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Hair loss prevention and hair growth purpose of gentiopicroside

A kind of gentiopicroside, hair loss technology, applied in hair growth preparations, gentiopicroside can solve problems such as contact dermatitis in the field of anti-hair loss preparation

Inactive Publication Date: 2020-12-04
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above two drugs need to be used twice a day for a long time to maintain the effect, and there are common side effects such as contact dermatitis

Method used

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  • Hair loss prevention and hair growth purpose of gentiopicroside
  • Hair loss prevention and hair growth purpose of gentiopicroside
  • Hair loss prevention and hair growth purpose of gentiopicroside

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: The curative effect evaluation experiment of gentiopicroside of the present invention on the natural hair growth model of C57BL / 6 mice

[0042] 1. Design of animal experiments

[0043]SPF-grade male C57BL / 6 mice, 7 weeks old, weighing 18-20g, were purchased from Yangzhou University and adaptively bred in an SPF-grade animal room for one week. One week later, the mice were weighed, and 4% chloral hydrate was injected intraperitoneally at a dose of 10ml / kg. After the anesthesia of the mice was completed, all the back hair of the mice was carefully shaved with an electric shaver, and the cut size was 5.2cm×2.6cm. After tearing off the wax paper, stick it on the center of the back of the mouse along the hair growth direction of the mouse, fix the tail of the mouse, quickly tear the wax paper against the hair growth direction, and then wipe it with a moisturizing paper to remove all the telogen hairs and induce height Synchronized anagen hair follicle development...

Embodiment 2

[0060] Example 2: The curative effect evaluation experiment of gentiopicroside of the present invention on C57BL / 6 mouse chemotherapy alopecia model

[0061] 1. Animal experiment design

[0062] SPF-grade male C57BL / 6 mice, 7 weeks old, weighing 18-20g, were purchased from Yangzhou University and adaptively bred in an SPF-grade animal room for one week. One week later, the mice were weighed, and 4% chloral hydrate was injected intraperitoneally at a dose of 10ml / kg. After the anesthesia of the mice was completed, all the back hair of the mice was carefully shaved with an electric shaver, and the cut size was 5.2cm×2.6cm. After tearing off the wax paper, stick it on the center of the back of the mouse along the hair growth direction of the mouse, fix the tail of the mouse, quickly tear the wax paper against the hair growth direction, and then wipe it with a moisturizing paper to remove all the telogen hairs and induce height Synchronized anagen hair follicle development.

[0...

Embodiment 3

[0073] Example 3: The curative effect evaluation experiment of gentiopicroside of the present invention on the androgenetic alopecia model of C57BL / 6 mice

[0074] 1. Animal experiment design

[0075] SPF-grade male C57BL / 6 mice, 7 weeks old, weighing 18-20g, were purchased from Yangzhou University and adaptively bred in an SPF-grade animal room for one week. Testosterone propionate was used to establish an animal model of androgenetic alopecia. The commercially available testosterone propionate concentration was 25 mg / ml, and the injection and olive oil were diluted 1:24 to prepare a 1 mg / ml testosterone propionate dilute solution, and 100 μl of 1mg / ml dilute solution of testosterone propionate was injected subcutaneously into the back of C57 mice once a day for 4 weeks. After 2 weeks of modeling, the hair lost its luster. With the prolongation of the injection time of testosterone propionate, the hair began to become sparse, and the back There was a lot of oil overflowing f...

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PUM

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Abstract

The invention provides gentiopicroside, a purpose of the physically acceptable salt or solvate of the gentiopicroside for preparing a skin application composition, and further application of the skinapplication composition in medicinal preparations, cosmetics, nursing products and beautifying products. The skin application composition and the further applied preparation can comprehensively and effectively aim at various hair loss reasons so as to be more favorable for balancing a metabolism situation of a demand object, regulating the mental state of the demand object to achieve a better treatment and nursing synergistic effect, in addition, the gentiopicroside has high active ingredient safety and a small toxic and side effect, and therefore, the gentiopicroside has a wide application prospect in fields, including medicinal preparations, cosmetics, nursing products, beautifying products and the like.

Description

technical field [0001] The invention belongs to the field of compounds and preparations thereof, and specifically relates to the use of gentiopicroside in the preparation of anti-hair loss and hair growth preparations, and its further application in the fields of medicine, cosmetics, nursing products, beauty products and the like. Background technique [0002] Hair loss is caused by a variety of factors, including hormones, chemotherapy, and nutritional deficiencies, and while hair loss is not life-threatening, its profound impact on social interactions and the patient's mental health is undeniable, so hair loss is about appearance for contemporary people a serious problem. Hair transplants and growth factor injections are available to treat hair loss, but so far, only two drugs, minoxidil and finasteride, have been approved by the US FDA to treat hair loss. Minoxidil is an arterial dilator that was originally developed as a treatment for high blood pressure but found use i...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P17/00A61P17/14A61P17/08A61P17/10A61K8/60A61Q7/00A61Q5/00
CPCA61K8/602A61K31/7048A61Q5/002A61Q7/00A61P17/00A61P17/08A61P17/10A61P17/14
Inventor 吴亮冯陈杰蔡磊蔡溪云弋吴舒婷董昊郝园园陈佳敏刘宙刘玉琳朱俊霖徐佳怡曹毅眀吴晓明
Owner CHINA PHARM UNIV
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