as diverse as oncology, infectious disease, and drug discovery. A wide variety of techniques are involved in in vivo imaging of mammals, such as bioluminescence, fluorescence, tomography, and multimodal imaging. [0003] Many imaging modalities are tomographic methods. Tomography is based on the detection of light transmitted through or emitted from a sample in order to obtain an image of or infer the optical properties of the sample under study. For example, tomography can be used to reconstruct tissue uptake maps within a region of interest of a subject under study. In other applications, tomography is used to generate a map of the s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00A61B6/02A61B6/03A61B6/04G02B21/00G06T7/00G06T11/00
CPCA61B5/0062A61B5/0071A61B5/0073A61B2560/0223G01N2021/1787G01N21/35G01B11/24A61B5/0075A61B5/0035A61B2503/40G06T11/006G06T2211/456A61B5/704G06T11/005
Inventor 阿里·贝赫鲁兹
Owner PERKINELMER HEALTH SCIENCES INC