Use of compound and composition thereof for preparation of medicine for alleviating inflammation activity of lung cells

A technology for medicines and compositions, which is used in the field of medicines for the preparation of compounds and their compositions for relieving pulmonary cell inflammatory activity

Active Publication Date: 2020-12-01
百岳特生物科技(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are currently limited drugs that are known to be effective in alleviating the inflammatory activity of lung cells, and these drugs may not be able to alleviate the inflammatory activity of lung cells

Method used

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  • Use of compound and composition thereof for preparation of medicine for alleviating inflammation activity of lung cells
  • Use of compound and composition thereof for preparation of medicine for alleviating inflammation activity of lung cells
  • Use of compound and composition thereof for preparation of medicine for alleviating inflammation activity of lung cells

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1. Purification of compound TCI-ES-06~TCI-ES-15

[0043] The compound purified in this example is obtained from Elsholtzia ciliata Hylander, also known as Elsholtzia ciliata Hylander, which is an annual herb mainly distributed in Asia. The plant is known to be useful in the treatment of acute vomiting, diarrhea and heatstroke, and has a diuretic effect.

[0044] First, the extract of Lemongrass citronella is prepared, the whole plant of citronella citronella is washed and dried, and coarsely crushed with a pulverizer. Afterwards, the coarse crushed material of Lemongrass citronella was extracted with water as a solvent. The weight ratio of the mixture of the solvent and the crushed citronella citronella is in the range of 20:1 to 2:1. The extraction temperature is from 50°C to 100°C, preferably from 80°C to 90°C, and the extraction time is from 0.5 to 3 hours.

[0045] After cooling down to room temperature, the lemongrass citronella extract obtained throu...

Embodiment 2

[0060] Example 2. Efficacy Evaluation of Compounds TCI-ES-06~TCI-ES-15 in Relieving Pulmonary Cell Inflammation Activity

[0061] In this example, human normal lung epithelial cell line BEAS-2b (ATCC CRL-9609) purchased from American Type Culture Collection (ATCC) was used. The cells were cultured in Dulbecco's Modified Eagle's Medium (DMEM) (supplemented with 1% penicillin / streptomycin (Gibco) and 10% fetal bovine serum (FBS) ( Gibco)). Add 500 μL of culture medium to each well of a 24-well culture plate, so that each well has 5 x 10 4 BEAS-2b cells. After 24 hours of incubation at 37°C, removal of the medium did not disturb the attached cells.

[0062]Afterwards, the BEAS-2b cells were divided into 12 groups, including 10 experimental groups (ie, experimental groups 1-10), 1 LPS group and 1 control group. Add 1 μg / mL lipopolysaccharide (LPS) (Sigma) to the cells of LPS group and experimental group 1-10, add 10 μg / mL compound TCI-ES-06 to the cells of experimental group 1...

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PUM

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Abstract

The invention relates to a novel use of a composition, and particularly relates to a use of a compound and a composition thereof for preparation of a medicine for alleviating inflammation activity oflung cells. According to the use of the composition for alleviating inflammation activity of lung cells, the composition comprises a compound selected from a group consisting of ursolic acid, vanillin, kaempferol-3-glucose, benzoic acid, rosmarinic acid, dihydrodehydrodiconiferyl alcohol, 6-hydroxythymol 3-O-beta-D-glucopyranoside, caffeic acid, 4,5-di-O-(4-hydroxy-3,5-methoxy-benzoyl)-shikimic acid, glyceryl monocaffeate, or any combination thereof, and a pharmaceutically acceptable carrier.

Description

technical field [0001] The present invention relates to the new use of the composition, especially the use of a compound and its composition for preparing medicines for alleviating the inflammation activity of lung cells. Background technique [0002] The lungs are both breathing organs and filtering organs. The lungs usually secrete mucus to form a protective layer to prevent pathogens (such as viruses, bacteria, fungi) or aerosols in the inhaled air from adsorbing to the lungs. However, the ability of the lung to remove foreign matter is limited, and some foreign matter may penetrate this protective layer and infect or damage the lungs, causing lung inflammation. In addition, pulmonary contusion, sepsis, hemorrhagic shock, etc. can cause severe lung inflammation. A variety of immune cells (such as macrophages, neutrophils) involved in the inflammatory response and the stimulated secretion of pro-inflammatory cytokines (such as interleukin, tumor necrosis factor-α (TNF-α)...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K31/11A61K31/7048A61K31/192A61K31/216A61K31/343A61K31/7034A61K31/235A61P29/00A61P11/00
CPCA61K31/56A61K31/11A61K31/7048A61K31/192A61K31/216A61K31/343A61K31/7034A61K31/235A61P29/00A61P11/00A61K2300/00
Inventor 林咏翔
Owner 百岳特生物科技(上海)有限公司
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