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Method for stratifying ibs patients

A patient-algorithmic technology applied to patient-specific data, neural learning methods, data from laboratory analysis, etc.

Pending Publication Date: 2021-01-15
4D PHARMA
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Conventional computer-implemented methods and systems fail to reliably and

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  • Method for stratifying ibs patients
  • Method for stratifying ibs patients
  • Method for stratifying ibs patients

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Embodiment Construction

[0075] Described herein are methods and systems that enable accurate stratification of IBS patients from their microbiomes, particularly where the patient's microbiome is similar to the average microbiome of a person without IBS. Previously, it was a challenge to distinguish this specific subgroup of IBS patients from those with altered microbiomes.

[0076] Furthermore, diagnosing IBS from a patient's microbiome can lead to a more informed diagnosis than from patient-reported symptoms alone, where the latter can lead to variable and inaccurate results and inappropriate treatment strategies. Therefore, it would be advantageous to be able to diagnose a patient's IBS from the patient's microbiome. Additionally, methods and systems are described herein that can be used to generate a trained classifier for performing IBS diagnoses. A trained classifier can be stored for execution by the processor using the microbiome data of the test sample to provide an output indicative of the ...

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Abstract

A computer-implemented method for stratifying a patient with irritable bowel syndrome (IBS). The method comprises detecting the presence,absence, or abundance of multiple bacteria in a biological sample obtained from the patient to generate a patient microbiome profile; and operating a trained classifier on the patient microbiome profile to output a signal stratifyingthe patient with irritable bowel syndrome (IBS) into a first group or a second group. Stratification of the patient into the first group is indicative that the patient has a not significantly altered microbiome in comparison to the averagemicrobiome not indicative of IBS. Stratification of the patient into the second group is indicative that the patient has an altered microbiome in comparison to the averagemicrobiome not indicative of IBS. Figure4to be published with the abstract.

Description

technical field [0001] The present disclosure relates to systems and methods for stratifying irritable bowel syndrome (IBS) patients and systems and methods for generating a trained classifier for stratifying IBS patients. Background technique [0002] IBS is a lifelong gastrointestinal disorder that usually begins in adolescence or early adulthood and is poorly understood. Effective treatments for IBS represent an unmet need. Available treatments are remedies of limited efficacy, often targeting specific symptoms rather than cures, and drug trials have long failed. Furthermore, there is low tolerance for modulation of the toxicity of salvage approaches in IBS, and there is growing interest in safe non-traditional pharmaceutical strategies, such as manipulation of the microbiome with live biotherapeutics (LBTs). [0003] Irritable bowel syndrome (IBS) is a debilitating chronic functional gastrointestinal disorder with an estimated population prevalence of between 10% and 1...

Claims

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Application Information

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IPC IPC(8): G16H50/70
CPCG16H50/70Y02A90/10G16H50/20G16H10/60G16H70/60G16C20/70G16C20/40G06N20/00G06N3/08A61B2018/00494G16H10/40G06N20/20G16B40/00G06N5/01
Inventor 弗格斯·沙纳汉保罗·W·奥图尔伊恩·B·杰弗里
Owner 4D PHARMA
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