Safe and non-toxic nerve cell restoring drug

A nerve cell, safe and non-toxic technology, applied in the field of nerve cell repair drugs, can solve problems such as increased absorption and reduced drug dosage, and achieves high cure rate, guaranteed barrier breaking rate, and good drug effect.

Pending Publication Date: 2020-12-29
SHENZHEN PKU HKUST MEDICAL CENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nanoformulation technology is considered to be one of the feasible approaches for cross-BBB drugs, but the main disadvantage of nanoformulations is that they will be rapidly eliminated in the internal circulation, which is mainly attributed to the increased absorption of nanoformulated drugs by all organs in the body, thus reducing amount of drug reaching the brain

Method used

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  • Safe and non-toxic nerve cell restoring drug
  • Safe and non-toxic nerve cell restoring drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] see figure 1 , in the safe and non-toxic nerve cell repair medicine disclosed in the preferred embodiment 1 of the present application, ginsenoside Rb3 is used as the main component, and the main component of ginsenoside Rb3 contains 55.8 parts of coarse-grained Rb3 particles and 5.2 parts of medium-sized Rb3 particles , 39 parts of fine-grained Rb3 particles. Among them: the particle size of coarse-grained Rb3 particles is not less than 100nm, the particle size of medium-sized Rb3 particles is between 10nm and 100nm, and the particle size of fine-grained Rb3 particles is not more than 10nm. In addition, the particle diameters of the coarse-grained Rb3 particles are concentrated at 436 nm, and the particle diameters of the fine-grained Rb3 particles are concentrated at 6 nm.

Embodiment 2

[0024] In the safe and non-toxic nerve cell repair drug disclosed in the preferred embodiment 2 of the present application, ginsenoside Rb3 is used as the main component, and the main component of ginsenoside Rb3 contains 58 parts of coarse-grained Rb3 particles and 5.5 parts of medium-sized Rb3 particles. 40 parts of fine-grained Rb3 particles. Among them: the particle size of coarse-grained Rb3 particles is not less than 100nm, the particle size of medium-sized Rb3 particles is between 10nm and 100nm, and the particle size of fine-grained Rb3 particles is not more than 10nm. In addition, the particle diameters of the coarse-grained Rb3 particles are concentrated at 436 nm, and the particle diameters of the fine-grained Rb3 particles are concentrated at 6 nm.

Embodiment 3

[0026] In the safe and non-toxic nerve cell repair drug disclosed in Preferred Example 3 of the present application, ginsenoside Rb3 is used as the main component, and the main component of ginsenoside Rb3 contains 55 parts of coarse-grained Rb3 particles and 5 parts of medium-sized Rb3 particles. 38 parts of fine-grained Rb3 particles. Among them: the particle size of coarse-grained Rb3 particles is not less than 100nm, the particle size of medium-sized Rb3 particles is between 10nm and 100nm, and the particle size of fine-grained Rb3 particles is not more than 10nm. In addition, the particle diameters of the coarse-grained Rb3 particles are concentrated at 436 nm, and the particle diameters of the fine-grained Rb3 particles are concentrated at 6 nm.

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Abstract

The invention belongs to the technical field of drugs and particularly relates to a safe and non-toxic nerve cell restoring drug. The safe and non-toxic nerve cell restoring drug comprises a ginsenoside Rb3 main ingredient and is characterized in that the ginsenoside Rb3 main ingredient comprises the ingredients in parts by mass: 55-58 parts of big-particle-size Rb3 particles, wherein the particlesize of the big-particle-size Rb3 particles is not smaller than 100nm; 5-5.5 parts of medium-particle-size Rb3 particles, wherein the particle size of the medium-particle-size Rb3 particles is 10nm to 100nm; and 38-40 parts of small-particle-size Rb3 particles, wherein the particle size of the small-particle-size Rb3 particles does not exceed 10nm. According to the safe and non-toxic nerve cell restoring drug, through reasonable particle size distribution, when the safe and non-toxic nerve cell restoring drug is used for treating cerebrovascular diseases, particularly Parkinson's disease in amanner of assisting ultrasonic medical equipment, a good barrier breaking rate can be guaranteed, and an effective amount of drug entering brain cells can be guaranteed; and compared with the prior art, the safe and non-toxic nerve cell restoring drug has the technical effects of safety, no toxicity, good medication effect, high cure rate and the like.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a safe and nontoxic medicine for repairing nerve cells. Background technique [0002] Parkinson's disease (PD) is a common chronic central neurodegenerative disease characterized by the degeneration of the nigrostriatal pathway, and the degeneration of heterogeneous nerve cells (mainly dopaminergic neurons) Its neuropathological features can involve different neurotransmitter systems and different nervous system regions. One of the conditions that must be met for nerve repair: whether it can pass through the blood brain barrier (BBB). The blood-brain barrier is a general term for the three barriers of blood and brain tissue, blood and cerebrospinal fluid, and cerebrospinal fluid and brain tissue. Among them, the first two have an important selective effect on the drug penetration, because the brain capillary endothelial cells are indirectly dense, the gap is small...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/704A61P25/16A61P9/10A61P25/00
CPCA61K9/14A61K31/704A61P25/16A61P9/10A61P25/00
Inventor 陈芸郑婷婷张柱霞吕桃王梦欣成官迅戚玉龙
Owner SHENZHEN PKU HKUST MEDICAL CENT
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