Organ preservation device with adjustable solution oxidation-reduction potential and implementation method thereof

A technology for organ preservation and solution, which is applied in the field of organ preservation devices with adjustable oxidation-reduction potential of the solution, which can solve the problems of poor preservation or perfusion effect and poor control of isolated organs, and achieve the goal of ensuring stability and improving ion exchange Speed, the effect of improving the survival rate

Active Publication Date: 2020-12-18
WEST CHINA HOSPITAL SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the aerobic preservation devices for isolated organs currently used by us do not control the oxygen concentration well during preservation or perfusion, resulting in poor preservation or perfusion effects of isolated organs

Method used

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  • Organ preservation device with adjustable solution oxidation-reduction potential and implementation method thereof
  • Organ preservation device with adjustable solution oxidation-reduction potential and implementation method thereof
  • Organ preservation device with adjustable solution oxidation-reduction potential and implementation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Such as Figure 1-9 As shown, an organ preservation device with adjustable oxidation-reduction potential of the present invention includes a control box 22 , a liquid storage tank 1 , and a PID controller 23 . Among them, the liquid storage tank 1 is composed of an organ storage chamber, an anode chamber and a cathode chamber. In order to realize the adjustment of the temperature, pH value, PO2 and ORP of the organ preservation solution, the And the storage solution index intervention system is respectively set in the cathode chamber. Such as figure 1 As shown, the preservation fluid index intervention mechanism includes an oxygen flow rate controller 24, a semiconductor heater 25, a semiconductor refrigerator 26, and a magnetic stirrer 3 respectively arranged in the control box 22, and respectively arranged in the organ holding chamber, Oxygen supplement pipe 27, semiconductor heating sheet 28, semiconductor cooling sheet 29, magnetic rotor 4 at the bottom of the ano...

Embodiment 2

[0070] Such as Figure 10 As shown, this embodiment is the implementation method of the organ preservation device with adjustable redox potential of the solution in embodiment 1, which includes the following steps:

[0071] Step 1: Establish a database of various indicators of preservation solutions required for different organ preservation.

[0072] Specifically, the steps for establishing various index databases of preservation solutions required for different organ preservation are as follows:

[0073] 1) Set multiple sets of ORP and temperature values ​​required for different preservation organs; among them, according to the environmental temperature difference that occurs in different seasons, set four sets of ORP and temperature values ​​for the preservation solution of each organ.

[0074] 2) Collect the pH value and PO2 of the initial state of the preservation solution in each chamber, and the initial components and concentration values ​​of the preservation solution ...

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Abstract

The invention discloses an organ preservation device with adjustable solution redox potential, which is characterized by comprising a control box (22), a liquid storage box (1) and a PID controller (23). The invention further discloses an implementation method of the organ preservation device with the adjustable solution oxidation-reduction potential. The implementation method comprises the following steps: establishing various index databases of preservation solutions required by different organ preservation; and after the organ to be stored is put into the storage liquid, extracting variousindex data of the storage liquid of the organ to be stored from various index databases of the storage liquid, and sending the index data to a PID controller (23) for storage. According to the invention, the harmful components generated by continuous metabolism in the organ preservation process can be effectively eliminated, and the stability of macromolecules with the oxygen carrying function inthe preservation liquid in the organ containing cavity is ensured; meanwhile, through the arranged detection mechanism, real-time monitoring of the temperature, the pH value, the PO2 and the ORP of the solution of the preserving fluid in each chamber can be achieved.

Description

technical field [0001] The invention relates to the field of organ preservation, and specifically provides an organ preservation device with adjustable oxidation-reduction potential of a solution and a realization method thereof. Background technique [0002] Oxidation reduction potential (ORP) is a quantitative indicator that expresses the oxidation or reduction ability of a redox system in chemical science. ORP, which is commonly referred to in the world, is expressed in the form of reduction potential, which specifically refers to a physical quantity that is difficult for a substance to obtain electrons from an oxidized state to a reduced state, and is measured with the standard that the potential of the standard hydrogen electrode is zero. There are also a variety of substances that affect ORP in biological systems, such as reactive oxygen species (reactive oxygen species, ROS) in plasma contribute to the generation of oxidation potential, while reducing agents in plasma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
CPCA01N1/0242
Inventor 李建波
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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