Detection antibody of anti-VEGFR-2 monoclonal antibody, application and detection method

A VEGFR-2, monoclonal antibody technology, applied in the field of bioengineering, can solve problems such as inconvenience of antibodies
CN112094351AActive Publication Date: 2020-12-18BEIJING DONGFANG BIOTECH +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING DONGFANG BIOTECH
Publication Date
2020-12-18

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Abstract

The invention provides a detection antibody of an anti-VEGFR-2 monoclonal antibody, application and a detection method. The detection antibody comprises a heavy chain variable region and a light chainvariable region, and the amino acid sequence of the heavy chain variable region is selected from SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7 or SEQ ID NO: 8; and the amino acid sequence of the light chain variable region is selected from SEQ ID NO: 9, SEQ ID NO: 10, SEQ ID NO: 11 or SEQ ID NO: 12. According to the detection antibody, the detection antibody aiming at the anti-VEGFR-2 monoclonal antibody is obtained by screening, the antibody can be used for rapidly, sensitively and accurately detecting the drug concentration of the anti-VEGFR-2 monoclonal antibody in body fluid, and a reliable research method is provided for assisting the clinical diagnosis of the anti-VEGFR-2 monoclonal antibody and the pharmacological and pharmacokinetic analysis of a clinical test.
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Description

technical field

[0001] The invention relates to the technical field of bioengineering, in particular to a detection antibody, application and detection method of an anti-VEGFR-2 monoclonal antibody. Background technique

[0002] The dependence of tumor growth on the formation of new blood vessels has been thoroughly studied in tumor biology. Neoangiogenesis refers to the process of budding new blood vessels from pre-existing capillaries. This process is stimulated and regulated by a variety of factors, including basic fibroblast growth factor (BFGF), vascular endothelial growth factor (vascular endothelial growth factor, VEGF), platelet-derived growth factor (platelet -derived growth factor, PDGF), angiopoietin-1 (angiopoietin-1), hepatocyte growth factor (hepatocyte growth factor, HGF), transforming growth factor-β (transforming growth factor-β, TGF-β), interleukin Prime 6 (interleukin-6, IL-6) and so on. Among them, VEGF is the most powerful and specific factor to stimu...

Claims

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